Oxidative, inflammatory and immunologic status in children with undescended testes

İmamoğlu, Mustafa; Bülbül, Serap Samut; Kaklıkkaya, Neşe; Sarıhan, Haluk

doi:10.1111/j.1442-200x.2012.03695.x

Cited by 27 publications

(22 citation statements)

References 18 publications

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“…The most susceptible response to testicular inflammation is the inhibition of spermatogenesis, by damaging the seminiferous epithelium and promoting the apoptosis of spermatogenic cells in the reproductive system. Moreover, inflammation is also associated with oxidative stress which impairs sperm function [43]. This crosstalk between inflammation and spermatogenesis is evidenced by the current histological results.…”

Section: Discussionmentioning

confidence: 56%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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Section: Discussionmentioning

confidence: 56%

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Ramadan¹,

Schaalan²,

Mahmoud³

2018

J Steroids Horm Sci

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“…The elevation and/or reduction in antioxidant defence systems accompanied by a concomitant increase in MDA concentration highlights the induction of oxidative stress (Abarikwu, Njoku, et al., ; Imamoğlu, Bülbül, Kaklikkaya, & Sarihan, ). More so, the increase in the activities or levels of antioxidant defence in experimental models is seen as an adaptive response to oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…() and could be attributed to peroxidative stress in testicular tissues induced by phytochemicals present in the plant (Hur & Gray, ; Iwalewa et al., ; Saalu et al., ). Spermatogenic process is vulnerable to testicular inflammation, which results in erosion of seminiferous epithelium and increased loss of spermatogenic cells (Imamoğlu et al, ). Thus, we also evaluated serum myeloperoxidase (MPO) activity, an enzyme discharged during inflammation and testicular damage (De Freitas et al., ).…”

Section: Discussionmentioning

confidence: 99%

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

2018

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The growing patronage on herbal remedies and formulations from natural products in most developing countries has warranted research into certain health challenges including their antifertility effects. This study assessed the effects of boiled Telfairia occidentalis (TO) seed-supplemented diets on the level of testosterone and semen quality in Wistar rats. Boiled TO seed diets at 10%, 15% and 30% were given to rats for 60 days. Our study showed that sperm quality was impaired as evidenced by the decreased number of motile spermatozoa, epididymal sperm numbers, percentage live/dead ratio and increased numbers of abnormal spermatozoa comparable to control values (p < .05). Feeding of rats with 10% and 15% TO seed-supplemented diets increased testosterone levels nonsignificantly, while in the 30% TO seed diet animals, the level of serum testosterone was found to decrease significantly compared to control values. Furthermore, TO diet caused a nonsignificant increase in the activity of superoxide dismutase and the concentrations of reduced glutathione and malondialdehyde except for the significant increase in malondialdehyde level in the testes of the 10% TO diet group. A nonsignificant decrease in myeloperoxidase activity was also observed in the 10% and 15% but not 30% TO diet group. Histological damages characterised by severe loss of germ cells were more pronounced in the 10% TO diet group. Fourier transform infrared spectroscopy analysis of boiled TO seeds revealed the presence of esters, alkenes, hydroxyl and alcohol functional groups. Thus, boiled TO seed-supplemented diet evoked antifertility effects in rats, and the effects on the toxicity end points investigated were not dose-dependent.

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“…This may be caused by the higher temperature present in the inguinal canal, which upregulates reactive oxygen species (ROS) levels in cryptorchid testes; this may favour germ cell apoptosis and a reduction in testis weight (Imamo glu et al, 2012;Liu et al, 2012). Moreover, all studied boys were prepubertal.…”

Section: Discussionmentioning

confidence: 99%

“…The initial median volume of the unilateral undescended testis before treatment was significantly lower in all examined groups (median TAI 13-33.4%). This may be caused by the higher temperature present in the inguinal canal, which upregulates reactive oxygen species (ROS) levels in cryptorchid testes; this may favour germ cell apoptosis and a reduction in testis weight (Imamo glu et al, 2012;Liu et al, 2012). Moreover, 32.2 (0-86) 13.0 (0-72) 33.4 (1.5-80.0) 1 vs. 2; p = 0.0002 2 vs. 3; p = 0.0002 TV (mL) affected testis 9-12 mo.…”

Section: Discussionmentioning

confidence: 99%

The volume of unilaterally undescended testis afterhCGtherapy compared to orchidopexy and combined methods

2018

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The aim of the study was to compare the effects of human chorionic gonadotropin (hCG) therapy with those of surgical or combined therapy on testicular volume (TV) in boys at different ages with unilateral canalicular undescended testis (UDT). In total, 155 boys aged 1 to 12 years were treated: either surgically (ST), or by 50 IU/kg body weight hCG administration every three days for five weeks (HT), or by a combination of the two. The patients underwent ultrasound examination of TV before the treatment, 9-12 (median 10) and 24-39 months (median 32) after therapy. The testicular atrophy index (TAI) of the affected testicle was calculated. The success rate was 94.7% for ST, 39.2% for HT and 98% for HST patients. The atrophy rate was 5.3% for ST, 0% for HT and 2% for HST. Neither treatment type nor patient age significantly influenced gonadal atrophy. No significant differences in TV of the affected testis were observed after treatment between the groups. The TAI values were significantly the lowest in HT group (p = 0.0006). Both TV and TAI changes from the baseline values did not differ between the treatment groups. At the 24- to 39-month follow-up, no significant differences were observed in the change in baseline TV and baseline TAI between age groups. TV of the affected testis increased significantly (p = 0.0000), and TAI decreased significantly over time (p = 0.01), with no significant differences depending on the age group, treatment type or the interaction of the two factors. The hCG therapy did not impair the development of affected and healthy testes, neither as single nor as neoadjuvant therapy, both during early assessment and after 2-3 years. Patients' age at the initiation of treatment seems irrelevant.

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Oxidative, inflammatory and immunologic status in children with undescended testes

Abstract: The results indicate that children with UDT are exposed to high levels of oxidative stress and inflammatory reaction. This could negatively affect the future fertility in these children.

Cited by 27 publications

References 18 publications

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Protective Effect of Taurine on Thiopurine-Induced Testicular Atrophy in Male Albino Rats

Telfairia occidentalis-supplemented diet induces changes in sperm parameters and testosterone level in rats

The volume of unilaterally undescended testis afterhCGtherapy compared to orchidopexy and combined methods

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