Antituberculosis drug isoniazid degraded by electro-Fenton and photoelectro-Fenton processes using a boron-doped diamond anode and a carbon-PTFE air-diffusion cathode

Abstract

Solutions with 0.65 mM of the antituberculosis drug isoniazid (INH) in 0.050 M NaSO at pH 3.0 were treated by electro-Fenton (EF) and UVA photoelectro-Fenton (PEF) processes using a cell with a BDD anode and a carbon-PTFE air-diffusion cathode. The influence of current density on degradation, mineralization rate, and current efficiency has been thoroughly evaluated in EF. The effect of the metallic catalyst (Fe or Fe) and the formation of products like short-chain linear aliphatic carboxylic acids were assessed in PEF. Two consecutive pseudo-first-order kinetic regions were found using Fe as catalyst. In the first region, at short time, the drug was rapidly oxidized by OH, whereas in the second region, at longer time, a resulting Fe(III)-INH complex was much more slowly removed by oxidants. INH disappeared completely at 300 min by EF, attaining 88 and 94% mineralization at 66.6 and 100 mA cm, respectively. Isonicotinamide and its hydroxylated derivative were identified as aromatic products of INH by GC-MS and oxalic, oxamic, and formic acids were quantified by ion-exclusion HPLC. The PEF treatment of a real wastewater polluted with the drug led to slower INH and TOC abatements because of the parallel destruction of its natural organic matter content.

Adsorption Characteristics of Pristine and Magnetic Olive Stones Biochar with Respect to Clofazimine

“…On the other hand, a literature survey shows little effort being reported to remove the anti-TB drugs from wastewater. Efforts were mainly focused on using advanced oxidation processes (AOPs), electro-Fenton and photoelectro-Fenton technologies [15,16]. Scheme 1.…”

“…Applications included the removal of organics, e.g., PhACs, pesticides, dyes, etc. [13][14][15][16][17][18][19][20][21][22], as well as inorganics [23,24]. By and large, biochars obtained from agro-wastes possess high surface area, unique pore size and pore distribution, in addition to being cost-effective.…”

Activation of hydrogen peroxide by graphite supported H2SO4-CeO2 for isoniazid degradation under neutral pH

“…In recent years, the INH has been often detected in the aquatic environment, representing a potential risk (Coronado-Castañeda et al 2020). Therefore, many efforts have been used to eliminate INH, such as the application of advanced oxidation process (AOPs) (Guevara-Almaraz et al 2015;Jo & Sivakumar Natarajan 2015;Nekoeinia et al 2018;Stets et al 2018;Guelfi et al 2019). Among the various AOPs, Fenton-like process has been widely implemented to remove organic compounds (Xu & Wang 2011;Güneşet al 2019).…”