Antituberculosis agents—I

Heterocyclic synthesis containing bridgehead nitrogen atom: Synthesis of 3‐[(2H)‐2‐oxobenzo[b]pyran‐3‐yl]‐s‐triazolo[3,4‐b]‐1,3,4‐thiadiazine and thiazole derivatives

“…Triazolom and Alprazolam [12,13]. Additionally, several of the 3-substituted thio-1,2,4-triazoles have shown biological activity against tuberculosis [14,15], as anticoccidal agents in chicken [16], and in cephalosporins as antibacterial agents [17].…”

Novel isochroman-triazoles and thiadiazole hybrids: Design, synthesis and antimicrobial activity

“…A celebrated example is that of fluconazole, an antifungal agent for the treatment of superficial and systemic infections [14]. Others possess diuretic [15], antibacterial [16], hypoglycemic [17] and antitubercular [18] activities. Moreover, these are inhibitors of corrosion of copper, brass, aluminum and steel in marine environment [19] and inhibitors of fog formation in photographic emulsions [20].…”

DFT Investigation of Chelation of Divalent Cations by Some 4-Benzylidenamino-4,5-Dihydro-1H-1,2,4-Triazol-5-One Derivatives

“…In general, 1,2,4 triazole derivatives are biologically versatile compounds displaying a variety of biological effects which include anti-imflammatory [1], antimycobacterial [2][3], antifugal [4], antibacterial [5][6] and antiviral activities [3]. The 4-benzylidenamino-4,5-dihydro-1H-1,2,4-triazol-5-one derivatives obtained through the reaction [7] of 3-alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones with 3,4 dihydroxy benzaldehyde, possess various biological properties such as anticonvulsant [7], antifungal [8][9], antituberculosis [10] and antiproliferative [11] activities. In addition, 4,5-dihydro-1H-1,2,4-triazol-5-one derivatives which exhibit important pharmacological activities such as antivirius [12] and antioxidant [13][14] have found wide use in medicinal chemistry as common structures.…”