Antiseptic properties of two calix[4]arenes derivatives on the human coronavirus 229E

Geller, Chloé; Fontanay, Stéphane; Mourer, Maxime; Dibama, Hugues Massimba; Regnouf‐de‐Vains, Jean‐Bernard; Finance, C.; Duval, Raphaël E.

doi:10.1016/j.antiviral.2010.09.009

Cited by 18 publications

(16 citation statements)

References 21 publications

(23 reference statements)

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“…Two other studies conducted in our laboratory concerned the HCoV 229E and its sensitivity to two widely used antiseptics, chlorhexidine and hexamidine, but also to new molecules belonging to the calixarene family [130,131]. In these studies, antiseptic antiviral activities were assayed thanks to suspension tests and the efficacy criterion was a reduction of 4 log 10 , as recommended by the European Standard [122].…”

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

“…It was then not sufficient to claim an antiseptic anti-HCoV 229E activity. Hexamidine did not show any activity against HCoV 229E [130,131]. These results highlighted the necessity of (i) evaluating the activity of commonly used antiseptics-disinfectants against different viruses, to be sure of their efficiency and to develop a targeted antisepsis, and (ii) developing new active noncytotoxic molecules.…”

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

“…the tetra-para-sulfonato-calix[4]arene (C[4]S) and the 1,3-bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene (C[4]S-BTZ) [130,131]. These molecules were attractive targets at first because they did not show any cytotoxicity.…”

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

“…Evaluation of antiseptic HCoV 229E activity of (a) chlorhexidine (CHX) and (b) the 1,3-bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene (C[4]S-BTZ) [130,131]. …”

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

See 3 more Smart Citations

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

Geller

Varbanov

Duval

2012

Viruses

387

374

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The Coronaviridae family, an enveloped RNA virus family, and, more particularly, human coronaviruses (HCoV), were historically known to be responsible for a large portion of common colds and other upper respiratory tract infections. HCoV are now known to be involved in more serious respiratory diseases, i.e. bronchitis, bronchiolitis or pneumonia, especially in young children and neonates, elderly people and immunosuppressed patients. They have also been involved in nosocomial viral infections. In 2002–2003, the outbreak of severe acute respiratory syndrome (SARS), due to a newly discovered coronavirus, the SARS-associated coronavirus (SARS-CoV); led to a new awareness of the medical importance of the Coronaviridae family. This pathogen, responsible for an emerging disease in humans, with high risk of fatal outcome; underline the pressing need for new approaches to the management of the infection, and primarily to its prevention. Another interesting feature of coronaviruses is their potential environmental resistance, despite the accepted fragility of enveloped viruses. Indeed, several studies have described the ability of HCoVs (i.e. HCoV 229E, HCoV OC43 (also known as betacoronavirus 1), NL63, HKU1 or SARS-CoV) to survive in different environmental conditions (e.g. temperature and humidity), on different supports found in hospital settings such as aluminum, sterile sponges or latex surgical gloves or in biological fluids. Finally, taking into account the persisting lack of specific antiviral treatments (there is, in fact, no specific treatment available to fight coronaviruses infections), the Coronaviridae specificities (i.e. pathogenicity, potential environmental resistance) make them a challenging model for the development of efficient means of prevention, as an adapted antisepsis-disinfection, to prevent the environmental spread of such infective agents. This review will summarize current knowledge on the capacity of human coronaviruses to survive in the environment and the efficacy of well-known antiseptic-disinfectants against them, with particular focus on the development of new methodologies to evaluate the activity of new antiseptic-disinfectants on viruses.

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Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

“…Evaluation of antiseptic HCoV 229E activity of (a) chlorhexidine (CHX) and (b) the 1,3-bis(bithiazolyl)-tetra-para-sulfonato-calix[4]arene (C[4]S-BTZ) [130,131]. …”

Section: Antisepsis-disinfection: An Efficient Weapon With Room Fmentioning

confidence: 99%

See 2 more Smart Citations

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

Geller

Varbanov

Duval

2012

Viruses

387

374

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“…17 Biological studies related to plasmid DNA binding and cell transfection have been recently reported by Ungaro and co-workers. 20 In this field, our contribution has been devoted to the design of new anti-HIV 21 or anti-corona virus 22 agents and, with regards to spreading resistances of pathogenic microorganisms against actual antibiotics, 23 antibacterial 24-30 agents. Calixarene-based mimics of vancomycin has also been described.…”

Section: Introductionmentioning

confidence: 99%

Molecular drug-organiser: Synthesis, characterization and biological evaluation of penicillin V and/or nalidixic acid calixarene-based podands

Salem

Sautrey²,

Fontanay³

et al. 2011

Bioorganic & Medicinal Chemistry

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Two well-known antibiotic heterocycles, the 'quinolone' nalidixic acid and the β-lactam penicillin V, active at different levels of the bacterial growth process, have been attached via an ether-ester junction to the p-tert-butylcalix[4]arene lower rim, in alternate position. The resulting hydrophobic molecular drug-organisers were fully characterized, and evaluated over two Gram negative and three Gram positive reference strains, using disk diffusion assays with disks impregnated with solution of title compound in pure DMSO. An interesting activity was observed over Staphylococcus aureus ATCC 25923 with the dis-symmetrical podand incorporating one penicillin and one nalidixic ester moieties.

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Physicochemical susceptibility of SARS‐CoV‐2 to disinfection and physical approach of prophylaxis

Saadatpour

Mohammadipanah

2020

Health Science Reports

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The transmission control of the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the most effective strategy by the absence of its specified vaccine or drug. Although the aerosol mediated transmission of SARS‐CoV‐2 has been confirmed, the physicochemical treatment of the biotic and abiotic objects is still the most promising approach in its infection control. The front line of the most effective disinfecting compounds on SARS‐CoV‐2 implies to be sodium hypochlorite, ethanol, hydrogen peroxide, quaternary ammonium compounds, and phenolic compounds, respectively. However, widely used compounds of alkyldimethylbenzylammonium chloride (benzalkonium chloride) biguanides (chlorhexidine) have not shown the multitude load reduction in less than 10 minutes. The susceptibility of SARS‐CoV‐2 to physical treatment follows the pattern of heat, acidity, and UV radiation. Rather all of the mentioned physical or chemical treatments, target the envelope proteins of the coronavirus mainly by impairing its entry to host cells. The anti‐SARS‐CoV‐2 activity of combinatorial physicochemical treatments or evaluation of new chemical entities or physical treatments such as microwave irradiation still needs to be explored. Therefore, the development of a reliable decontamination protocol for SARS‐CoV‐2 demands revealing its stability pattern study vs a spectrum of single and combinatorial physicochemical parameters.

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Antiseptic properties of two calix[4]arenes derivatives on the human coronavirus 229E

Cited by 18 publications

References 21 publications

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

Human Coronaviruses: Insights into Environmental Resistance and Its Influence on the Development of New Antiseptic Strategies

Molecular drug-organiser: Synthesis, characterization and biological evaluation of penicillin V and/or nalidixic acid calixarene-based podands

Physicochemical susceptibility of SARS‐CoV‐2 to disinfection and physical approach of prophylaxis

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