Antitumor Agents LVI: The Protein Synthesis Inhibition by Genkwadaphnin and Yuanhuacine of P-388 Lymphocytic Leukemia Cells

Liou, Y.F.; Hall, Iris H.; Lee, K.H.

doi:10.1002/jps.2600711208

Cited by 33 publications

(15 citation statements)

References 6 publications

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“…Brusatol has been used in traditional Chinese medicine to treat a variety of ailments, including cancer, amoebic dysentery, and malaria. Brusatol inhibits DNA, RNA, and protein synthesis (75, 76), and inhibition of overall protein synthesis by brusatol has been observed in many types of cancer cells (74, 76, 77). Brusatol has recently been reported to act as an NRF2 inhibitor (78), inhibiting NRF2 in all cell lines tested, regardless of whether the KEAP1 or NRF2 genes were mutated.…”

Section: Nrf2 Inhibitorsmentioning

confidence: 99%

The KEAP1–NRF2 System in Cancer

2017

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Cancer cells first adapt to the microenvironment and then propagate. Mutations in tumor suppressor genes or oncogenes are frequently found in cancer cells. Comprehensive genomic analyses have identified somatic mutations and other alterations in the KEAP1 or NRF2 genes and in well-known tumor suppressor genes or oncogenes, such as TP53, CDKN2A, PTEN, and PIK3CA, in various types of cancer. Aberrant NRF2 activation in cancer cells occurs through somatic mutations in the KEAP1 or NRF2 gene as well as through other mechanisms that disrupt the binding of KEAP1 to NRF2. Unregulated NRF2 confers on cancer cells high-level resistance to anticancer drugs and reactive oxygen species (ROS) and directs cancer cells toward metabolic reprogramming. Therefore, NRF2 has been studied as a therapeutic target molecule in cancer. Two strategies have been used to target NRF2 via therapeutic drugs: inhibition of NRF2 and induction of NRF2. NRF2 inhibitors may be effective against NRF2-addicted cancer cells in which NRF2 is aberrantly activated. These inhibitors have not yet been established as NRF2-targeted anticancer drugs for the treatment of human cancers. Diagnosis of NRF2 activation could facilitate the use of NRF2 inhibitors for the treatment of patients with NRF2-addicted cancers. Conversely, NRF2 inducers have been used or are being developed for non-cancer diseases. In addition, NRF2 inducers may be useful for cancer chemotherapy in combination with conventional anticancer agents or even NRF2 inhibitors.

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Section: Nrf2 Inhibitorsmentioning

confidence: 99%

The KEAP1–NRF2 System in Cancer

2017

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“…Extracts of some of Daphne species are widely used for treating cancers, and various compounds isolated from these plants have shown cytotoxic, antimicrobial and antileukemic activities (14,15,18). Different classes of secondary metabolites have been isolated from species belonging to this genus including flavonoids, coumarins, and diterpenoids (1,23,25,26,29).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical and Antimicrobial Screening of Leaves and Stems of Balkan Endemic SpeciesDaphne MalyanaBlečić

Jušković

Vasiljević

Manojlović

et al. 2012

Biotechnology & Biotechnological Equipment

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“…The reported IC 50 values presented in Table 3 show the anti-oxidant potential of these compounds [2]. Literature reveals that the bioactive components from genus Daphne reside in roots, stem or leaves of the plant [21,[27][28][29][30][31]. The ethanolic extract of leaves, stem and roots of Daphne mucronata have been reported to possess antimicrobial effects against Escherichia coli and Pseudomonas aeruginosa whereas the ethanolic extract of root alone has been stated to show activity against Staphylococcus aureus and Bacillus subtilis, however, the toxicity was highest in the leaves extract (LD 50 : 403µg/mL) and lowest in the root extract (LD 50 : > 1000 µg/mL); this association of root extract with low and leaf extract with high toxicity was verified by brine shrimp test.…”

Section: Pharmacological Aspectsmentioning

confidence: 99%