Antithetical effect of tumor necrosis factor-αgene polymorphism on coal workers' pneumoconiosis (CWP)

Wang, Xintao; Ohtsuka, Yoshinori; Kimura, Kazuhiro; Muroi, Miho; Ishida, Takashi; Saito, Junpei; Munakata, Mitsuru

doi:10.1002/ajim.20180

Cited by 21 publications

(23 citation statements)

References 29 publications

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“…In a previous study conducted by our group (25), the frequency of the TNF-α-308 A allele was found to be higher in patients with nodular CWP compared to those with PMF. In this study, there were only five cases with the analyzed TNF-α promoter gene.…”

Section: T a B L E 4 Ag E Du S T E X P O S U R E Hi S T O R Y Smentioning

confidence: 69%

“…However, the number of subjects is too small to comment on concerning the relationship between the TNF-α gene and pneumoconiosis. Although reports on genetic factors concerning pneumoconiosis are somewhat in conflict at this time (22,23,25), further studies on the mechanisms of the progression of CWP are highly likely. At present, we do not have any effective way to stop or slow down the progression of these pathological changes.…”

Section: T a B L E 4 Ag E Du S T E X P O S U R E Hi S T O R Y Smentioning

confidence: 95%

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Progression of Pneumoconiosis in Coal Miners after Cessation of Dust Exposure: A Longitudinal Study Based on Periodic Chest X-ray Examinations in Hokkaido, Japan

et al. 2010

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Background The progression rate of pneumoconiosis in retired coal miners over ten years has not been studied in Japan. Methods A retrospective longitudinal study was undertaken using chest X-rays of 1091 pneumoconiosis subjects in Hokkaido, Japan between 1985 and 2005. Results The final numbers of subjects were 207 (19% of the entry) after 1 decade and 85 (8%) after 2 decades. Sixty-two percent of 207 subjects after 1 decade and 29% of 85 showed progression in 2 decades. Thirty-one percent of ILO category 1 and 55% of category 2 subjects showed progression to complicated pneumoconiosis after 1 decade, and 6% (4 of 64) of category 1 and 6% (5 of 77) of category 2 subjects progressed to complicated pneumoconiosis during 2 decades. Conclusion The progression of pneumoconiosis was observed after the cessation of dust exposure, especially during the first 10 years.

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Section: T a B L E 4 Ag E Du S T E X P O S U R E Hi S T O R Y Smentioning

confidence: 69%

Section: T a B L E 4 Ag E Du S T E X P O S U R E Hi S T O R Y Smentioning

confidence: 95%

Progression of Pneumoconiosis in Coal Miners after Cessation of Dust Exposure: A Longitudinal Study Based on Periodic Chest X-ray Examinations in Hokkaido, Japan

et al. 2010

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“…It has been shown that the TNF-a -238 and -308 variants are associated with silicosis [20,21]. In a recent study investigating TNF-a gene variations in Japanese miners with CWP and PMF, no association was found between the TNF-a -238 and -308 variants and PMF [22], and it was suggested that these variants may not be related to the severity of CWP. The present results confirm this conclusion in a significantly larger group of coal miners.…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to progressive massive fibrosis in coal miners

Yücesoy¹,

Johnson²,

Kissling³

et al. 2008

European Respiratory Journal

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Progressive massive fibrosis (PMF) is a chronic interstitial lung disease with a complex aetiology that can occur after cumulative dust exposure. A case-control study was conducted to test the hypothesis that single nucleotide polymorphisms (SNPs) within genes involved in inflammatory and fibrotic processes modulate the risk of PMF development.The study population consisted of 648 underground coal miners participating in the National Coal Workers Autopsy Study, of which 304 were diagnosed with PMF. SNPs that influence the regulation of interleukin (IL)-1, IL-6, tumour necrosis factor-a, transforming growth factor-b1, vascular endothelial growth factor (VEGF), epidermal growth factor intercellular cell adhesion molecule (ICAM)-1 and matrix metalloproteinase-2 genes were determined using a 59-nuclease real-time PCR assay.There were no significant differences in the distribution of any individual SNP or haplotype between the PMF and control groups. However, the polygenotype of VEGF +405/ICAM-1 +241/IL-6 -174 (C-A-G) conferred an increased risk for PMF (odds ratio 3.4, 95% confidence interval 1.3-8.8).The present study suggests that the examined genetic variations that help regulate inflammatory and fibrotic processes are unlikely to strongly influence susceptibility to this interstitial lung disease, although the role of vascular endothelial growth factor, intercellular cell adhesion molecule-1 and interleukin-6 polymorphisms in the development of progressive massive fibrosis may require further investigation.

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“…Polymorphisms at À238 and À308 have been proposed as being responsible for the variation of TNFA production [D'Alfonso and Richiardi, 1994]. An association between À308 variant and CWP in Europeans [Zhai et al, 1998], in South Africans [Corbett et al, 2002] and in Japans [Wang et al, 2005] has been found. In Europeans and Japans, it has been found that À308 variant was related to the development of CWP.…”

Section: Discussionmentioning

confidence: 99%

Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

Ateş

Süzen

Yücesoy

et al. 2008

American J Industrial Med

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Antithetical effect of tumor necrosis factor-αgene polymorphism on coal workers' pneumoconiosis (CWP)

Abstract: TNF-alpha-308 A allele might interact with smoking to enhance susceptibility to nodular CWP.

Cited by 21 publications

References 29 publications

Progression of Pneumoconiosis in Coal Miners after Cessation of Dust Exposure: A Longitudinal Study Based on Periodic Chest X-ray Examinations in Hokkaido, Japan

Progression of Pneumoconiosis in Coal Miners after Cessation of Dust Exposure: A Longitudinal Study Based on Periodic Chest X-ray Examinations in Hokkaido, Japan

Genetic susceptibility to progressive massive fibrosis in coal miners

Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

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