Antisperm Antibodies in Prepubertal Boys With Cryptorchidism

Domagala, Alina; Havryluk, A.; Kamieniczna, Marzena; Chopyak, Valentyna; Kurpisz, Maciej

doi:10.1080/01485010600822747

Cited by 11 publications

(8 citation statements)

References 12 publications

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“…The precise mechanisms accounting for this clinical phenomenon are surrounded by controversies. ASA has been proposed to act as an active participator in the pathogenesis of cryptorchidism-associated infertility [9,14]. However, the present study failed to prove a significant level of ASA in the infertile males with a history of cryptorchidism.…”

Section: Discussioncontrasting

confidence: 54%

“…However, data pertaining to the formation of ASA in cryptorchid males is conflicting. Several studies have revealed a high incidence of ASA in prepubertal boys with cryptorchidism [5,9]. ASA was even thought to emerge as an inherent characteristic in cryptorchids independent of their undescended testis location and orchidopexy treatment [10].…”

Section: Introductionmentioning

confidence: 99%

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Cryptorchidism Is Not a Risk Factor for Antisperm Antibody Production in Post-Orchidopexy Males with Infertility

Jiang

Zhu²

2013

Urol Int

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Introduction: Infertility in adulthood is a well-recognized consequence of cryptorchidism, even after successful orchidopexy. Autoimmune reactions against spermatozoa are associated with infertility and often found in cryptorchids. The purposes of this study were to evaluate the linkage between antisperm antibody (ASA) and cryptorchidism, and furthermore, to clarify whether ASA is involved in cryptorchidism-associated infertility. Materials and Methods: We investigated a total of 48 infertile males with a history of unilateral (n = 30) or bilateral (n = 18) cryptorchidism who had undergone successful orchidopexy in prepuberty, and 20 age-matched fertile and healthy males were collected as controls. ASA in sperm samples was detected by the direct immunobead test, and semen analysis was performed concomitantly. Results: No infertile case satisfied the diagnostic criteria of ASA-mediated infertility set forth by the World Health Organization. Decreases in both sperm concentration and motility accompanied by increases in abnormal morphology were seen in infertile cryptorchids when compared with the healthy controls. Conclusions: Testicular heat exposure in prepuberty is not a risk factor for ASA production. It is evident that the mechanisms that underlie cryptorchidism-associated infertility do not involve ASA. Poor sperm characteristics in cryptorchids resulting from thermal damage to the testes seem to be responsible for their infertility, even after successful orchidopexy.

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Section: Discussioncontrasting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Cryptorchidism Is Not a Risk Factor for Antisperm Antibody Production in Post-Orchidopexy Males with Infertility

Jiang

Zhu²

2013

Urol Int

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“…Indeed, there are differences in the literature in ASA measurements intended to clarify the role of autoimmunity in the likely cause of sub‐/infertility in children with UDT. For instance, the reported ASA positivity range was 25% of boys who underwent orchidopexy, 18 13.8% of boys with UDT, 19 and 3.95% of prepubertal boys with UDT 17 . In our study, ASA was determined at a level of 20.5% in the UDT group and 13.6% in healthy individuals.…”

Section: Discussionsupporting

confidence: 41%

“…They have been found in the blood and seminal fluid of men with UDT. However, the presence of ASA as such in sexually immature boys remains a controversial issue 5,17 . Indeed, there are differences in the literature in ASA measurements intended to clarify the role of autoimmunity in the likely cause of sub‐/infertility in children with UDT.…”

Section: Discussionmentioning

confidence: 99%

Oxidative, inflammatory and immunologic status in children with undescended testes

İmamoğlu¹,

Bülbül²,

Kaklıkkaya

et al. 2012

Pediatrics International

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“…Nevertheless, anti-sperm antibodies (AsA) in serum samples from prepubertal boys were reported [7,8], and our earlier findings showed that cryptorchidism may play an important role in antibody formation at this age [9-11]. The human major histocompatibility complex Class II HLA molecules, by presenting antigens to helper T cells, play a decisive role in induction of antibody production [12].…”

Section: Introductionmentioning

confidence: 99%

Weak association of anti-sperm antibodies and strong association of familial cryptorchidism/infertility with HLA-DRB1polymorphisms in prepubertal Ukrainian boys

Kurpisz

Nakonechnyy

Niepiekło-Miniewska

et al. 2011

Reprod Biol Endocrinol

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BackgroundCryptorchidism is a frequent syndrome occurring in 1-2% of males within the first year of age. Autoimmune reactions, particularly directed to testicular elements and/or spermatozoa have been found to be often associated with cryptorchidism. Therefore we investigated in this study the frequency of HLA class II alleles in order to recognize possible genetic predisposition for antisperm antibodies development in prepubertal boys with diagnosed cryptorchidism in Caucasoid population.MethodsSixty prepubertal boys with cryptorchidism and sixty healthy boys were examined for anti-sperm antibodies by indirect immunobead test as well as for their HLA-DRB1 and -DQB1 alleles using DNA obtained from peripheral blood leukocytes. The typing of HLA-DRB1 and -DQB1 was performed by using PCR-SSP low resolution method.ResultsAllele frequencies of HLA-DRB1 and HLA-DQB1 did not differ between boys with cryptorchidism and control boys. However, weakly significant differences in DRB1*04 (p corrected = 0.0475) and DQB1*06 (p corrected = 0.0385) were seen between cryptorchid patients with and without AsA, but none of these two patient groups differed significantly in HLA class II frequencies from controls except for AsA-negatives and HLA-DQB1*06 (p corrected = 0.0247). On the other hand, comparison of cryptorchid boys with familial cryptorchidism and/or infertility to control boys revealed highly significant (p corrected = 0.0006) difference in HLA-DRB*11 frequency, whereas boys with sporadic cryptorchidism did not differ from control. A much weaker, but still significant difference in DRB*11 frequency was also observed between boys with bilateral cryptorchidism and controls (p corrected = 0.037), whereas patients with unilateral cryptorchidism were not different from control in frequency of any HLA-DRB1 or -DQB1 allele tested.ConclusionsPredisposition to produce anti-sperm antibodies seems to be only weakly associated with HLA class II genes, although this question requires further study on much larger population sample. It is plausible that familial and sporadic cryptorchidism may present distinct genetic background. The same may, to lower extent, apply to bilateral and unilateral cryptorchidism.

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Antisperm Antibodies in Prepubertal Boys With Cryptorchidism

Cited by 11 publications

References 12 publications

Cryptorchidism Is Not a Risk Factor for Antisperm Antibody Production in Post-Orchidopexy Males with Infertility

Cryptorchidism Is Not a Risk Factor for Antisperm Antibody Production in Post-Orchidopexy Males with Infertility

Oxidative, inflammatory and immunologic status in children with undescended testes

Weak association of anti-sperm antibodies and strong association of familial cryptorchidism/infertility with HLA-DRB1polymorphisms in prepubertal Ukrainian boys

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