Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice

Kang, Ji-Young; Khan, Mohammed Nurul Absar; Park, N.H.; Cho, J.Y.; Lee, M.C.; Fujii, Hitoshi; Hong, Yong‐Ki

doi:10.1016/j.jep.2007.10.032

Cited by 146 publications

(96 citation statements)

References 17 publications

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“…Red algae were reported to contain active secondary metabolites that may inhibit inflammation (Kang et al 2008), prevent or treat gastric ulcers and cancers caused by oxidative stress (Gonzalez et al 1999;Yeh et al 2012), inhibit inflammatory activities by suppressing the production of inflammatory mediators (Khan et al 2007 and induce cancer cell apoptosis in colon (Synytsya et al 2010) and stomach (Kwon & Nam 2007). Natural compounds derived from the edible algae could be used as anti-inflammatory, analgesic and antiulcerogenic therapeutics as they have been taken in alimentation and used in traditional medicines in the last centuries (Dhargalkar & Pereira 2005).…”

Section: Introductionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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“…Sargassum is tropical and sub-tropical brown algae comprising 150 species, common to all oceans except Antarctica (Dar et al, 2007). Sargassum have been studied extensively, and polysaccharides extracted from different Sargassum algae such as S. dentifolium (Amira et al, 2013), S. wightii (Josephine et al, 2008), S. thunbergii and others (Kang et al, 2008) were reviewed and showed the diverse bioactivities such as anti-oxidant, antiinflammatory, anti-genotoxic, and anti-cancer. However, the mechanisms underlying the anti-inflammatory properties of the ethanol extract of Sargauum fulvellum (S. fulvellum) are yet to be established.…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Kim¹,

Kim²,

Jeong³

et al. 2013

Journal of Applied Biological Chemistry

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Recently, algae has been considered as a potential antiinflammatory source due to its distinctive habitat environment exposing to light and high oxygen concentration. In present study, anti-inflammatory effect of brown alga, Sargassum fullvellum ethanol extract (SFEE), was examined. SFEE inhibited not only the production of nitric oxide and pro-inflammatory cytokines (IL-6, IL-1β, TNF-α) but also the expression of inducible nitric oxide synthase and cyclooxygenase 2 in LPS-induced RAW 264.7 cells without affecting cell viability. SFEE also suppressed the expression of nuclear factor kappa B (NF-κB), suggesting that SFEE could affect the expression of inflammation related cytokines and proteins through the regulation of NF-κB. Furthermore, formation of edema of the ear was 40% lower in mice treated with the highest dose (250 mg/kg) of SFEE than in the control mice. Thus, our study showed that SFEE may be a potential therapeutic anti-inflammatory drug.

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“…(intraperitonially) after 1 h of treatment. Total number of writhing was recorded for duration of 20 min after 10 min of acetic acid injection [9].…”

Section: Evaluation Of Analgesic Activitymentioning

confidence: 99%

Antipyretic, analgesic and anti-inflammatory activities of methanol extract of root bark of <i>Acacia jacquemontii</i> Benth (Fabaceae) in experimental animals

Ashfaq¹,

Choudhary²,

Uzair³

et al. 2016

Trop. J. Pharm Res

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Antipyretic, analgesic, and anti-inflammatory activities of the seaweed Sargassum fulvellum and Sargassum thunbergii in mice

Cited by 146 publications

References 17 publications

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Inhibitory Effect of Sargauum fulvellum Ethanolic Extract on LPS-Induced Inflammatory Reaction in RAW 264.7 Mouse Macrophages

Antipyretic, analgesic and anti-inflammatory activities of methanol extract of root bark of <i>Acacia jacquemontii</i> Benth (Fabaceae) in experimental animals

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