Antithrombogenic and antiplatelet activity of optho-isobornyl phenol derivative

Abstract

We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.

Hemorheologic Effects of Dibornol in a Model of Myocardial Ischemia/Reperfusion

“…The used model of myocardial ischemia/reperfusion triggers the development of oxidative stress associated with oxidative modifi cation of erythrocyte membranes and changes in their functional properties observed by us. Given the high antioxidant activity of compounds belonging to the group of sterically hindered phenols, the study of dibornol, one of the active compounds, is quite justifi ed under these conditions [5].…”

“…A series of derivatives of o-isobornylphenol belonging to the group of sterically hindered phenols was synthesized at the Institute of Chemistry, Komi Scientifi c Center, Ural Division of Russian Academy of Sciences. Members of this group have a high antioxidant activity [3] and may be of interest as correctors of blood rheology in pathological conditions involving increased blood viscosity syndrome [5].…”

Anti-inflammatory activity of isobornylphenol derivatives

“…The literature teaches that phenols with a bicyclic isobornyl moiety exhibit anti-infection activity [3]. The series of studies performed by us on the synthesis and investigation of terpenophenols showed that some alkylphenols exhibit hemorheological properties and improve brain blood flow [4,5]. Thus, the synthesis of terpenophenols is critical for further studies of their physiological properties.…”

Synthesis oftertiaryamidomethyl derivatives of 2-isobornyl-4-methylphenol

“…It was shown recently that phenols with an isobornyl substituent exhibit antithrombogenic and antithrombocytic activities [2] and are used as local infection agents [3].Amides are natural compounds with varied and exceedingly effective biological activity [4]. The amide group often acts as a linker for binding various structural fragments in order to create new biological molecules [5].…”

“…It was shown recently that phenols with an isobornyl substituent exhibit antithrombogenic and antithrombocytic activities [2] and are used as local infection agents [3].…”