Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

Ateş, İlker; Süzen, Sinan; Yücesoy, Berran; Tekin, İshak Özel; Karakaya, Asuman

doi:10.1002/ajim.20632

Cited by 22 publications

(19 citation statements)

References 43 publications

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“…It is reported that the increasing prevalence and severity of coal workers' pneumoconiosis is due to increasing silica exposure in the United States [3]. In response to inhaled silica, alveolar macrophages and cytokines such as TGF-β1, interleukin (IL)-1β, IL-6 and IL-13 produced by these cells, have been suggested to play a central role during the early inflammatory response affecting the interactions among pro-and anti-inflammatory mechanisms that result in CWP [4]. Many factors attribute to CWP, including the workplace characteristics and susceptible individuals [5], [6].…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Hou

Wang

et al. 2012

PLoS ONE

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BackgroundCoal workers' pneumoconiosis (CWP), resulting from the inhalation of silica-containing coal mine dust, is characterized by fibrosing nodular lesions that eventually develop into progressive pulmonary fibrosis. Recently, it has been hypothesized that inflammasomes could have a crucial role in the host response to silica and recent studies show that the inflammasome contributes to inflammation and pulmonary fibrosis. NLRP3, CARD8 are components of the NLRP3 inflammasome, which triggers caspase 1-mediated IL-1β and IL-18 release. In the present study, we investigated whether common single nucleotide polymorphisms (SNPs) in inflammasome genes are associated with CWP.MethodsWe performed an association study analyzing 3 NLRP3, 1 CARD8, 1 IL-1β, 2 IL-18 SNPs in a case-control study of 697 CWP and 694 controls. Genotyping was carried out by the TaqMan method.ResultsThe NLRP3 rs1539019 TT genotype was associated with a significantly increased risk of CWP (adjusted odds ratio (OR) = 1.39, 95% confidence interval (CI) = 1.07–1.81), compared with the GG/GT genotype, in particular among smokers (adjusted OR = 1.67, 95%CI = 1.15–2.42). In addition, the polymorphism was significantly associated with risk of CWP patients with stage I.ConclusionsThis is the first report showing an association between the NLRP3 rs1539019 polymorphism and CWP, and suggests that this polymorphism may confer increased risk for the development of the disease. Further studies are warranted to confirm our findings.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Hou

Wang

et al. 2012

PLoS ONE

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“…Genetic factors such as polymorphisms can contribute to the extent or severity of CWP. Many genetic studies in CWP patients have involved genes encoding for cytokines and their receptors [12], [13], [14]. Cytokines play a crucial role in the widely used immunological model that explain the increasing prevalence of inflammatory diseases by an altered balance between Th1 and Th2 immune response [15].…”

Section: Discussionmentioning

confidence: 99%

Associations of IL-4, IL-4R, and IL-13 Gene Polymorphisms in Coal Workers' Pneumoconiosis in China: A Case-Control Study

Wang

Song

et al. 2011

PLoS ONE

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BackgroundThe IL-4, IL-4 receptor (IL4R), and IL-13 genes are crucial immune factors and may influence the course of various diseases. In the present study, we investigated the association between the potential functional polymorphisms in IL-4, IL-4R, and IL-13 and coal workers' pneumoconiosis (CWP) risk in a Chinese population.MethodsSix polymorphisms (C-590T in IL-4, Ile50Val, Ser478Pro, and Gln551Arg in IL-4R, C-1055T and Arg130Gln in IL-13) were genotyped and analyzed in a case-control study of 556 CWP and 541 control subjects.ResultsOur results revealed that the IL-4 CT/CC genotypes were associated with a significantly decreased risk of CWP (odds ratio (OR) = 0.74, 95% confidence interval (CI) = 0.58–0.95), compared with the TT genotype, particularly among subgroups of age <65 years (OR = 0.68, 95%CI = 0.46–0.99) and dust exposure years ≥26 years (OR = 0.69, 95%CI = 0.50–0.94). Moreover, the polymorphism was significantly associated with risk of CWP patients with stage I. In addition, a combined effect was observed in a dose-dependent manner with increasing numbers of risk variant alleles (P trend = 0.023), and individuals with 11–12 risk alleles had a 47% higher risk of CWP than those with 0–8 risk alleles (OR = 1.47, 95% CI = 1.05–2.05).ConclusionsOur results suggest that the IL-4 C-590T polymorphism is involved in the etiology of CWP and susceptibility to this disease. Larger studies are warranted to validate our findings.

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“…While the LTA NcoI polymorphism found associated with CWP prevalence in miners with low blood catalase activity, the TNFa -308 SNP showed an interaction with erythrocyte GSH-Px activity in individuals with high occupational exposure (Nadif et al, 2003). The TNFa -238 and -308 polymorphisms were associated with CWP development and severity in Turkish coal miners, respectively (Ates et al, 2008). They also reported a protective effect of the IL-6 -174 variant in the development and severity of CWP.…”

Section: Coal Workers' Pneumoconiosismentioning

confidence: 93%

“…In this respect, a number of susceptibility markers have been identified in several occupational lung diseases, such as silicosis, asthma, CBD, and CWP (Yucesoy et al, 2001a;McCanlies et al, 2004;Ates et al, 2008;Bernstein et al, 2006). These studies have provided strong evidence that the pathogenesis of occupational lung diseases involves geneeenvironment interactions.…”

Section: Geneeenvironment Interactionsmentioning

confidence: 97%

Role of Genetic Factors in Pulmonary Disease Susceptibility

Yücesoy¹,

Johnson²,

Luster³

2015

Comparative Biology of the Normal Lung

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Association of cytokine gene polymorphisms in CWP and its severity in Turkish coal workers

Abstract: We suggest that TNFA (-238) variant may be a risk factor in both development and the severity of CWP, while TNFA (-308) variant seems to be important only in disease severity. On the other hand, IL6 variant may have a protective effect on the development and disease severity.

Cited by 22 publications

References 43 publications

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Polymorphisms in Inflammasome Genes and Risk of Coal Workers' Pneumoconiosis in a Chinese Population

Associations of IL-4, IL-4R, and IL-13 Gene Polymorphisms in Coal Workers' Pneumoconiosis in China: A Case-Control Study

Role of Genetic Factors in Pulmonary Disease Susceptibility

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