Antituberculosis Activity of Active Compound of Ethyl Acetate Extract for Patikan Kebo (Euphorbia hirta L.)

Abstract

Infectious diseases caused by bacteria are a concern in the world of health. The microbe Mycobacterium tuberculosis which causes tuberculosis (TB) is one of the main disease problems in the world, as evidenced by the existence of 10.4 million sufferers and 1.8 million deaths in the world in 2015. During 5 years (2015 to 2020), the World Health Organization was done some comprehensive programs it can reduce mortality up to 13%. However, since early 2020 were increased the mortality rate again as in 2015. In addition, the increasing incidence of bacterial resistance to antibiotics has triggered various studies to find alternative antibacterial agents. This study is related to the anti-tuberculosis activity (against M. tuberculosis strain H37Rv with the liquid dilution method with Middlebrook 7H9 (MB 7H9) and solid dilution with Lowenstein-Jensen (LJ)) in ethyl acetate patikan kebo (Euphorbia hirta L.) extract. The investigation of antimycobacterial tuberculosis, it was found that a concentration of 800 µg/mL had anti-tuberculosis activity against Mycobacterium tuberculosis H37Rv. The active compound as a result of isolation is the triterpenoid (taraxasterol) group.

Exploration of Potentially Bioactive Compounds from Fingerroot (Boesenbergia rotunda L.) as Inhibitor of Atherosclerosis-Related Proteins (CETP, ACAT1, OSC, sPLA2): An in silico Study

“…Previous studies suggested that inhibition of sPLA2 activity could prevent atherosclerosis 40 . In brief, medicinal plants compound had an essential role for therapeutic development 41 . Moreover, plants serve as rich sources of drug compounds in traditional medicine 42 .…”

Identification of Pharmaceutically Important Constituents of Quinoa Root

“…and 1,12-tridecadiene(8) were showing 4.30%, 3.63%, 3.08%, 2.27% and 2.00% peak areas, respectively.The compounds present in less concentrations were artumerone, 2-methyl-6-(4-methylphenyl)-2-hepten-4-one (3); tetradecanoic acid (4); 2-benzoyl-d-galactosan (6); pentadecane (5); 10,13-eicosadienoic acid, methyl ester(13); dodecanoic acid (1) and hexadecane (2) with peak areas ranging from 1.68 to 0.77%.…”

“…[7] In addition, they presumed a preventive role to indicate their diverse beneficial functions against soilborne fungal pathogens, human pathogens and food-borne diseases. [8][9][10] Quinoa (Chenopodium quinoa Willd.) is an ancient crop grown widely in South America, Chile, China, Argentina, Bolivia, Ecuador, Colombia, Peru, Canada and France.…”