Antithrombogenic and Antiplatelet Activities of Extract from Maackia amyrensis Wood

Abstract

Antithrombogenic and antiplatelet effects of a new drug, containing isoflavonoids (extract from the wood of Maackia amyrensis, a Far Eastern plant), were studied. A course (200 mg/kg intragastrically during 14 days) of Maackia amyrensis extract prevented intravascular clotting, initiated by application of 10% iron chloride solution on the vessel. The drug increased antiaggregant activity of the vascular wall and potentiated endothelium-dependent vasodilatation in ovariectomied rats. The reference drug ethinylestradiol (25 mug/kg intragastrically during 14 days) potentiated the antiaggregant effect of the endothelium, but was inferior to Maackia amyrensis extract in the capacity to induce endothelium-dependent vasodilatation in ovariectomied rats.

Antioxidant Activity of the Isoflavonoids from the Roots of Maackia amurensis

“…The Maksar preparation increases the anti-aggregative activity of the vascular walls and potentiates endothelium-dependent vasodilatation in ovariectomized rats [8,9]. It also possesses antithrombogenic, antiplatelet and anticancer properties [9,10].…”

“…In addition to possessing a hepatoprotective effect, the Maksar preparation increases the activity of the antioxidant system, reduces lipid peroxidation, prevents increases in the total serum lipid content and prevents the development of alimentary hyperlipoproteinemia in experimental animals [5][6][7]. The Maksar preparation increases the anti-aggregative activity of the vascular walls and potentiates endothelium-dependent vasodilatation in ovariectomized rats [8,9]. It also possesses antithrombogenic, antiplatelet and anticancer properties [9,10].…”

“…The Maksar preparation increases the anti-aggregative activity of the vascular walls and potentiates endothelium-dependent vasodilatation in ovariectomized rats [8,9]. It also possesses antithrombogenic, antiplatelet and anticancer properties [9,10]. Dried M. amurensis stem bark, which is often used in folk medicine for the treatment of cancer, cholecystitis and arthritis, is a good source of prenylated isoflavones, flavanones and pterocarpans [11].…”

Cytotoxic Prenylated Polyphenolic Compounds from Maackia amurensis Root Bark

“…It prevents the increase in total serum lipid content and the development of hyperlipoproteinemia in experimental animals [4,7]. Maxar ® also possesses antithrombogenic, antiplatelet and antitumor properties [8,9]. The M. amurensis stem bark has been used in folk medicine for the treatment of cancer, cholecystitis and arthritis.…”

Diacylglycerol Acyltransferase-inhibitory Prenylated Flavonoids from Maackia amurensis Rupr

“…Its constituents have been shown for antimicrobial, antiviral, hypolipidemic, antithrombogenic, and antiplatelet activities. [1][2][3] Flavonoids, alkaloids and polyphenolic have been reported as main constituents of this genus. 4 As a part of our exploration on the medicinal plant, the MeOH extract of the stem bark of this plant was studied.…”