Antitumor and immunomodulatory effects of salvigenin on tumor bearing mice

Noori, Shokoofe; Hassan, Zuhair Mohammad; Yaghmaei, Bahram; Dolatkhah, Milad

doi:10.1016/j.cellimm.2013.10.005

Cited by 26 publications

(21 citation statements)

References 20 publications

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“…On the other hand, salvigenin is the major active constituent of T. fontanesii. It has a wide range of biological effects, including antioxidant, antitumor, antibacterial and vasorelaxant activities in isolated rat aortas, immunomodulatory activities, inhibition of the growth of malarial parasites, and potent antiinflammatory effects [18,19] The anti-inflammatory effect of T. algeriensis may be related to its major active constituents, rosmarinic acid and rosmarinic glucoside. Previous studies showed that rosmarinic acid has potent anti-inflammatory effect through inhibition of NF-κB activation [17].…”

Section: Effects Of T Algeriensis and T Fontanesii Extracts On Carrmentioning

confidence: 99%

Section: Effects Of T Algeriensis and T Fontanesii Extracts On Carrmentioning

confidence: 99%

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Thymus algeriensis and Thymus fontanesii: Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison

et al. 2020

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This study aimed to investigate the chemical composition, and evaluate the antioxidant, anti-inflammatory, anti-pyretic, and the analgesic properties of methanol extracts from the leaves of Thymus algeriensis and Thymus fontanesii (Lamiaceae). Thirty-five secondary metabolites were characterized in both extracts using HPLC-PDA-ESI-MS/MS. Phenolic acids, mainly rosmarinic acid and its derivatives, dominated the T. algeriensis extract, while the phenolic diterpene carnosol and the methylated flavonoid salvigenin, prevailed in T. fontanesii extract. Molecular docking study was carried out to estimate the anti-inflammatory potential and the binding affinities of some individual secondary metabolites from both extracts to the main enzymes involved in the inflammation pathway. In vitro enzyme inhibitory assays and in vivo assays were used to investigate the antioxidant and anti-inflammatory activities of the extracts. Results revealed that both studied Thymus species exhibited antioxidant, anti-inflammatory, analgesic, and antipyretic effects. They showed to be a more potent antioxidant than ascorbic acid and more selective against cyclooxygenase (COX-2) than diclofenac and indomethacin. Relatively, the T. fontanesii extract was more potent as COX-2 inhibitor than T. algeriensis. In conclusion, Thymus algeriensis and Thymus fontanesii may be interesting candidates for the treatment of inflammation and oxidative stress-related disorders.

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Section: Effects Of T Algeriensis and T Fontanesii Extracts On Carrmentioning

confidence: 99%

Section: Effects Of T Algeriensis and T Fontanesii Extracts On Carrmentioning

confidence: 99%

Thymus algeriensis and Thymus fontanesii: Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison

et al. 2020

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“…However, flavonoids like diosmetin, salvigenin, naringin dihydrochalcone and vicenin-2 have been for the first time identified, and are mostly present in the hydro-alcoholic artichoke extract (see Table 3.). Diosmetin was shown by others to inhibit the metastasis of hepatocellular carcinoma cells [39,40], while salvigenin antitumor and immunomodulatory effects on tumor bearing mice had been demonstrated [41]. The naringin dihydrochalcone biological effects were not analysed to present days, however its major constituent the naringin was suggested to be the main component of Ganshuang granule that plays an anti-fibrotic role through deactivation of hepatic stellate cells in cirrhotic mouse model [42], and through the attenuation of EGFR/ERK signalling could suppress cancer cell growth [43].…”

Section: Resultsmentioning

confidence: 99%

Comparative Chemomapping of Phytoconstituents from Different Extracts of Globe Artichoke - Cynara Scolymus L.

et al. 2017

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ABSTRACT. Artichoke (Cynara scolymus L.) is a well-known herb for its efficiency in the prevention/treatment of liver injuries, among other human chronic diseases. The aim of present study was to analyse the phytoconstituents content of aqueous and hydro-alcoholic extracts obtained from the leaves of artichoke. The chemomapping was carried out using UHPLC-ESI-MS. Several new and some known phytoconstituents were identified in the two type of extracts that have slightly different composition profiles. The newly found phytoconstituents in artichoke, plead for multiple health promoting effects that have presumably more stochastic than determinative features. Therefore, further experiments are needed using such extracts, and based on a system biology approach to clarify the complexity of beneficial effects of artichoke.

