Hemorheologic Effects of Dibornol in a Model of Myocardial Ischemia/Reperfusion

Плотникова, Т. М.; Чернышева, Г. А.; Smol’yakova, V. I.; Щетинин, П. П.; Кучин, А. В.; Chukicheva, I. Yu.; Плотников, М. Б.

doi:10.1007/s10517-014-2527-8

Cited by 20 publications

(7 citation statements)

References 6 publications

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“…As shown previously, compound 1 exhibits AO properties in vitro, [18,19] surpassing the activity of BHT by a number of parameters, and is characterized by low hemolytic efficiency. [20] During the experiments on laboratory animals, compound 1 showed rheologic activity in ischemia/reperfusion [21] conditions and cardioprotective properties. [22] There have also been earlier cases of using 2,6-diisobornyl-4-methylphenol (1) in the synthesis of new derivatives.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

Буравлев

Dvornikova

Schevchenko

et al. 2019

Chemistry & Biodiversity

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A series of novel esters and amides was synthesized on the basis of para‐coumaric acid containing isobornyl groups in ortho‐positions relative to the phenolic hydroxy group. Antioxidant properties of the obtained compounds were evaluated and compared on in vitro models: radical‐scavenging ability, antioxidant activity on a substrate containing the lipids of animal brain, cytotoxicity of red blood cells, antioxidant and membrane‐protective properties on the model of oxidative red blood cells hemolysis. Statistically significant relationship was established between the antioxidant activity of the studied compounds in model system containing animal lipids and the parameters reflecting their antioxidant properties on the model of H2O2‐induced hemolysis of red blood cells. It was determined that an amide with a morpholine fragment has the highest antioxidant activity. The specified derivative significantly surpassed the reference substances (parent acid, BHT) and was not inferior to the effective antioxidant 2,6‐diisobornyl‐4‐methylphenol in terms of its properties.

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Section: Resultsmentioning

confidence: 99%

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

Буравлев

Dvornikova

Schevchenko

et al. 2019

Chemistry & Biodiversity

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“…A series of terpenophenols was previously synthesized and its structure-activity relationship was evaluated. [23,24] It was revealed that insertion of monoterpene substituent in the phenols molecules reduces hemolytic and significant increases antioxidant activity (AOA). [25] This work is a continuation study of the synthetic potential of terpenophenols to obtain highly biologically active compounds.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Biological Evaluation of Novel Coumarins withtert‐Butyl and Terpene Substituents

Попова

Шевченко

Chukicheva

et al. 2019

Chemistry & Biodiversity

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Coumarins with terpene and tert‐butyl substituents were synthesized via Pechmann condensation reaction. New derivatives were investigated in different model system for the exhibition of antioxidant, radical scavenging and membrane‐protective activities. It has been found that 4‐methylcoumarin derivatives with monoterpene moieties exhibit high antioxidant activities. The most active and promising for further investigations is 5‐hydroxy‐6,8‐diisobornyl‐4‐methylcoumarin, containing two isobornyl substituents on the benzopyran ring.

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“…2)). The experiment revealed high antihypoxic activity of dibornol in the model of acute hypobaric hypoxia, and hemorheological activity in a model of ischemia/reperfusion [7]. When modeling incomplete cerebral ischemia with oxidative stress, a course of treatment with dibornol significantly limited the accumulation of primary and secondary products of lipid peroxidation.…”

Section: Fig 1 Shp Redox Reactions With Free Radicalsmentioning

confidence: 97%

“…Dibornol (4-methyl-2,6-diisobornylphenol) is the first drug from the group of hindered terpenophenols that proceeded to preclinical studies. It has been established that dibornol has powerful antioxidant properties, as well as hemorheological, antiplatelet and antithrombogenic types of activity [7]. The high antiradical activity is determined by the chemical formula of this compound (viz.…”

Section: Fig 1 Shp Redox Reactions With Free Radicalsmentioning

confidence: 99%

The Antiarrhythmic Effect of 4-Methyl-2,6-Diisobornylphenol in Myocardial Ischemia/Reperfusion

Плотникова

Плотников

Чернышева

et al. 2016

KEM

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We studied the antiarrhythmic activity of novel sterically hindered phenols – 4-methyl-2,6- diisobornylphenol (dibornol) in acute myocardial ischemia/reperfusion in male Wistar rats. Left coronary artery occlusion (10 min) in control group induced different ventricular arrhythmia and 23% mortality of animals. Dibornol (p.o. administration 100 mg/kg 24 and 3 hours before ischemia) did not change the frequency and kinds of arrhythmia in acute ischemia, but significantly reduced the frequency and the level of seriousness of arrhythmia in the reperfusion period, decreased the mortality of rats due to lethal arrhythmia.

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Hemorheologic Effects of Dibornol in a Model of Myocardial Ischemia/Reperfusion

Cited by 20 publications

References 6 publications

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

Synthesis and Antioxidant Ability of Novel Derivatives Based on para‐Coumaric Acid Containing Isobornyl Groups

Synthesis and Biological Evaluation of Novel Coumarins withtert‐Butyl and Terpene Substituents

The Antiarrhythmic Effect of 4-Methyl-2,6-Diisobornylphenol in Myocardial Ischemia/Reperfusion

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