Antipsychotic use and the risk of hip/femur fracture: a population-based case–control study

Abstract

Summary This case-control study showed that current use of conventional antipsychotics, but not atypical antipsychotics, seems to be associated with an increased risk of a hip/femur fracture, possibly related to the pharmacological properties of conventional antipsychotics. Furthermore, no evidence for a dose effect was found.

Do Long-Term Side Effects Matter? Evaluating the Risk of Hip Fracture in Subjects With Schizophrenia Over a Decade

“…The study replicates and expands on previous work by other investigators [4][5][6] showing exposure to antipsychotics increases risk of hip fractures in exposed patients. This study 3 retrospectively mines a decade of information from a large national database to study an outcome that is not robustly apparent in smaller, short-term studies.…”

Risk of fractures in patients with multiple sclerosis

“…For a time-dependent analysis we considered age, a history of chronic diseases (asthma, congestive heart failure, rheumatoid arthritis, cerebrovascular disease, 21 noninfectious enteritis and colitis, renal failure, dementia, and epilepsy), as well as a history of falling 1 year to 3 months before the start of each 30-day interval. Any prescriptions for oral GCs, 22,23 statins, antiarrhythmics (excluding digoxin and sotalol), antidiabetics, antidepressants, 24 antipsychotics, 25 hypnotics/ anxiolytics, 26 anticonvulsants, 27 estrogen containing hormone replacement therapy, 28 calcium, vitamin D, bisphosphonates, opioids, or asthma medication 6 months before the start of an interval were also considered as potential confounders. were osteoporotic fractures and 20 concerned other types of fracture, which included fractures of the face bones (n ϭ 2), fractures of the hand (n ϭ 2), fractures of tibia/fibula (n ϭ 6), and fractures of the foot/ankle (n ϭ 10).…”

Esquizofrenia y su asociación con enfermedades médicas crónicas

“…Es importante considerar que la disminución de la densidad mineral ósea y la osteoporosis en EQZ se aprecian particularmente en pacientes en terapia de medicación antipsicótica 40 . Los mecanismos de osteoporosis inducida por antipsicóticos son complejos, pero probablemente el de mayor importancia es la hiperprolactinemia, causada por la mayoría de los antipsicóticos, aunque siendo este evento más marcado con el uso de risperidona, paliperidona y amisulpiride.…”