Antispasmodic ortho-Substituted Phenoxyalkylamines

Crystal structure of (4-ethoxynaphthalen-1-yl)(furan-2-yl)methanone, C17H14O3

“…Diaryl ketones are important building blocks in the fields of medicinal, pharmaceutical and agricultural chemistry [4]. Their derivatives have been used as selective inhibitors of human immunodeficiency virus type 1 reverse transcriptase [5], antispasmodic agents [6], inhibitors of transforming growth factor-kinase [7]. Great efforts have been devoted to synthesis of the attractive target diaryl ketones skeleton due to its prevalent biological activity [8].…”

Nickel-Catalyzed Decarbonyloxidation of 3-Aryl Benzofuran-2(3H)-ones to 2-Hydroxybenzophenones

“…Owing to their high reactivity, 2-hydroxybenzophenones are important building blocks in organic synthesis for medicinal chemicals . The derivatives with the 2-hydroxybenzophenone skeleton exhibit a variety of biological activities.…”

Rhodium‐Catalyzed Directing‐Group‐Assisted Aldehydic C–H Arylations with Aryl Halides

“…Molecular scaffolds such as 2‐hydroxybenzophenones present in natural products, are associated with immense biological properties, Some of these skeletons are shown in Figure , of which hydroxyphenstatin ( 1 ) exhibits potent cytotoxicity and inhibits tubulin polymerization. [4b] Similarly, 1,5‐dimethoxyajacareubin ( 2 ) extracted from the stem bark of Garcinia buchananii has strong antioxidative, oxygen‐radical absorbance capacity. [1b] Further, calanone ( 3 ) isolated from the bark of Calophyllum teysmannii var.…”

“…[2a] The alkoxybenzophenone 4 is known as antispasmodic agent. [4a] Additionally, morintrifolin A ( 5 ) isolated from the roots of M. citrifolia (noni) has been used in the treatment of asthma, bone fractures, cancer and other ailments. [2b] Some 2‐hydroxybenzophenones such as 6 – 9 have been used as UV absorbers in sunscreens…”