Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells

Lee, Jangwook; Kim, Jin Kyu; Kim, Dae Won; Hwang, Hyun Sook; Eum, Won Sik; Park, Jinseu; Han, Kyu Hyung; Oh, Joa Sub; Choi, Soo Young

doi:10.1016/j.bbagen.2013.03.030

Cited by 48 publications

(43 citation statements)

References 48 publications

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“…Gallic acid, an anticancer agent, can cause toxic effects by targeting mitochondrial antioxidant enzymes but also has beneficial effects on recovery of ischemic injuries. [278][279][280] Overexpression of the oncogenic variant EGFRvIII and suppression of VEGF signaling are also involved in ROS production and represent an opportunity for the development of a new therapeutic strategy. 281,282 Cardamonin (a chalcon) shows effective anti-inflammatory and anticarcinogenic activity in many cancers.…”

Section: Therapeutic Approaches For Ischemia and Gliomamentioning

confidence: 99%

The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

Ghosh

Chakraborty

Sarkar

et al. 2019

Sig Transduct Target Ther

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Glioma and cerebral ischemic stroke are two major events that lead to patient death worldwide. Although these conditions have different physiological incidences,~10% of ischemic stroke patients develop cerebral cancer, especially glioma, in the postischemic stages. Additionally, the high proliferation, venous thrombosis and hypercoagulability of the glioma mass increase the significant risk of thromboembolism, including ischemic stroke. Surprisingly, these events share several common pathways, viz. hypoxia, cerebral inflammation, angiogenesis, etc., but the proper mechanism behind this co-occurrence has yet to be discovered. The hypercoagulability and presence of the D-dimer level in stroke are different in cancer patients than in the noncancerous population. Other factors such as atherosclerosis and coagulopathy involved in the pathogenesis of stroke are partially responsible for cancer, and the reverse is also partially true. Based on clinical and neurosurgical experience, the neuronal structures and functions in the brain and spine are observed to change after a progressive attack of ischemia that leads to hypoxia and atrophy. The major population of cancer cells cannot survive in an adverse ischemic environment that excludes cancer stem cells (CSCs). Cancer cells in stroke patients have already metastasized, but early-stage cancer patients also suffer stroke for multiple reasons. Therefore, stroke is an early manifestation of cancer. Stroke and cancer share many factors that result in an increased risk of stroke in cancer patients, and vice-versa. The intricate mechanisms for stroke with and without cancer are different. This review summarizes the current clinical reports, pathophysiology, probable causes of co-occurrence, prognoses, and treatment possibilities.

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Section: Therapeutic Approaches For Ischemia and Gliomamentioning

confidence: 99%

The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

Ghosh

Chakraborty

Sarkar

et al. 2019

Sig Transduct Target Ther

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“…GA exhibits variety of biological activities including antioxidant [13][14], anti-tumor [11,[15][16][17], antiinflammatory [18] and anti-bacterial [19][20]. Several line of evidence has shown that GA inhibits tumor cell growth, migration and invasion in vitro [21].…”

Section: /12mentioning

confidence: 99%

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Alonso

Martı́

Barba

et al. 2016

Journal of Photochemistry and Photobiology B: Biology

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In this work, the antioxidant gallic acid (GA) has been encapsulated in microspheres prepared with poly-ε-caprolactone (PCL) and incorporated into polyamide (PA) obtaining the cosmeto-textile. The topical application of the cosmeto-textile provides a reservoir effect in the skin delivery of GA. The close contact of the cosmeto-textile, containing microsphere-encapsulated GA (ME-GA), with the skin and their corresponding occlusion, may be the main reasons that explain the crossing of active principle (GA) through the skin barrier, located in the stratum corneum, and its penetration into the different compartments of the skin, epidermis and dermis. An ex vivo assessment was performed to evaluate the antioxidant effect of the ME-GA on the stratum corneum (SC) using the thiobarbituric acid-reactive species (TBARS) test. The test is based on a non-invasive ex vivo methodology that evaluates lipid peroxides formed in the outermost layers of the SC from human volunteers after UV radiation to determine the effectiveness of an antioxidant. In this case, a ME-GA cosmeto-textile or ME-GA formulation were applied to the skin in vivo and lipid peroxidation (LPO) in the horny layer were determined after UV irradiation. This methodology may be used as a quality control tool to determine ex vivo the percentage of LPO inhibition on human SC for a variety of antioxidants that are topically applied, in this case GA. Results show that LPO formation was inhibited in human SC when GA was applied directly or embedded in the cosmeto-textile, demonstrating the effectiveness of both applications. The percentage of LPO inhibition obtained after both topical applications was approximately 10% for the cosmeto-textile and 41% for the direct application of microspheres containing GA. This methodology could be used to determine the effectiveness of topically applied antioxidants encapsulated in cosmeto-textiles on human SC.

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“…Methyl gallate is derivative of gallic acid. Methyl gallate possesses wide range biological properties that include inhibitor of herpes simplex virus, antioxidant activity, antimicrobial activity, anti-inflammatory, and cancer chemopreventive effect [2,7].…”

Section: Introductionmentioning

confidence: 99%

Methyl Gallate From Jiringa (Archidendron Jiringa) and Antioxidant Activity.

Lubis

Siburian

Marpaung

et al. 2018

Asian J Pharm Clin Res

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Objective: This research was study about phytochemical active phenolic compound from pods of jiringa (Archidendron jiringa (Jack) I. C. Nielsen) and it's antioxidant. Methods:Pods of jiringa were air dried and macerated with methanol. Extract was evaporated using rotary evaporator, and then, crude extract dissolved with water and partitioned with ethyl acetate. Extracts were evaporated and partitioned again with methanol and n-hexane. Column and preparative chromatography used to separate pure compound. Pure compound as methyl gallate was identificated with data from nuclear magnetic resonances of proton H ( 1 H NMR), NMR of carbon ( 13 C NMR), and mass spectrometry (MS). Antioxidant activity of pure compound tested by 1,1-diphenyl-2-picrylhydrazyl method. Results:We found pure phenolic compound from pods of jiringa as methyl gallate that exists on fraction III-2, and it has high antioxidant activity with inhibition concentration 50 was 3.7576 µg/ml. Conclusions:Pods of jiringa contain of active phenolic compound as methyl gallate that has high antioxidant activity. Therefore, it can be used as a source of natural antioxidant.

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Antitumor activity of methyl gallate by inhibition of focal adhesion formation and Akt phosphorylation in glioma cells

Cited by 48 publications

References 48 publications

The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

The interrelationship between cerebral ischemic stroke and glioma: a comprehensive study of recent reports

Skin penetration and antioxidant effect of cosmeto-textiles with gallic acid

Methyl Gallate From Jiringa (Archidendron Jiringa) and Antioxidant Activity.

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