Antitumor mechanisms of bifidobacteria (Review)

Wei, Haixia; Chen, Lin Lin; Lian, Guanghui; Yang, Junwen; Li, Fujun; Zou, Yiyou; Lu, Fanggen; Yin, Yani

doi:10.3892/ol.2018.8692

Cited by 28 publications

(29 citation statements)

References 80 publications

(74 reference statements)

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“…Lactic acid producing bacteria (LAB) have been shown to confer protection against CRC [22]. Bifidobacterium, a LAB and part of normal human microflora, has been reported to have anti-tumor properties [23]. In a human study, it was found that intake of yogurt containing Bifidobacterium longum resulted in increased amounts of short-chain fatty acids (SCFAs) and decreased Bacteroides fragilis enterotoxin in feces.…”

Section: Bacteria and Protection Against Colorectal Cancermentioning

confidence: 99%

“…B. longum administration increased expression of tumor suppressor micro-RNAs (miRs) miR-145 and miR-155, decreased expression of miR-146a (regulator of interleukins 1β and 6), decreased nuclear factor kappa-light-chain-enhancer of activated B cell (NF-κB) activation and resulted in decreased aberrant crypt foci numbers[23] Dietary supplementation with B. longum led to 100% inhibition of IQ-induced incidence of CRC[24] Ingesting B. longum with FOS leads to decreased B. fragilis enterotoxin, increased production of SCFAs, and subsequent inhibition of colorectal carcinogenesis and cancer cell growth[22] Decreased expression of oncogenic miRNAs and increased expression of tumor suppressor miRNAs[23] Lactobacillus Rat model of 1,2-dimethylhydrazine (DMH)-induced precancerous growths in colon[53] Murine model of azoxymethane (AOM)-induced colon cancer[54] Rat model of 1, 2-dimethylhydrazine (DMH)-induced CRC[55] Rat model of 1,2-dimethyl hydrazine (DMH)-induced CRC[56] …”

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confidence: 99%

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Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

Lamichhane

Maiolini

Alnafoosi

et al. 2020

Cancers

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Colorectal cancer (CRC) is one of the most common types of cancer worldwide. There are many factors that predispose a patient to the disease such as age, family history, ethnicity, and lifestyle. There are different genetic factors and diseases that also increase a person’s risk for developing CRC. Studies have found associations between gut microbiome and the risk for developing versus protection against CRC. Normal gut microbiome aid in daily functions of the human body such as absorption, metabolism, detoxification, and regulation of inflammation. While some species of bacteria prevent CRC development and aid in therapeutic responses to various treatment regiments, other species seem to promote CRC pathogenesis. In this regard, many studies have been conducted to not only understand the biology behind these opposing different bacterial species; but also to determine if supplementation of these tumor opposing bacterial species as probiotics lends toward decreased risk of CRC development and improved therapeutic responses in patients with CRC. In this literature review, we aim to discuss the basics on colorectal cancer (epidemiology, risk factors, targets, treatments), discuss associations between different bacterial strains and CRC, and discuss probiotics and their roles in CRC prevention and treatment.

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Section: Bacteria and Protection Against Colorectal Cancermentioning

confidence: 99%

mentioning

confidence: 99%

Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

Lamichhane

Maiolini

Alnafoosi

et al. 2020

Cancers

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“…Our results revealed that the effects of probiotics are different in comparison to each other and based on tumor cell type. Several studies have approved the antitumor effect of Lactobacillus acidophilus and Bifidobacterium bifidum [17,18]. This experiment demonstrated that the mixture of Lactobacillus acidophilus and Bifidobacterium bifidum have a boosting effect in tumor inhibition of the MCF7 cell line.…”

Section: Discussionmentioning

confidence: 87%

The Probiotic Bacteria Induce Apoptosis in Breast and Colon Cancer Cells: An Immunostimulatory Effect

2020

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Background: Uncontrolled cell proliferation and resistance to apoptosis are the main characteristics of cancer cells. Therefore, a substance with the capability to induce apoptosis in cancer cells could be known as an anti-cancer material. Probiotics are useful microorganisms that are crucial for the host's health. Materials and Methods: In the present study, we evaluated the synergic effect of probiotic bacteria on the cytotoxic potency of cancer cells and apoptosis genes expression. Lactobacillus acidophilus and Bifidobacterium bifidum were cultured in MRS broth and then MTT test was performed on AGS, MCF-7, and peripheral mononuclear cells after treatment with the bacterial corpse. β-actin, Bcl2, Bax, TNF-α, and IFN-γ gene expression were evaluated in treated cell lines by real-time PCR method. Results: The result of cytotoxicity assay showed that bacterial corpse has higher cytotoxicity effects on cancer cells compared with normal cells. Results of gene expression demonstrated that Bcl2 and Bax gene expression significantly increased in cancer cells and TNF-α gene expression remarkably increased in normal cells as compared with the control group. Conclusion: Probiotic bacterial corpse can induce apoptosis in cancer cells. In normal cells, the immune system shifts responses toward Th1 and inflammatory cytokines.

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“…Our results revealed that the effect of the probiotics is different in comparison to each other based on tumor cell type. Several studies have approved the antitumor effect of LB [19,20].…”

Section: Figure 2 Gene Expression Assaymentioning

confidence: 99%

Lactobacillus Acidophilus Cytotoxicity Effect and Apoptosis in Human Bladder Carcinoma Cells: An In Vitro Study

Taheri

Moazamian

Mahdavi

2021

Immuno

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Introduction: Anticancer effects of Lactobacillus acidophilus, as a probiotic bacterium, have been indicated in several studies. There are common therapeutic options for bladder cancer treatment; however, their side effects and recurrence of disease are considerable. Therefore, complementary medication is essential and it must be safe and effective. In the present research, we assessed the anti-tumor activity of Lactobacillus acidophilus (LB) on the bladder cancer cell line by evaluating the apoptosis mechanism. Materials and Methods: EJ138 bladder cancer cell line was provided and the cytotoxicity level of LB was evaluated with various concentrations after 24, 48, and 72 h. To evaluate the apoptosis effect, the gene expression of Bax, BCL2, and TNF-α was assessed using real-time PCR. Results: The optimum concentration of the cytotoxicity level was 12.5μg/mL at 24, 48, and 72 h. Bax expression was upregulated in tumor cells treated with LB alone and the mixture of LB and BCG (LB/BCG) as compared to the control group after 24 and 48 h. Also, the mRNA level of TNF-α increased in treated cells with LB and LB/BCG compared to the control group. BCL2 expression did not show a significant difference between experimental groups versus the control group. Conclusion: Our findings showed that LB has a synergistic effect with BCG through increasing apoptotic gene expression and TNF-α cytokine. Besides, at 48 h treatment, the apoptosis effect is more than 24 h. Thus, it seems that the mode of action of LB is time-dependent.

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Antitumor mechanisms of bifidobacteria (Review)

Cited by 28 publications

References 80 publications

Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

Colorectal Cancer and Probiotics: Are Bugs Really Drugs?

The Probiotic Bacteria Induce Apoptosis in Breast and Colon Cancer Cells: An Immunostimulatory Effect

Lactobacillus Acidophilus Cytotoxicity Effect and Apoptosis in Human Bladder Carcinoma Cells: An In Vitro Study

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