Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2

Polymeric surfactants are a special class of the polymers that have amphiphilic characteristics of surfactants. In selective solvents, polymeric surfactants exhibit interesting association processes and develop self‐assembled structures. Their capacity to create micellar aggregates with stimuli‐responsive behavior in aqueous solutions, enables the creation of smart materials for many applications. The only restrictions to the creation of polymeric surfactants with complicated structures using current synthetic methods are the researchers' interests and creativity. The chemical structure of the polymer and its aqueous solution characteristics (viscosity and surface tension) should be demonstrated as having a distinct and commonly accepted connection. Unavailability of systematic and updated review on these important molecules demands a comprehensive compilation and consistent discussion on key physical aspects, characterization, synthetic techniques, and their useful applications like enhanced recovery of oil, antimicrobial potential, water treatment, pharmaceutical, etc.

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“…However, their high costs over conventional lowmolecular weight surfactants are still a challenge. [162][163][164][165][166][167][168][169]…”

Section: Limitations and Future Prospectsmentioning

confidence: 99%

Polymeric Surfactants: Recent Advancement in Their Synthesis, Properties, and Industrial Applications

Aleid

Tripathy

Gupta

et al. 2023

Macro Chemistry & Physics

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“…Hydrogels are used in sanitary products such as diapers [ 23 , 24 ], because of their highly absorbent properties, and in the pharmaceutical industry as superdisintegrants [ 25 ]. Since the COVID-19 pandemic, hydrogels have also been in particular demand as carriers for disinfectant molecules, allowing them to be used to implement antiseptic coatings with a long-lasting effect against COVID-19 in hospitals [ 26 ]. Another popular application area is the biomedical field.…”

Section: Hydrogelsmentioning

confidence: 99%

A Review on Novel Channel Materials for Particle Image Velocimetry Measurements—Usability of Hydrogels in Cardiovascular Applications

Winkler

Kuhn

Hentschel

et al. 2022

Gels

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Particle image velocimetry (PIV) is an optical and contactless measurement method for analyzing fluid blood dynamics in cardiovascular research. The main challenge to visualization investigated in the current research was matching the channel material’s index of refraction (IOR) to that of the fluid. Silicone is typically used as a channel material for these applications, so optical matching cannot be proven. This review considers hydrogel as a new PIV channel material for IOR matching. The advantages of hydrogels are their optical and mechanical properties. Hydrogels swell more than 90 vol% when hydrated in an aqueous solution and have an elastic behavior. This paper aimed to review single, double, and triple networks and nanocomposite hydrogels with suitable optical and mechanical properties to be used as PIV channel material, with a focus on cardiovascular applications. The properties are summarized in seven hydrogel groups: PAMPS, PAA, PVA, PAAm, PEG and PEO, PSA, and PNIPA. The reliability of the optical properties is related to low IORs, which allow higher light transmission. On the other hand, elastic modulus, tensile/compressive stress, and nominal tensile/compressive strain are higher for multiple-cross-linked and nanocomposite hydrogels than single mono-cross-linked gels. This review describes methods for measuring optical and mechanical properties, e.g., refractometry and mechanical testing.

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“…Self-organization in polyelectrolyte-surfactant solutions causes the formation of functional nanoscale systems [2,6], which are used in nanotechnology [7,8] and medicine [4,9]. Polyelectrolyte-surfactant complexes are demanded for template synthesis of materials [10,11], target drug delivery systems [4,7,12,13], and fabrication of soft matter with smart stimuli-responsive capabilities [5,14].…”

Section: Introductionmentioning

confidence: 99%

Tuning Properties of Polyelectrolyte-Surfactant Associates in Two-Phase Microfluidic Flows

Bezrukov

Galyametdinov

2022

Polymers

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This work focuses on identifying and prioritizing factors that allow control of the properties of polyelectrolyte-surfactant complexes in two-phase microfluidic confinement and provide advantages over synthesis of such complexes in macroscopic conditions. We characterize the impact of polymer and surfactant aqueous flow conditions on the formation of microscale droplets and fluid threads in the presence of an immiscible organic solvent. We perform an experimental and selected numerical analysis of fast supramolecular reactions in droplets and threads. The work offers a quantitative control over properties of polyelectrolyte-surfactant complexes produced in two-phase confinement by varying capillary numbers and the ratio of aqueous and organic flowrates. We propose a combined thread-droplet mode to synthesize polyelectrolyte-surfactant complexes. This mode allows the production of complexes in a broader size range of R ≈ 70–200 nm, as compared with synthesis in macroscopic conditions and the respective sizes R ≈ 100–120 nm. Due to a minimized impact of undesirable post-chip reactions and ordered microfluidic confinement conditions, the dispersity of microfluidic aggregates (PDI = 0.2–0.25) is lower than that of their analogs synthesized in bulk (PDI = 0.3–0.4). The proposed approach can be used for tailored synthesis of target drug delivery polyelectrolyte-surfactant systems in lab-on-chip devices for biomedical applications.

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Antiseptic Polymer–Surfactant Complexes with Long-Lasting Activity against SARS-CoV-2

Cited by 6 publications

References 76 publications

Polymeric Surfactants: Recent Advancement in Their Synthesis, Properties, and Industrial Applications

Polymeric Surfactants: Recent Advancement in Their Synthesis, Properties, and Industrial Applications

A Review on Novel Channel Materials for Particle Image Velocimetry Measurements—Usability of Hydrogels in Cardiovascular Applications

Tuning Properties of Polyelectrolyte-Surfactant Associates in Two-Phase Microfluidic Flows

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