Antitumor Agents 68: Effects of a Series of Helenalin Derivatives on P-388 Lymphocytic Leukemia Nucleic Acid and Protein Synthesis

Cytotoxic Activities of Hypocretenolides from Leontodon hispidus

“…Sesquiterpene lactones are a large class of natural compounds with many types of biological activities. They exhibit cytotoxic and/or antitumor activities; are toxic to vertebrates and invertebrates; have antiphlogistic, antimicrobial, and antiplasmodial effects; and cause allergic contact dermatitis. − The cytotoxicity of several sesquiterpene lactones has been evaluated thus far, but guaianolides of the hypocretenolide-type, like compounds 1 − 3 , have not yet been tested. Hypocretenolides occur in members of the tribe Lactuceae of the family Asteraceae and differ from other guaianolides by an unusual ring closure of the lactone moiety.…”