Antitumor effect of Ferula assa foetida oleo gum resin against breast cancer induced by 4T1 cells in BALB/c mice

Abstract

BackgroundFerula assa foetida commonly consumed as a healthy beverage has been demonstrated to have various biological activities, including antioxidation, anti-obesity and anti-cancer.ObjectiveOur study aims to investigate the antitumor effect of asafoetida in vivo using mouse mammary carcinoma 4T1 cells.Materials and methodsIn the study, female BALB/c mice were divided into two groups (n = 6), which were control (untreated) and other group of mice with breast cancer treated with 100 mg/kg of asafoetida, respectively, by oral gavage. All mice were injected into the mammary fat pad with 4T1 cells (1 × 105 4T1 cells/0.1 ml of phosphate buffer solution). Asafoetida was administered on day 15 after the tumor had developed for 3 weeks. At end of experiment, tumor weight, tumor volume and tumor burden were measured and lung, liver, kidney and tumor were harvested and sections were prepared for histopathological analysis. Lipoxygenase inhibitory and antioxidant activity of asafoetida was also determined.ResultsOur results showed that treatment with asafoetida was effective in decreasing the tumor weight and tumor volume in treated mice. Body weight significantly increased in female BALB/c mice against control. Apart from the antitumor effect, asafoetida decreased lung, liver and kidney metastasis and also increased areas of necrosis in the tumor tissue respectively.ConclusionsThe present study demonstrated that asafoetida has potent antitumor and antimetastasis effects on breast cancer and is a potential source of natural antitumor products.

Antibacterial and Cytotoxic Potential of Biosynthesized Silver Nanoparticles by Some Plant Extracts

“…The silver nanoparticles showed good anticancer activity against LoVo cells line with IC50 values lower than that as reported by [ 57 ], and they reported against HCT-116 Colon Cancer Cells when Commelina nudiflora L. Aqueous Extract was used for the biogenic synthesis of AgNPs [ 58 ]. The antitumor ability of asafoetida on breast cancer is well-documented [ 59 ]. Current investigations show significant antiproliferative action of biosynthesized AgNPs by alcoholic plant extract against LoVo cell lines that may lead to growth cell suppression.…”

COVID-19, cytokines, inflammation, and spices: How are they related?

“…It modulates the NF-κB and transforming growth factor (TGF)-β pathway by downregulating the expression of NF-κB1 and TGF-β1. Furthermore, it enhances the production of caspase-3 and TNF-α [ 221 ] Asafetida exhibits potent antitumor effects against breast cancer in BALB/c nude mice [ 222 ] It also enhances the activities of antioxidant enzymes such as catalase, glutathione (GSH), glutathione-s-transferase (GST), superoxide dismutase (SOD), in an N -methyl-N-nitrosourea (MNU)-induced breast cancer in Sprague-Dawley rats [ 223 ]. The activity of LOX is reportedly decreased by asafoetida [ 222 , 224 ].…”

Ameliorative Effect of the Oral Administration of Chuquiraga spinosa in a Murine Model of Breast Cancer Induced with 7,12-Dimethylbenz[a]anthracene (DMBA)

“…In Peru, this cancer represents the second most frequent neoplasm, affects the adult woman and is an important cause of disease burden. 1,2 It has genetic, environmental, and lifestyle factors interacting to cause this disease. 3 Breast cancer is treated by surgery, chemotherapy, radiotherapy, alone or combined depending on the severity.…”