Antispasmodic Activity of β-Damascenone and<i>E</i>-Phytol Isolated from<i>Ipomoea pes-caprae</i>

Pongprayoon, U.; Bæckström, Peter; Jacobsson, Ulla; Lindström, Mikael; Bohlin, Lars

doi:10.1055/s-2006-961381

Cited by 72 publications

(67 citation statements)

References 7 publications

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“…Bioassay guided fractionation of this extract resulted in isolation of the isoprenoids E-phytol and β-damascenone. The antispasmodic potencies of these compounds were found to be in the same range as that of papaverine, a known spasmolytic agent (Pongprayoon et al, 1992a). However, similar study with the plant collected in Brazil showed differece in terms of the chemical composition and did not showed antispasmodic activity when tested on isolated guineapig ileum and rat duodenum (Emendorfer et al, 2005).…”

Section: Ipomoea Parasitica (Kunth) G Donmentioning

confidence: 93%

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

168

120

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Approximately 600-700 species of Ipomoea, Convolvulaceae, are found throughout tropical and subtropical regions of the world. Several of those species have been used as ornamental plants, food, medicines or in religious ritual. The present work reviews the traditional uses, chemistry and biological activities of Ipomoea species and illustrates the potential of the genus as a source of therapeutic agents. These species are used in different parts of the world for the treatment of several diseases, such as, diabetes, hypertension, dysentery, constipation, fatigue, arthritis, rheumatism, hydrocephaly, meningitis, kidney ailments and infl ammations. Some of these species showed antimicrobial, analgesic, spasmolitic, spasmogenic, hypoglycemic, hypotensive, anticoagulant, anti-infl ammatory, psychotomimetic and anticancer activities. Alkaloids, phenolics compounds and glycolipids are the most common biologically active constituents from these plant extracts.

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Section: Ipomoea Parasitica (Kunth) G Donmentioning

confidence: 93%

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Meira¹,

Silva²,

David³

et al. 2012

Rev. bras. farmacogn.

168

120

View full text Add to dashboard Cite

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“…Since endothelial cell contraction increases vascular permeability, and since this permeability is inhibited by vasodilating agents, the antispasmodic activity of I. pescaprae can be assumed to contribute to the anti-inflammatory action of this plant (6). The cited investigators based their hypo-thesis on the tentative theory that endothelial cell contraction causes increased vascular permeability and on the fact that agents such as ß-adrenoceptor agonists and calcium antagonists inhibit this permeability with general relaxant properties.…”

Section: Discussionmentioning

confidence: 99%

“…A clinical study has reported an analgesic effect of this extract (5). In addition, other species of the family Convolvulaceae such as I. pes-caprae also have been reported to have anti-inflammatory, antispasmodic and antihemolytic properties (6).…”

Section: Introductionmentioning

confidence: 91%

Anti-inflammatory and antispasmodic activity of Ipomoea imperati (Vahl) Griseb (Convolvulaceae)

Paula

Hayashi

Freitas

2003

Braz J Med Biol Res

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Ipomoea imperati (Convolvulaceae) lives on the sandy shores of the Brazilian coast and in other areas of the world. The anti-inflammatory activity of a methanol-water extract of the leaves of I. imperati was investigated in experimental models of acute and subchronic inflammation. Topical application of the extract (10 mg/ear) inhibited mouse ear edema induced by croton oil (89.0 ± 1.3% by the lipid fraction with an IC 50 of 3.97 mg/ear and 57.0 ± 1.3% by the aqueous fraction with an IC 50 of 3.5 mg/ear) and arachidonic acid (42.0 ± 2.0% with an IC 50 of 4.98 mg/ear and 31.0 ± 2.0% with an IC 50 of 4.72 mg/ear). Phospholipase A 2 , purified from Apis mellifera bee venom, was also inhibited by the extract (5.0 mg/ml lipid and aqueous fraction) in vitro in a dose-dependent manner (85% by the lipid fraction with an IC 50 of 3.22 mg/ml and 25% by the aqueous fraction with an IC 50 of 3.43 mg/ ml). The methanol-water extract of I. imperati (1000 mg/kg) administered by the oral route also inhibited the formation of cotton pelletinduced granulomas (73.2 ± 1.2% by the lipid fraction and 56.14 ± 2.7% by the aqueous fraction) and did not cause gastric mucosal lesions. I. imperati extracts (10 mg/ml) also inhibited in a dosedependent manner the muscle contractions of guinea pig ileum induced by acetylcholine and histamine (IC 50 of 1.60 mg/ml for the lipid fraction and 4.12 mg/ml for the aqueous fraction). These results suggest the use of I. imperati as an anti-inflammatory and antispasmodic agent in traditional medicine. Correspondence

