Antisense Oligodeoxynucleotides as a Tool for Studying Cell Regulation: Mechanism of Uptake and Application to the Study of Oncogene Function

Neckers, Leonard Μ.

doi:10.1007/978-1-349-10869-5_11

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Therapeutics1

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1991

2000

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Cited by 6 publications

(1 citation statement)

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“…The possibility of suppressing the expression of oncogenes by antisense oligonucleotides has been demonstrated in cell cultures (for review see Paoletti et al, 1988;Neckers et aL, 1989;Tidd, 1990). Naturally, corresponding reactive analogs would cause more efficient inhibition of gene functions.…”

Section: Therapeuticsmentioning

confidence: 99%

Reactive oligonucleotide derivatives as gene-targeted biologically active compounds and affinity probes

Knorre

Vlassov

1991

Genetica

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Development of efficient methods for synthesis of oligonucleotides and oligonucleotide analogs has opened up the possibility of designing a broad spectrum of affinity reagents for specific modification of nucleic acids and proteins. These affinity reagents are used for investigation of the topology of ribosomes and nucleic acid polymerases. Oligonucleotides and their analogs are already used for suppression of specific gene expression and for elucidation of the physiological role of their products. Oligonucleotide derivatives appear to offer considerable promise as potential gene-targeted drugs such as antivirals and specific inhibitors of oncogene expression.

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Section: Therapeuticsmentioning

confidence: 99%