Modified Granuloma Pouch Procedure for the Evaluation of Topically Applied Anti-inflammatory Steroids

DiPasquale, G.; Rassaert, Charles L.; McDougall, Edward

doi:10.1002/jps.2600590230

Cited by 8 publications

(2 citation statements)

References 11 publications

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“…1970: Anti-inflammatory activity of topically applied hydrocortisone acetate, methylprednisolone acetate, betamethasone 17-valerate, triamcinolone 16,17-acetonide, betamethasone, and fluocinolone acetonide was tested in an air pouch model. It was concluded that the air pouch model served as an application area and was used for the evaluation of commercially available corticosteroids [22].…”

Section: : Based On the Observation That Two Concomitant Tumors Imentioning

confidence: 99%

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

Franco‐Molina¹,

Santana-Krímskaya²,

Rodríguez‐Padilla³

2019

Cell Culture

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The tumor microenvironment (TME) is composed of cancer, immune, and stromal cells that interact through cell-to-cell contact and a diverse milieu of cytokines, chemokines, growth factors, and proteases. Several reports have linked the presence of specific cell subtypes with tumor stages, prognosis, and patient survival. Understanding cancer cell behavior and their response to treatment within the tumor microenvironment is essential to prevent establishment, growth, and progression of tumors. Many synthetic and biological agents have been tested using cell-based assays, which do not provide reliable predictive capacity for drug candidate performance in vivo. In this chapter, we discuss about the benefits of an air pouch tumor model, in which tumor cells are inoculated inside an air pouch created on the back of the mouse. The air pouch cancer model serves as a confined/localized tumor microenvironment, where direct contact of drug candidates and tumor cells is guaranteed in a tumor microenvironment context. Therefore, the efficacy of the therapeutic agent can be accurately assessed in vivo.

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Section: : Based On the Observation That Two Concomitant Tumors Imentioning

confidence: 99%

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

Franco‐Molina¹,

Santana-Krímskaya²,

Rodríguez‐Padilla³

2019

Cell Culture

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“…Topical application of steroids is used for the treatment of various skin complaints such as eczema and contact dermatitis. The laboratory evaluation of the local anti-inflammatory activity of these compounds has involved models such as the granuloma pouch (Dipasquale, Rassaert & McDougall, 1970) or ear irritation induced by croton oil (Tonelli, Thibault & Ringler, 1965). There is a continuing search, however, for an additional model having a closer aetiological resemblance to human disease which might be even more predictive of a clinical response.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of contact sensitivity in the mouse by topical application of corticosteroids

EVANS,

HOSSACK,

THOMSON

1971

British J Pharmacology

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Summary Topical application of oxazolone to the ears of mice previously sensitized to this hapten resulted in a marked increase in ear weight 24 h later. Topical application of hydrocortisone, betamethasone 17‐valerate, fluocinolone acetonide or triamcinolone acetonide inhibited this response in a dose dependent manner. The free alcohols of the three fluorinated compounds were only weakly active. Activity in this model was truly local. Oral administration of hydrocortisone or fluocinolone acetonide at doses comparable to those used topically failed to inhibit the ear swelling. Some steroids with poor anti‐inflammatory properties had no significant effect.

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Extemporaneous Formulation Of Topical Corticosteroids

Caldwell¹

1970

JAMA

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Modified Granuloma Pouch Procedure for the Evaluation of Topically Applied Anti-inflammatory Steroids

Cited by 8 publications

References 11 publications

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

Air Pouch Model: An Alternative Method for Cancer Drug Discovery

Inhibition of contact sensitivity in the mouse by topical application of corticosteroids

Extemporaneous Formulation Of Topical Corticosteroids

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