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“…This plant stabilized sand dunes and prevented coastal erosion (Hill, 2001) and used in folk remedies for different types of ailments (Ganjir et al, 2013). Pharmacological profiling of the plant showed the following activities: antioxidant (Ramanathan et al, 2012;Parekh et al, 2012), analgesic (De Souza et al, 2000;Bragadeeswaran et al, 2010;Rajamoni, 2010;Vieira et al, 2012), anti-inflammatory (Vieira et al, 2012;Venkataraman et al, 2013a;Pongprayoon et al, 2006), antispasmodic (Pongprayoon et al, 1992), antinociceptive (Vieira et al, 2012;Krogh et al, 1999;De Souza et al, 2000), antiarthritic (Venkataraman et al, 2013b), antihistaminic (Wasuwat, 1970), insulinogenic and hypoglycemic activities (Khan et al, 1994), antifungal -Candida albicans and Microsporum audouinni (Ramanathan et al, 2011) and immunostimulatory (Philippi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…This area has a warm humid temperate climate with hot summers and no dry season (Weather Spark beta, 2012). Conversely, Pongprayoon et al (1992) in Sweden, had isolated antispasmodically acting isoprenoids betadamascenone and E-phyto. Most parts of Sweden are icebound in winter, but experience elevated temperature ranging from 13 0 C to 17 0 C in the month of July (WeatherOnline, 2013).…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening and Antioxidative Potentials of “Beach Morning Glory” Ipomoea pes- caprae (Linn.) Roth Leaves Extract

Matunog

Bajo

2013

JMDS

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Ipomoea pes-caprae (Linn.) Roth, or beach morning glory, is a mangrove associate medicinal plant species of Convolvulaceae family that favorably grows in tropical and subtropical countries. Previous phytochemical screening revealed the presence of pharmacologically active components which could differ according to environmental conditions. In the Philippines, evidences on extensive investigation of the plant are not yet available. This study aimed to conduct phytochemical screening, and antioxidative potential determination of the dried leaves aqueous ethanol extract of I. pes-caprae (Linn.) Roth. Exhaustive serial extraction apportioned the crude ethanol extract (CEE) into hexane extract (HE); ethyl acetate extract (EAE); methanol extract (ME) and aqueous extract (AE). Ferric thiocyanate (FTC) assay determined the antioxidative potentials of CEE and the four serial extracts. The positive controls used in FTC assay were Vitamin E and butylated hydroxyl toluene (BHT). Phytochemical screening of CEE showed the presence of alkaloids; flavonoids; steroids and triterpenes; and tannins and phenolic compounds. FTC assay on CEE showed antioxidative activity but of lower extent than vitamin E and BHT. For serial extracts, FTC assay revealed that ME and AE possessed antioxidative activity comparable to vitamin E and BHT. These results showed that the wildly grown I. pescaprae is a potential source of pharmacologically active phytochemicals specifically the antioxidants.

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Antispasmodic Activity of β-Damascenone andE-Phytol Isolated fromIpomoea pes-caprae

Cited by 72 publications

References 7 publications

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Review of the genus Ipomoea: traditional uses, chemistry and biological activities

Anti-inflammatory and antispasmodic activity of Ipomoea imperati (Vahl) Griseb (Convolvulaceae)

Phytochemical Screening and Antioxidative Potentials of “Beach Morning Glory” Ipomoea pes- caprae (Linn.) Roth Leaves Extract

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