Antisenescence Effect of REAC Biomodulation to Counteract the Evolution of Myelodysplastic Syndrome

Maioli, Margherita; Rinaldi, Salvatore; Cruciani, Sara; Nečas, Alois; Fontani, Vania; Corda, G; Santaniello, Sara; Rinaldi, Arianna; Barcessat, Arp; Necasova, A; Castagna, Alessandro; Filipejova, Z; Ventura, Carlo; Fozza, Claudio

doi:10.33549/physiolres.934903

Cited by 4 publications

(6 citation statements)

References 46 publications

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“…REAC technology has been successfully applied in various medical fields, including pain management [ 26 , 68 , 69 ], depression, anxiety, and stress-related disorders [ 34 , 36 , 37 , 70 , 71 , 72 ], neurological disorders [ 35 , 73 , 74 , 75 , 76 ], orthopedics [ 77 , 78 , 79 , 80 ], wound healing [ 30 , 81 , 82 , 83 ] anti senescence [ 84 , 85 , 86 ] and regenerative medicine [ 31 , 32 , 79 , 87 , 88 , 89 ]. Clinical trials have demonstrated the safety and tolerability of REAC technology, with no significant adverse effects reported.…”

Section: Methodsmentioning

confidence: 99%

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

Silva,

Barcessat,

Gonçalves

et al. 2023

JPM

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Fibromyalgia syndrome (FS) is a disorder characterized by widespread musculoskeletal pain and psychopathological symptoms, often associated with central pain modulation failure and dysfunctional adaptive responses to environmental stress. The Radio Electric Asymmetric Conveyer (REAC) technology is a neuromodulation technology. The aim of this study was to evaluate the effects of some REAC treatments on psychomotor responses and quality of life in 37 patients with FS. Tests were conducted before and after a single session of Neuro Postural Optimization and after a cycle of 18 sessions of Neuro Psycho Physical Optimization (NPPO), using evaluation of the functional dysmetria (FD) phenomenon, Sitting and Standing (SS), Time Up and Go (TUG) tests for motor evaluation, Fibromyalgia Impact Questionnaire (FIQ) for quality of life. The data were statistically analyzed, and the results showed a statistically significant improvement in motor response and quality of life parameters, including pain, as well as reduced FD measures in all participants. The study concludes that the neurobiological balance established by the REAC therapeutic protocols NPO and NPPO improved the dysfunctional adaptive state caused by environmental and exposomal stress in FS patients, leading to an improvement in psychomotor responses and quality of life. The findings suggest that REAC treatments could be an effective approach for FS patients, reducing the excessive use of analgesic drugs and improving daily activities.

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Section: Methodsmentioning

confidence: 99%

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

Silva,

Barcessat,

Gonçalves

et al. 2023

JPM

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show abstract

“…However, various factors can disrupt this asymmetry, leading to compromised cellular functions, including genetic and epigenetic modifications [ 5 , 35 ]. The Radio Electric Asymmetric Conveyer (REAC) technology has been developed to restore the correct asymmetry of intracellular charges and progressively recover altered cellular functions, including negative epigenetic modifications [ 21 , 25 , 28 ].…”

Section: Methodsmentioning

confidence: 99%

“…We have previously demonstrated the ability of REAC TO-RGN endogenous bioelectric manipulation to reprogram other tumor cell lines, as PC12, derived from a pheochromocytoma of the rat adrenal medulla [ 21 ], and to counteract the evolution of myelodysplastic syndrome modulating bone marrow-derived stem cell senescence [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

Impact of REAC Regenerative Endogenous Bioelectrical Cell Reprogramming on MCF7 Breast Cancer Cells

Fontani

Cruciani

Santaniello

et al. 2023

JPM

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Human breast adenocarcinoma is a form of cancer which has the tendency to metastasize to other tissues, including bones, lungs, brain, and liver. Several chemotherapeutic drugs are used to treat breast tumors. Their combination is used to simultaneously target different mechanisms involved in cell replication. Radio electric asymmetric conveyer (REAC) technology is an innovative technology, used both in vitro and in vivo, to induce cell reprogramming and counteract senescence processes. Within this context, we treated MCF-7 cells with a regenerative (RGN) REAC treatment for a period ranging between 3 and 7 days. We then analyzed cell viability by trypan blue assays and gene and protein expression by real time-qPCR and confocal microscope, respectively. We also detected the levels of the main proteins involved in tumor progression, DKK1 and SFRP1, by ELISA and cell senescence by β-galactosidase tests. Our results showed the ability of REAC RGN to counteract MCF-7 proliferation, probably inducing autophagy via the upregulation of Beclin-1 and LC3-I, and the modulation of specific tumorigenic biomarkers, such as DKK1 and SPFR1. Our results could suggest the application of the REAC RGN in future in vivo experiments, as an aid for the therapeutic strategies usually applied for breast cancer treatment.

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“…In addition, the effects of REAC protocols seem to be beneficial for slowing down the processes of neurodegenerative diseases (32) and the aging process (6,(33)(34)(35)(36), which inextricably cause changes in motor control mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Effects of the radio electric asymmetric conveyer (REAC) on motor disorders: An integrative review

Machado

Brun

Manffra

2023

Front. Med. Technol.

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IntroductionThe radio electric asymmetric conveyer (REAC) is a technology that has the purpose of restoring the cellular polarity triggering the rebalancing of the endogenous bioelectric field, which considering the neurological dysfunctions, affects the neural communication mechanisms. The studies published so far show that the REAC neuromodulation technology has positive effects in treating these dysfunctions, with the principles of endogenous bioelectricity as a basis to achieve these effects.ObjectivesThis study aims to review the literature that explored the effects of REAC protocols on motor control and to identify which mechanisms would be involved.Materials and methodsThis integrative review considered studies that used REAC as a therapeutic intervention directed at human motor control and experimental research with animals that applied REAC to obtain effects related to motor behavior.ResultsTen articles were included, eight clinical and two experimental studies. The clinical studies used the neuro postural optimization (NPO) protocol in 473 patients, of which 53 were healthy subjects, 91 were Alzheimer's disease patients, 128 were patients with atypical swallowing, 12 subjects with neurological diseases, and 189 were without the specification of disease. The experimental studies used the antalgic neuromodulation and neurodegeneration protocols in animal models.ConclusionThe information integrated in this review made it possible to consider REAC technology a promising resource for treating motor control dysfunctions. It is possible to infer that the technology promotes functional optimization of neuronal circuits that may be related to more efficient strategies to perform motor tasks.

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Antisenescence Effect of REAC Biomodulation to Counteract the Evolution of Myelodysplastic Syndrome

Cited by 4 publications

References 46 publications

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

REAC Neurobiological Modulation as a Precision Medicine Treatment for Fibromyalgia

Impact of REAC Regenerative Endogenous Bioelectrical Cell Reprogramming on MCF7 Breast Cancer Cells

Effects of the radio electric asymmetric conveyer (REAC) on motor disorders: An integrative review

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