Antissaliva Antibodies of Lutzomyia Longipalpis in area of Visceral Leishmaniasis

Fraga, Thiago Leite; Fernandes, Magda Freitas; Pontes, Elenir Rose Jardim Cury; Levay, Ana Paula Silva; Cunha, Elenice Brandão Almeida da; França, Adriana de Oliveira; Dorval, Maria Elizabeth Cavalheiros

doi:10.1097/inf.0000000000001172

Cited by 4 publications

(2 citation statements)

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“…Validated in Brazil and elsewhere [ 36 , 37 ], the rk39 rapid test has been used to detect asymptomatic and subclinical infections [ 29 ]. In the reevaluation, only two samples were positive on ELISA, while all were negative on the rapid test—a detection failure also observed in other studies [ 38 , 39 ].…”

Section: Discussionsupporting

confidence: 72%

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

et al. 2018

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Transfusion-transmitted leishmaniasis has been a concern in regions endemic for the disease. Whether immediate or delayed, the risks posed by this mode of transmission call for careful assessment. The purpose of this study was to detect Leishmania infection in blood donors living in an endemic area and to investigate progression to the disease in these individuals. Immunofluorescent antibody test, enzyme-linked immunosorbent assay, leishmaniasis rapid test, and the polymerase chain reaction were applied to 430 donors in an initial evaluation. Of those donors with at least one positive test, 50 were reevaluated four years later by the same methods, as were 25 controls who had been negative on the same tests. In the first evaluation, Leishmania infection was detected in 41.4% (95% CI: 36.7–46.1) of donors (n = 430). None of the 75 reevaluated individuals had developed the disease, but retesting revealed positivity in at least one test in 36.0% (95% CI: 25.1–46.9) of donors. Of the 50 initially testing positive, 50% remained so on retesting. Of the 25 initially negative controls, two tested positive in the subsequent evaluation. The severity of the parasitosis and the risk of transfusion transmission warrant investigation of the potential inclusion of methods for Leishmania detection into blood banks for effective screening of infected donors.

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Section: Discussionsupporting

confidence: 72%

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

et al. 2018

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“…All samples were negative on the rapid test with rK39 antigen, corroborating results of previous studies (Clemente et al, 2014;Fraga et al, 2016). Although intended for VL diagnosis (Cañavate et al, 2011;Peruhype-Magalhães et al, 2012), this method has also been used to detect asymptomatic and subclinical infections (Barão et al, 2007;França et al, 2018).…”

Section: Discussionsupporting

confidence: 85%

Presence of anti-Leishmania antibodies in candidates for kidney transplantation

França

Cunha

Oliveira

et al. 2020

International Journal of Infectious Diseases

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Objectives: Visceral leishmaniasis (VL) is a progressive disease that, left untreated, is typically fatal. The purpose of this investigation was to detect Leishmania sp. infection in hemodialysis patients who had received multiple blood transfusions at a private clinic in Campo Grande, Mato Grosso do Sul state, Midwest Brazil. Methods: Fifty randomly selected volunteers were interviewed for collection of demographic, socioeconomic, and epidemiological data. Indirect immunofluorescence (titers positive when !1:40) and rK39 immunochromatographic tests were employed for serological investigation. Results: Males predominated (60%). Age ranged from 20 to 77 years. Most subjects reported being on hemodialysis for at least one year (94%) and 84% were candidates for kidney transplantation, 67% of whom were on the waiting list. Leishmania sp. infection was detected in 32%. Contact with infected dogs was the only variable associated with infection. Conclusions: Under immunocompromised conditions, VL is opportunistic and potentially fatal. Despite existing risks, screening for VL is not performed in asymptomatic donors and recipients. The detection of anti-Leishmania antibodies in these patients reinforces the need for infection screening before immunosuppressive treatment is initiated to reduce not only the risks of VL development and severity, but also mortality rates in cases of reactivation of latent infection.

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Lutzomyia longipalpis: an update on this sand fly vector

Rêgo

Soares

2021

An. Acad. Bras. Ciênc.

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Lutzomyia longipalpis is the most important vector of Leishmania infantum, the etiological agent of visceral leishmaniasis (VL) in the New World. It is a permissive vector susceptible to infection with several Leishmania species. One of the advantages that favors the study of this sand fly is the possibility of colonization in the laboratory. For this reason, several researchers around the world use this species as a model for different subjects including biology, insecticides testing, host-parasite interaction, physiology, genetics, proteomics, molecular biology, and saliva among others. In 2003, we published our first review (Soares & Turco 2003) on this vector covering several aspects of Lu. longipalpis. This current review summarizes what has been published between 2003-2020. During this period, modern approaches were incorporated following the development of more advanced and sensitive techniques to assess this sand fly.

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Antissaliva Antibodies of Lutzomyia Longipalpis in area of Visceral Leishmaniasis

Cited by 4 publications

References 11 publications

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

Leishmania infection in blood donors: A new challenge in leishmaniasis transmission?

Presence of anti-Leishmania antibodies in candidates for kidney transplantation

Lutzomyia longipalpis: an update on this sand fly vector

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