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“…The correlation between the intensive phenolic content of S. eriophora (salvigenin, fumaric acid, and caffeic acid) and some of diseases treatment has been detected by many researchers. Some of them; salvigenin has affection on growth inhibition of MCF‐7 (a breast cancer cell line isolated) (Noori, Hassan, Yaghmaei, & Dolatkhah, ) causes vasorelaxation in rat aortic rings (Uydeş‐Doğan et al, ), as a neuroprotective flavone inhibits apoptosis and oxidative stress with diverse size in the cortex and hippocampus of beta‐amyloid‐injected rats (Esfandabadi, Khodagholi, & Sanati, ), for vasorelaxation and malaria disease salvigenin effects have been determined (Rafatian, Khodagholi, Farimani, Abraki, & Gardaneh, ).…”

Section: Resultsmentioning

confidence: 99%

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

et al. 2019

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Many taxa of Salvia genus have been used in herbal beverages, food flavoring, cosmetics, and pharmaceutical industry. In this paper, chemical compounds of Salvia eriophora (S. eriophora) leaves were determined by LC–MS/MS (Liquid Chromatography tandem Mass Spectrometry). Salvigenin (158.64 ± 10.8 mg/kg), fumaric acid (123.09 ± 8.54 mg/kg), and quercetagetin‐3.6‐dimethylether (37.85 ± 7.09 mg/kg) were detected as major compounds in the ethanol extract, whereas fumaric acid (555.96 ± 38.56 mg/kg), caffeic acid (103.62 ± 20.51 mg/kg), and epicatechin (83.19 ± 8.43 mg/kg) were detected as major compounds in the water extract. Furthermore, enzyme inhibition of S. eriophora against acetylcholinesterase (AChE), α‐amylase (AM), butyrylcholinesterase (BChE), and α‐glycosidase (AG) enzymes were detected. AChE, BChE, AG, and AM enzymes were very strongly inhibited by S. eriophora water extract (WES) and S. eriophora methanol extract (MES). Additionally, antioxidant potential of S. eriophora was determined by in vitro analytical methods. IC50 values of WES and MES were performed for radicals. Practical applications Metabolic enzymes have crucial functions on living systems due to inhibition or activation of them mainly attributed with some health disorders. AChE, BChE, AM, and AG enzymes have important roles on carbohydrate metabolism or cholinergic pathways. The relation between enzyme inhibition effect and phenolic compounds or antioxidant activity need to be confirmed. Thus, many studies tested to clarify this relation for pure samples or plant extracts. To the best of our knowledge, this is the first report about inhibition effects of Salvia eriophora extracts against AChE, BChE, AM, and AG enzymes as well as their phenolic contents and antioxidant activities.

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Antitumor and immunomodulatory effects of salvigenin on tumor bearing mice

Cited by 26 publications

References 20 publications

Thymus algeriensis and Thymus fontanesii: Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison

Thymus algeriensis and Thymus fontanesii: Chemical Composition, In Vivo Antiinflammatory, Pain Killing and Antipyretic Activities: A Comprehensive Comparison

Comparative Chemomapping of Phytoconstituents from Different Extracts of Globe Artichoke - Cynara Scolymus L.

Phytochemical content, antioxidant activity, and enzyme inhibition effect ofSalvia eriophoraBoiss. & Kotschy against acetylcholinesterase, α-amylase, butyrylcholinesterase, and α-glycosidase enzymes

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