Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells

Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways

“…Piperine may also may inhibit the activation of Shc, which lies upstream of ERK1/2 and Akt in IL-2R signaling (Gu et al, 2000;Ravichandran and Burakoff, 1994). Inhibition of ERK1/2 phosphorylation by piperine has been reported in breast cancer cells (Do et al, 2013), fibrosarcoma cells (Hwang et al, 2011), and fibroblast-like synoviocytes (Bang et al, 2009); however, piperine increases basal ERK1/2 phosphorylation in immortalized auditory cells (Choi et al, 2007). The effect of piperine on ERK1/2 phosphorylation can, therefore, differ depending on cell type and activating signals.…”

Combined effect of paclitaxel and piperine on a MCF-7 breast cancer cell line in vitro: Evidence of a synergistic interaction

“…Paclitaxel may have different mechanism of cell apoptosis but earlier studies demonstrated reduced cytotoxicity in HER2 (human epidermal growth factor receptor 2) overexpressing breast cancer cells [38]. Recent studies demonstrated that piperine inhibited the growth of breast cancer cell lines in triple negative breast cancer [39], as well as those with estrogen receptorpositive breast cancer, via an antiproliferative effect and induction of caspase-dependent apoptosis [40]. Based on the above data and results, we hypothize that the mechanism of synergy interaction of the combinations of piperine and paclitaxel may involve an EGFR (epidermal growth factor receptor) signaling blockade.…”

Enhancing Activity of Anticancer Drugs in Multidrug Resistant Tumors by Modulating P-Glycoprotein through Dietary Nutraceuticals

“…Piperine is the major plant alkaloids present in black pepper (Piper nigrum Linn) (Han et al, 2008;Do et al, 2013;Singh et al, 2013) and long pepper (Piper longum Linn) (Bezerra et al, 2008). Black pepper is one of the most common spice consumed by a large number of populations worldwide.…”