1961
DOI: 10.1016/0002-9343(61)90142-5
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Antirheumatic potency of chemically modified adrenocortical steroids

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1962
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Cited by 21 publications
(7 citation statements)
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“…The ratio of the concentrations of' cortisol required to inhibit hair follicles in cultured skin, 7·5 J1g/ml medium (Singh and Hardy 1975), and of flumethasone required to cause wool fibre shedding here, about 7 ng/ml plasma, is approximately 1000: 1, a proportion not markedly dissimilar to 700: 1 reported for the same two chemicals in the liver glycogen deposition assay (Fried 1960) or from 730: 1 in the granuloma inhibition assay in rats (Boland 1961).…”
Section: Discussionmentioning
confidence: 53%
“…The ratio of the concentrations of' cortisol required to inhibit hair follicles in cultured skin, 7·5 J1g/ml medium (Singh and Hardy 1975), and of flumethasone required to cause wool fibre shedding here, about 7 ng/ml plasma, is approximately 1000: 1, a proportion not markedly dissimilar to 700: 1 reported for the same two chemicals in the liver glycogen deposition assay (Fried 1960) or from 730: 1 in the granuloma inhibition assay in rats (Boland 1961).…”
Section: Discussionmentioning
confidence: 53%
“…They are often simply exchanged for each other in the dose ratio of 10:1, because a single tablet contains either 5 mg of prendnisolone or 0.5 mg of betamethasone as an equivalent dose. This equivalency, however, has been decided on the basis of very early reports (Silber, 1959;Tolksdorf, 1959;Boland, 1961;Roberts, 1962).…”
mentioning
confidence: 99%
“…This order of decreasing activity is closely related to that described by others (16, 17). Similarly, one may also correlate steroidal modifications such as the addition of A1, 6-methyl,6-fluoro, 9-fluoro, 6,9-difluoro, 16-methy1, and 16,17-acetonide to the increasing order of biological activity ( 5 , 16,18,19).…”
Section: Discussionmentioning
confidence: 99%