Inhibition of Nucleic Acid Synthesis in P-388 Lymphocytic Leukemia Tumor Cells by Helenalin and Bis(helenalinyl)malonate In Vivo

Williams, W.L.; Hall, Iris H.; Grippo, Anne A.; Oswald, Christine; Lee, K.H.; Holbrook, David; Chaney, Stephen G.

doi:10.1002/jps.2600770217

Cited by 14 publications

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References 36 publications

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“…The main modes of action are the inhibition of DNA, RNA and protein synthesis. Among others, the specific metabolic targets are the thiol-bearing enzymes IMP dehydrogenase, DNA polymerase a, ribonucleoside reductase (33,36,38), elF-2 kinase, and the elongation factor eIF-3 (29,30). Furthermore, the compounds lower the cellular glutathione level (39,40).…”

Section: Biological Activities Of Arnica Sesquiterpene Lactonesmentioning

confidence: 99%

Arnica Flowers: Pharmacology, Toxicolgy, and Analysis of the Sesquiterpene Lactones—Their Main Active Substances

Willuhn

1998

ACS Symposium Series

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Arnica flowers from the European Compositae Arnica montana have been used in traditional medicine to treat a large variety of different ailments. It has been shown that the known diverse effects of the flowers correlate closely with the pharmacological and toxicological profile of their constituents helenalin, 11α,13-dihydrohelenalin and their esters, which therefore must be considered as their main active compounds. Methods for their qualitative and quantitative determination have been established and the variability in flowers from different geographical origin investigated. Arnica chamissonis ssp. foliosa is used as alternative source for the official "Arnicae flos." In addition to the sesquiterpene lactones of A. montana, they contain 2,3-dihydro-2α-hydroxy-and 2,3-dihydro-2α-,4α-dihydroxy-helenanolide derivatives. The qualitative and quantitative variation is much larger than in the case of A. montana flowers, but populations exist equal to that of A. montana.Arnica flowers from the European Arnica montana L. have been extensively used in traditional medicine to treat a large variety of different ailments. First written records exist from the 16th century when Arnica flowers were used externally and internally in injuries and accidents such as sprains, dislocations, haematomas and oedema associated with fractures. Many vernacular names for this medicinal plant from that time, such as "fall herb", "break herb" or "wound herb" point to this indication. In the following centuries the range of indications for Arnica flowers was enlarged to include treatment of heart and circulatory diseases, chronical diseases such as asthma and rheumatic pains, feverish conditions, menstruation complaints and many other diseases. The plant was named "Panacea lapsorum" after the hypothetical medicine "Panazee," of which the ancient physicians were always dreaming. This imagined 118

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