Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae)

Kuete, Victor; Mbaveng, Armelle T.; Tsaffack, Maurice; Beng, Véronique Penlap; Etoa, François–Xavier; Nkengfack, Augustin E.; Meyer, J.J.M.; Lall, Namrita

doi:10.1016/j.jep.2007.10.027

Cited by 78 publications

(65 citation statements)

References 24 publications

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“…The antimicrobial potency of Stipulin as well as that of many natural occurring chalcones, flavones and coumarins is well documented ( [Cowan, 1999], [Kuete et al, 2007a], [Kuete et al, 2007b] and [Kuete et al, 2008]). In this study, the antibacterial and antifungal activities of the crude extract and compounds 1, 3, 4 and 5 were evaluated and the results are reported in Table 1 and Table 2.…”

Section: Resultsmentioning

confidence: 99%

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Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

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148

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The aim of this study was to evaluate the antimicrobial activity of the crude extract of the twigs of Dorstenia barteri (DBT) as well as that of four of the five flavonoids isolated from this extract. Gram-positive bacteria (six species), Gram-negative bacteria (12 species) and fungi (four species) were used. The agar disc diffusion test was used to determine the sensitivity of the tested samples while the well micro-dilution was used to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentration (MMC) of the active samples. The results of the disc diffusion assay openUP (May 2008) showed that DBT, isobavachalcone (1), and kanzonol C (4) prevented the growth of all the 22 tested microbial species. Other compounds showed selective activity. The inhibitory activity of the most active compounds namely compounds 1 and 4 was noted on 86.4% of the tested microorganisms and that of 4-hydroxylonchocarpin (3) Abbreviations

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Section: Resultsmentioning

confidence: 99%

“…Nutrient agar (NA) (Oxoid) containing bromocresol purple was used for the activation of Bacillus species ( [Marchal et al, 1985] and [Kuete et al, 2008]), while NA was used for other bacteria. Sabouraud glucose agar (Oxoid) was used for the activation of the fungi.…”

Section: Culture Media and Microbial Identificationmentioning

confidence: 99%

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Mbaveng

Ngameni

Kuete

et al. 2008

Journal of Ethnopharmacology

Self Cite

148

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“…All strains were precultured overnight on Mueller-Hinton agar, prior to any assay. Mueller-Hinton broth (MHB) was used as the liquid culture medium for susceptibility tests (13,20).…”

Section: Methodsmentioning

confidence: 99%

“…The MICs of the two compounds and antibiotics were determined by a rapid INT colorimetric assay (8,13). Briefly, the test sample and selected antibiotics were first dissolved in dimethyl sulfoxide (DMSO)-MHB.…”

Section: Methodsmentioning

confidence: 99%

Efflux Pumps Are Involved in the Defense of Gram-Negative Bacteria against the Natural Products Isobavachalcone and Diospyrone

Kuete

Ngameni

Tangmouo

et al. 2010

Antimicrob Agents Chemother

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101

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The activities of two naturally occurring compounds, isobavachalcone and diospyrone, against documented strains and multidrug-resistant (MDR) Gram-negative bacterial isolates were evaluated. The results indicated that the two compounds exhibited intrinsic antibacterial activity against several Gram-negative bacteria, and their activities were significantly improved in the presence of an efflux pump inhibitor (MIC values decreased to below 10 g/ml). In addition, the activities of isobavachalcone and diospyrone against various strains exhibiting deletions of the major efflux pump components (AcrAB, TolC) were significantly increased. The overall results indicate that isobavachalcone and diospyrone could be candidates for the development of new drugs against MDR strains and that their use in combination with efflux pump inhibitors reinforces their activity.

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“…After 24 hours of incubation at 37°C, the test tubes were observed for turbidity changes. The least concentration which showed no visible growth (turbidity) was denoted as the MIC value for the particular extracts (Kuete et al, 2008 andSahgal et al, 2009). …”

Section: Determination Of Minimum Inhibitory Concentration (Mic) Valuementioning

confidence: 99%

Anti-candida activity by <i>Hymenocallis littoralis</i> extracts for opportunistic oral and genital infection <i>Candida albicans</i>

Sundarasekar

Sahgal

Subramaniam

2012

Bangladesh J Pharmacol

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Antitumor, antioxidant and antimicrobial activities of Bersama engleriana (Melianthaceae)

Cited by 78 publications

References 24 publications

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae)

Efflux Pumps Are Involved in the Defense of Gram-Negative Bacteria against the Natural Products Isobavachalcone and Diospyrone

Anti-candida activity by <i>Hymenocallis littoralis</i> extracts for opportunistic oral and genital infection <i>Candida albicans</i>

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