Antiretroviral Therapy

Sellers, Christopher; Wohl, David A.

doi:10.1016/j.idc.2014.05.004

Cited by 7 publications

(5 citation statements)

References 67 publications

(66 reference statements)

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“…While various observational studies had been inconsistent in defining the optimal time to initiate ART, there was substantial evidence that early initiation of ART improved survival and delayed disease progression; a gateway to the "test and treat" strategy. 24 This contradicted a previous approach where the urgency to initiate ART was greatest for clients with lower CD4 cell counts in whom there was a high risk of opportunistic infections, and non-AIDS morbidity, and mortality.…”

Section: Discussionmentioning

confidence: 94%

Differential Self-Reported Determinants to Antiretroviral Therapy Adherence: Findings from Caregivers of Children Under Five Years Living with Human Immunodeficiency Virus Infection Attending Al-Sabah Hospital, South Sudan

Tong¹,

Atuhairwe²,

Taremwa³

2020

HIV

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This study explored the caregivers' self-reported determinants of antiretroviral therapy (ART) adherence among children under five years living with human immunodeficiency virus (HIV) infection attending Al-Sabah Hospital, South Sudan. Methods: A cross-sectional study of 126 caregivers of HIV-infected children under five years was conducted at Al-Sabah Hospital, South Sudan. Data were collected using an intervieweradministered questionnaire. The self-reported adherence was measured as a binary variable using binary logistic regression. Only variables that were significant at bivariate analysis were analyzed at multivariate level and interpreted using the odds ratios (p< 0.05). Results: Out of 126 caregivers with HIV-infected children, 38 (30.2%) did not adhere to ART. Of the proportion that adhered to ART (88, 69.8%), 49 (55.7%) were male. Most of the children (52, 59.1%) were above two years, but under five years. Fifty (56.8%) of those who adhered had completed 3 months on ART, and the majority were at WHO stage-1 of HIV infection. Analysis of the determinants indicated that children's duration on ART (p=0.001), type of ART regimen (single, double or triple therapy) (p=0.065), type of work done by the caregiver to earn a living (p-value 0.003), time a child was initiated on ART (p=0.002), caregiver-child relationship (p=0.002), caregiver-spousal support (p=0.019), type of support obtained whether monetary or not (p=0.000), when the child was started on ART (p=0.004), the person administering ART (p=0.010), the type of ARVs administered (p=0.001), the caregiver detecting ART side effects (p=0.000), types of adverse effects suffered by the child (p=0.043), time of receiving ART (p=0.047), use of western medicine (p=0.043), healthcare cadre (p=0.002), the kind of attention the healthcare provider offered (p=0.015), and improvements in quality of HIV services (p=0.001) were significantly associated with ART adherence. Conclusion: The study findings indicated that ART adherence among HIV-infected children under five years was suboptimal. This will necessitate continuous engagement and education of caregivers on the prominence of adhering to ART.

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Section: Discussionmentioning

confidence: 94%

Differential Self-Reported Determinants to Antiretroviral Therapy Adherence: Findings from Caregivers of Children Under Five Years Living with Human Immunodeficiency Virus Infection Attending Al-Sabah Hospital, South Sudan

Tong¹,

Atuhairwe²,

Taremwa³

2020

HIV

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“…Early initiation to ART treatment after confirmation of HIV positive improves morbidity and mortality in all stages of HIV infection. 22,[44][45][46] Early initiation of ART treatment reduces HIV transmission since it reduces the plasma HIV levels. 47 Previous studies also suggest that earlier initiation of ART increases the potential to identify patients at risk of poor viral load suppression.…”

Section: Percentage (%)mentioning

confidence: 99%

Current Status Towards 90-90-90 UNAIDS Target and Factors Associated with HIV Viral Load Suppression in Kediri City, Indonesia

Ssekalembe¹,

Isfandiari²,

Suprianto³

2020

HIV

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Introduction: In 2016, UN Member States committed to reduce new HIV infections to fewer than 500,000 annually by 2020, a 75% reduction compared with 2010, reduce AIDS-related deaths to fewer than 500,000 globally as a means of ending AIDS by 2030. The UNAIDS 2020 target is to have 90% of the people living with HIV know their status, 90% of the people living with HIV (who know their HIV status as positive) are already on ART treatment, 90% of people on treatment are virally suppressed. The objective of this study is to determine the current status towards the 2020 90-9-90 UNAIDS target and the factors associated with HIV viral load suppression in Kediri city. Methods: The study was a cross-sectional study in Kediri city. The researcher collected secondary data, carried in-depth interviews, then determined the percentage of HIV-positive patients that did a HIV test and received their results as Positive, the percentage of HIVpositive patients that started ART treatment, the percentage of HIV-positive patients that have viral load suppression from the viral load tests done. A simple bivariate logistic and multivariate logistic regression was used to determine the significant factors that determine viral suppression. Results: The progress towards the 90-90-90 UNAIDS target was at 6.4%, 74.9%, 9.9%. The time taken by the HIV-positive patient to start ART treatment from the time of confirmation of HIV positive (AOR= 83.191,) and decrease in body weight of the patient (AOR=29. 636,) were found to significantly influence viral load suppression. Conclusion:There is a need to scale up HIV case-detection capacity through creating awareness about HIV, HIV testing and counselling and expand the ART services so as to achieve the 90-0-90 UNAIDS target. Early initiation to ART treatment (Test and Treat) and encouraging body gaining behaviors are needed to achieve viral load suppression.

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“…Finally, the favorable evolution of the three cases diagnosed in less advanced stages, with CD4 counts exceeding 200 cells/mm 3 , suggests that the course of HIV infection acquired after the transplant—once recognized and addressed appropriately—can be similar to that of the general population given prompt access to highly active antiretroviral therapy …”

Section: Discussionmentioning

confidence: 95%

Sexual acquisition of HIV infection after solid organ transplantation: Late presentation and potentially fatal complications

Cristelli

Mazolin

Manzardo

et al. 2018

Transplant Infectious Dis

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Antiretroviral Therapy

Cited by 7 publications

References 67 publications

<p>Differential Self-Reported Determinants to Antiretroviral Therapy Adherence: Findings from Caregivers of Children Under Five Years Living with Human Immunodeficiency Virus Infection Attending Al-Sabah Hospital, South Sudan</p>

<p>Differential Self-Reported Determinants to Antiretroviral Therapy Adherence: Findings from Caregivers of Children Under Five Years Living with Human Immunodeficiency Virus Infection Attending Al-Sabah Hospital, South Sudan</p>

<p>Current Status Towards 90-90-90 UNAIDS Target and Factors Associated with HIV Viral Load Suppression in Kediri City, Indonesia</p>

Sexual acquisition of HIV infection after solid organ transplantation: Late presentation and potentially fatal complications

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