Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

Lang, Sophia J.; Schmiech, Michael; Hafner, Susanne; Paetz, Christian; Steinborn, Carmen; Huber, Roman; Gaafary, Menna El; Werner, Katharina; Schmidt, Christoph Q.; Syrovets, Tatiana; Simmet, Thomas

doi:10.1016/j.phymed.2019.152962

Cited by 76 publications

(60 citation statements)

References 25 publications

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“…The plant contains essential oils, ascorbic acid and traces of alkaloids. Wormwood is traditionally used to treat malaria in the form of tea or pressed juice throughout Asia and Africa [ 28 ]. It is known that sesquiterpene lactone artemisinin, isolated from wormwood, is the main ingredient of malaria medicines [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

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Section: Resultsmentioning

confidence: 99%

Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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“…Fruit extracts had substantial repression of breast cancer cells (MDA-MB-468) growth as well as selective suppression of epidermal growth factor receptor (EGFR) with IC 50 of 4.8 μg/mL [89] Evidence-Based Complementary and Alternative Medicine 7 Acetonitrile extract inhibited the viability of breast (MDA-MB-231 and MCF-7), pancreas (MIA PaCa-2), prostate (PC-3), and non-small-cell lung cancer (A459) cells. e extracts inhibited cancer cell proliferation, decreased tumor growth, and induced apoptosis in vivo in triple negative breast cancer (MDA-MB-231) xenografts grown on the chick chorioallantoic membrane (CAM) assay as well as in nude mice [91]. Hydroalcoholic extract had a cytotoxic effect in a dosedependent manner against D-17 canine osteosarcoma cell lines better than pure artemisinin, indicating a possible synergistic effect of the phytocomplex and a mechanism of action involving iron and possibly ferroptosis [92] Beta vulgaris L.…”

Section: Anticancer Plants Used In Local Communities Of Ugandamentioning

confidence: 99%

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Omara

Kiprop

Ramkat

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The burden of neoplastic diseases is a significant global health challenge accounting for thousands of deaths. In Uganda, about 32,617 cancer cases were reported in 2018, accompanied by 21,829 deaths. In a view to identify some potential anticancer plant candidates for possible drug development, the current study was designed to compile the inventory of plants with reported anticancer activity used in rural Uganda and the evidences supporting their use in cancer therapy. An electronic survey in multidisciplinary databases revealed that 29 plant species belonging to 28 genera distributed among 24 families have been reported to be used in the management of cancer in Uganda. Anticancer plants were majorly from the families Bignoniaceae (7%), Caricaceae (7%), Fabaceae (7%), Moraceae (7%), and Rutaceae (7%). Most species occur in the wild (52%), though some are cultivated (48%). The growth habit of the plants is as trees (55%) or herbs (45%). Anticancer extracts are usually prepared from leaves (29%), bark (24%), roots (21%), and fruits (13%) through decoctions (53%), as food spices (23%) or pounded to produce ointments that are applied topically (10%). Prunus africana (Hook.f.) Kalkman, Opuntia species, Albizia coriaria (Welw. ex Oliver), Daucus carota L., Cyperus alatus (Nees) F. Muell., Markhamia lutea (Benth.) K. Schum., and Oxalis corniculata L. were the most frequently encountered species. As per global reports, Allium sativum L., Annona muricata L., Carica papaya L., Moringa oleifera Lam., Opuntia species, Prunus africana (Hook.f.) Kalkman, and Catharanthus roseus (L.) G. Don. are the most studied species, with the latter having vincristine and vinblastine anticancer drugs developed from it. Prostate, cervical, breast, and skin cancers are the top traditionally treated malignancies. There is a need to isolate and evaluate the anticancer potential of the bioactive compounds in the unstudied claimed plants, such as Cyperus alatus (Nees) F. Muell., Ficus dawei Hutch., Ficus natalensis Hochst., and Lovoa trichilioides Harms, and elucidate their mechanism of anticancer activity.

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“…Table 4 presents the chemical structures and biological activities of major coumarins present in Artemisia annua extracts. Several studies have demonstrated the antioxidant capacity of Artemisia annua [31,39,173], which could be due to the presence of phenolic compounds [30,173].…”

Section: Coumarinsmentioning

confidence: 99%

“…Several studies suggest that artemisinin may not be the most active antitumor compound in Artemisia annua [94,101]. Artemisia annua contains a variety of other biologically active substances [30,101,177], suggesting that this plant could be a source of new herbal anticancer therapies.…”

Section: Cytotoxic and Antitumor Effectsmentioning

confidence: 99%

“…Lang et al [30] demonstrated that Artemisia annua extract free of artemisinin has antitumor activity in vitro and in vivo and identified active compounds. In vitro data were validated in two in vivo cancer models, the chick chorioallantoic membrane ( Essential oil isolated from Artemisia annua (100 µg/mL) induced apoptosis in SMMC-7721 hepatocarcinoma cells by nuclear chromatin fragmentation and cytoplasmic condensation [178].…”

Section: Cytotoxic and Antitumor Effectsmentioning

confidence: 99%

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Artemisia annua, a Traditional Plant Brought to Light

Septembre-Malaterre

Rakoto

Marodon³

et al. 2020

IJMS

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Traditional remedies have been used for thousand years for the prevention and treatment of infectious diseases, particularly in developing countries. Of growing interest, the plant Artemisia annua, known for its malarial properties, has been studied for its numerous biological activities including metabolic, anti-tumor, anti-microbial and immunomodulatory properties. Artemisia annua is very rich in secondary metabolites such as monoterpenes, sesquiterpenes and phenolic compounds, of which the biological properties have been extensively studied. The purpose of this review is to gather and describe the data concerning the main chemical components produced by Artemisia annua and to describe the state of the art about the biological activities reported for this plant and its compounds beyond malaria.

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Antitumor activity of an Artemisia annua herbal preparation and identification of active ingredients

Cited by 76 publications

References 25 publications

Medicinal Plants to Strengthen Immunity during a Pandemic

Medicinal Plants to Strengthen Immunity during a Pandemic

Medicinal Plants Used in Traditional Management of Cancer in Uganda: A Review of Ethnobotanical Surveys, Phytochemistry, and Anticancer Studies

Artemisia annua, a Traditional Plant Brought to Light

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