Antisecretory factor modulates GABAergic transmission in the rat hippocampus

Kim, Malin; Wasling, Pontus; Xiao, Min-Yi; Jennische, Eva; Lange, Stefan; Hanse, Eric

doi:10.1016/j.regpep.2005.01.018

Cited by 17 publications

(27 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…50–60 min after applying AF-16 to the hippocampal slice there was a decrease in the frequency of sIPSCs to 78 ± 7% ( p < 0.05, paired t -test) of the frequency obtained prior to the application, without a significant change in the averaged amplitude 95 ± 7% ( p = 0.52, paired t -test) of the sIPSCs ( n = 8) (Figure 1A). As described previously (Kim et al, 2005), the effect of AF-16 on GABAergic transmission developed slowly over more than 30 min. There was no run-down of phasic GABAergic signaling (in the presence of TTX) in control experiments (Figures 2C, D).…”

Section: Resultssupporting

confidence: 62%

“…We have previously shown, using extracellular field recordings, that AF-16 reduced evoked feed-forward GABAergic inhibition onto CA1 pyramidal neurons (Kim et al, 2005). In the present study, using whole-cell patch clamp recordings, we further examined the effect of AF-16 on GABAergic inhibition onto CA1 pyramidal neurons.…”

Section: Resultsmentioning

confidence: 95%

“…We have previously shown in vitro that AF-16 affects neuronal signaling in the brain (Kim et al, 2005). Specifically, application of AF-16 to acute rat hippocampal slices reduces GABAergic transmission onto CA1 pyramidal cells without affecting glutamatergic transmission.…”

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in CA1 stratum radiatum interneurons

Strandberg

Lindquist

Lange

et al. 2014

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

Tonic GABAergic inhibition regulates neuronal excitability and has been implicated to be involved in both neurological and psychiatric diseases. We have previously shown that the endogenous peptide antisecretory factor (AF) decreases phasic GABAergic inhibition onto pyramidal CA1 neurons. In the present study, using whole-cell patch-clamp recordings, we investigated the mechanisms behind this disinhibition of CA1 pyramidal neurons by AF. We found that application of AF to acute rat hippocampal slices resulted in a reduction of the frequency, but not of the amplitude, of spontaneous inhibitory postsynaptic currents (sIPSCs) in CA1 pyramidal neurons. Miniature inhibitory postsynaptic currents (mIPSCs), recorded in the presence of tetrodotoxin (TTX), were however not affected by AF, neither in CA1 pyramidal cells, nor in stratum radiatum interneurons. Instead, AF caused an increase of the tonic GABAA current in stratum radiatum interneurons, leaving the tonic GABAergic transmission in CA1 pyramidal cells unaffected. These results show that the endogenous peptide AF enhances tonic, but not phasic, GABAergic signaling in CA1 stratum radiatum interneurons, without affecting tonic GABAergic signaling in CA1 pyramidal neurons. We suggest that this increased tonic GABAergic signaling in GABAergic interneurons could be a mechanism for the AF-mediated disinhibition of pyramidal neurons.

show abstract

Section: Resultssupporting

confidence: 62%

Section: Resultsmentioning

confidence: 95%

See 1 more Smart Citation

The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in CA1 stratum radiatum interneurons

Strandberg

Lindquist

Lange

et al. 2014

Front. Cell. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The same effect was also observed in hippocampal slices from rats immunised with CT administration or fed a diet containing hydrothermally processed cereals. To explain the AF-mediated effect on GABA transmission, it was hypothesised that AF might decrease the post-synaptic response by an internalisation of GABA A receptors and subsequent degradation in the proteasome (38) . The enteric nervous system, enclosed in the wall of the gastrointestinal tract, regulates motility and fluid transport, mainly without conscious control (39) .…”

Section: Effects Of Antisecretory Factor On the Nervous Systemmentioning

confidence: 99%

Antisecretory factor as a potential health-promoting molecule in man and animals

2010

View full text Add to dashboard Cite

Antisecretory factor (AF) is a protein secreted in plasma and other tissue fluids in mammals with proven antisecretory and anti-inflammatory activity; its immunohistological distribution suggests a role in the immune system. The expression level and the distribution of AF protein are altered during an immunological response. Exposure to bacterial toxins induces secretion of AF in plasma, probably reflecting a natural defence mechanism to agents causing diarrhoea, thereby contributing to a favourable clinical outcome and disease termination. An increase of AF levels in plasma by dietary means, such as specially processed cereals (SPC), has been demonstrated in human subjects and animals. Administration of SPC to patients affected by inflammatory bowel disease, gastroenteritis and Ménière's disease relieved symptoms and improved quality of life. A recent study showed the positive effect of SPC diet supplementation on prevention of the effects of exposure to low levels of blast overpressure in rats, reducing the extent of intracranial pressure increase and cognitive function impairment. AF-rich egg yolk powder improved health status in children suffering acute and chronic diarrhoea, reducing the frequency and increasing the consistency of stools. This kind of functional food could be used for prophylaxis in populations exposed to a high risk of morbidity and mortality caused by diarrhoea and as a complementary therapy in patients affected by chronic intestinal inflammatory disease to improve well-being. In pig husbandry AF-inducing diets, owing to their antisecretory activity and anti-inflammatory action, are a suitable option as an alternative to antibiotic growth promoters to counteract post-weaning diarrhoea.

show abstract

“…The authors of that study concluded that presence of a large bowel does not influence the induced endogenous capability of AF. Furthermore, AF has been reported to be a neurotransmitter acting via g-amino butyric acid, which suggests that a possible acting pathway for AF may be the enteric nervous system [23]. SPCs are a product derived from cereals manufactured by a controlled hydrothermal process.…”

Section: Introductionmentioning

confidence: 99%

Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome

Pagoldh

Eriksson²,

Heimtun³

et al. 2008

European Journal of Gastroenterology & Hepatology

Self Cite

View full text Add to dashboard Cite

In this study, nonprocessed cereals seemed to be as effective as specially processed cereals in decreasing faecal volume in general and especially in ulcerative colitis patients (mainly operated with nonileostomy techniques). Our results indicate that use of supplementary cereals is safe for this group of patients, but should optimally include evaluation of the underlying diagnosis and the surgical method used.

show abstract

Antisecretory factor modulates GABAergic transmission in the rat hippocampus

Cited by 17 publications

References 43 publications

The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in CA1 stratum radiatum interneurons

The endogenous peptide antisecretory factor promotes tonic GABAergic signaling in CA1 stratum radiatum interneurons

Antisecretory factor as a potential health-promoting molecule in man and animals

Effects of a supplementary diet with specially processed cereals in patients with short bowel syndrome

Contact Info

Product

Resources

About