Antitumor activity and immunomodulatory effects of the intraperitoneal administration of Kanglaite in vivo in Lewis lung carcinoma

Pan, Pei; Wu, Yan; Guo, Zhiyong; Wang, Rong; Wang, Yujie; Yuan, Yongfang

doi:10.1016/j.jep.2012.07.025

Cited by 35 publications

(38 citation statements)

References 36 publications

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“…Coix seed extract can regulate the expression of some apoptotic proteins, including wild type p53 10 , bcl-2 10 , Fas 11 , and caspase-3 12 . It is also known to inhibit nuclear factor (NF)-κΒ-dependent transcription 13, 14 , which is recognized as a target for cancer therapy 15 , and there is a particular interest in the possible use of NF-κΒ inhibitors to enhance the effect of other chemotherapeutic drugs via increased apoptosis 16 . The molecular mechanism of Taxol cytotoxicity has been confirmed.…”

Section: Introductionmentioning

confidence: 99%

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Wang

Zhang

Zhao

et al. 2017

Sci Rep

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Taxol, a first-line anti-tumour drug, has low effectiveness against colorectal cancer. Combination with other agents is an effective strategy to enhance Taxol cytotoxicity. Kanglaite injection is an extract from Coix lacryma-jobi seed and is usually combined with other agents to treat cancer. The aim of this study was to investigate the treatment effect of Taxol combined with Kanglaite on colorectal cancer cell lines. Kanglaite pretreatment followed by Taxol treatment was found to show the best synergism among all combination strategies. This combination also resulted in the smallest tumour volume in a Balb/c mice model. Kanglaite inhibited the expression of nuclear factor (NF)-κΒ and upregulated that of connexin 43, both of which sensitized cancer cells to Taxol. Moreover, Kanglaite increased many cellular variations caused by Taxol, including tubulin polymerization, caspase-3 cleavage, and upregulated expression of survivin and cyclin B1. These results suggest that Kanglaite pretreatment may increase the effect of Taxol on colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Wang

Zhang

Zhao

et al. 2017

Sci Rep

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“…Wu et al found that growth inhibition ratios in hepatoma xenografts were 46.4% and 49.4% after treatment with 5% and 10% KLT for 8 days [6]. Moreover, Pan et al reported that the inhibition ratios were 33.25% and 43.89% after lung cancer xenografts were treated with 6.25 and 12.5 mL/kg of KLT for 14 days [3]. Discrepancies in the experimental methods used in these studies could explain the diversities among these findings.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, traditional Chinese medicine has been widely used in China as adjuvant treatment during chemo- and radiotherapy for cancer [2]. Coix seed is a Chinese herbal medicine that is used in the treatment of hypertension, arthritis, cancer metastasis, asthma, and immunological disorders [3]. The main ingredient of Kanglaite® injection (KLT) is Coix seed oil [4], and it has been widely used for cancer treatment in China [5].…”

Section: Introductionmentioning

confidence: 99%

“…KLT is mainly used for the treatment of non-small-cell lung cancer, liver cancer, and gastric cancer [2,5,9]. KLT has been found to significantly decrease cancer cachexy, improve quality of life of cancer patients, and may ameliorate multiple drug resistance of cancers when combined with radiotherapy and chemotherapy in clinical use [3,4]. …”

Section: Introductionmentioning

confidence: 99%

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Antitumor effect of Kanglaite® injection in human pancreatic cancer xenografts

Liu

Zhang

Wang³

et al. 2014

BMC Complement Altern Med

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BackgroundKanglaite® injection (KLT), with a main ingredient of Coix seed oil (a traditional Chinese medicine), has been widely used for cancer treatment in China. KLT has an inhibitory effect on many kinds of tumors and PI3K/Akt/mTOR signaling promotes cell survival, proliferation, and progression in cancer cells. Therefore, targeting this pathway may lead to the development of novel therapeutic approaches for human cancers.MethodsHere, we examined the effects of KLT on the PI3K/Akt/mTOR pathway in pancreatic cancer xenografts in mice, and assessed its therapeutic potential. Growth and apoptosis of tumor xenografts were examined, and the expression levels of genes and proteins involved in the PI3K/Akt/mTOR pathway were measured by RT-PCR and western blotting, respectively.ResultsOur results revealed that KLT dramatically inhibited the growth of pancreatic cancer xenografts and induced apoptosis simultaneously. Furthermore, it downregulated the expression of phospho-Akt and phospho-mTOR.ConclusionsThese results suggest that KLT can suppress growth and induce apoptosis of pancreatic cancer xenografts. Moreover, KLT can downregulate the expression of phospho-Akt and phospho-mTOR to modulate the PI3K/Akt/mTOR signaling pathway.

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“…To improve the curative effect of TCM, except the traditional oral route, new administration methods of TCM should be investigated and developed; e.g., intraperitoneal administration [124], intranasal administration [125]. In addition, improving the bioavailability can be regarded as another way to promote the therapeutic effect of TCM.…”

Section: Exploring the New Therapeutic Modalities Of Tcm For Treatmenmentioning

confidence: 99%

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

Feng¹,

Zhu²,

Hu³

et al. 2017

Cancer Rep Rev

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Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide with a high mortality, and still there are only few effective methods to treat it. To this end, alternative medicines from traditional Chinese medicine (TCM) are being investigated for their ability to eliminate the tumor or halt its progression. A large number of studies have shown that TCM can be an effective approach to treat the HCC in clinical trials when used alone or in combination with other therapies. Thus, TCM has made significant progress, and has begun to gain worldwide popularity for promoting healthcare and HCC treatment. Because of this progress, periodic summaries are needed to facilitate further research for the use of TCM to treat HCC. This paper provides a comprehensive summary of this work with regard to the following aspects: herbalist views on the etiology and therapeutic principles for treatment of HCC, treating HCC by TCM alone, treating HCC with TCM in combination with resection, chemotherapy, radiotherapy and interventional therapy, and other therapies. Additionally, the current main problems and future application prospects for treatment of HCC by TCM described, which could provide scientific guidance for clinician as well as references for the treatment of other cancers.

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Antitumor activity and immunomodulatory effects of the intraperitoneal administration of Kanglaite in vivo in Lewis lung carcinoma

Cited by 35 publications

References 36 publications

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒ inhibition and connexin 43 upregulation

Antitumor effect of Kanglaite® injection in human pancreatic cancer xenografts

Traditional Chinese medicine combined with other therapies for treatment of hepatocellular carcinoma in clinical trials

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