Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines

Pae, Chi‐Un; Yoon, Chong‐Hyeon; Kim, Tae-Suk; Kim, Jung-Jin; Park, Sung-Hwan; Lee, Chang-Uk; Lee, Soo-Jung; Lee, Chul; Paik, In‐Ho

doi:10.1016/j.intimp.2005.10.004

Cited by 66 publications

(47 citation statements)

References 35 publications

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“…HAL treatment decreases both serum (Monteleone et al, 1997) and CSF (McAllister et al, 1995) levels of IL-2 in patients with schizophrenia. A recent study has shown that IL-6 plasma levels in patients with schizophrenia, after antipsychotic treatment, is lower than before (Pae et al, 2006). In addition, antipsychotics normalize the higher amounts of TNF-a released from monocytes isolated from the peripheral blood of patients with schizophrenia and stimulated by LPS (Kowalski et al, 2001).…”

Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

“…These observations extend our previous results, in which prenatal LPS-exposed rats showed increased serum levels of IL-2 at the age of 100 and 300 days and serum IL-6 levels at 100 days of age (Borrell et al, 2002) and they highlight that changes in serum IL-6 levels induced by prenatal LPSexposure seem to be age-dependent. Several studies show increased levels of IL-6 in patients with schizophrenia (Monteleone et al, 1997;Pae et al, 2006). Moreover, it has been recently suggested that IL-6 may be involved in the clinical symptomatology and clinical improvement of schizophrenia (Pae et al, 2006).…”

Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

“…Several studies show increased levels of IL-6 in patients with schizophrenia (Monteleone et al, 1997;Pae et al, 2006). Moreover, it has been recently suggested that IL-6 may be involved in the clinical symptomatology and clinical improvement of schizophrenia (Pae et al, 2006). Nonetheless, there is an increasing body of evidence that cytokine abnormalities play a role in the pathophysiology of schizophrenia, and encouraging results and some controversial findings have been simultaneously produced.…”

Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

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Neurobehavioral and Immunological Consequences of Prenatal Immune Activation in Rats. Influence of Antipsychotics

Romero

Ali

Molina‐Holgado

et al. 2006

Neuropsychopharmacol

128

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Increasing evidence suggests that pre-or perinatal events that influence the immune system contribute to the development of behavioral or neuropsychiatric disorders. For instance, exposure of pregnant rats to the bacterial endotoxin lipopolysaccharide (LPS) disrupts sensorimotor information processing, as assessed by the prepulse inhibition test (PPI), and also the immune function in adult offspring, which might be of particular relevance as regards schizophrenia. However, the consequences of maternal LPS exposure during pregnancy on synaptic functioning in adult offspring and, more importantly, the therapeutic opportunity to re-establish PPI and immune function have still to be demonstrated. In this work, we analyzed the consequences of prenatal LPS exposure on dopaminergic neurotransmission and presynaptic markers in adult brain areas related to PPI circuitry. In addition, we tested whether oral treatment with the typical antipsychotic drug haloperidol (HAL) could reinstate PPI performances and cytokine serum levels in six-month-old male rats with prenatal LPS exposure. Both sensory information processing deficits and immune anomalies induced by prenatal exposure to LPS were accompanied by changes in dopaminergic neurotransmission and synaptophysin expression. It is important to note that PPI disruption and serum increases in cytokines induced by prenatal LPS exposure were both reversed by HAL. Taken together, these results demonstrate the critical influence of prenatal immune events on the functioning of adult nervous and immune systems, in association with the putative role of the immune system in the development of behavior relevant to schizophrenia.

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Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

Section: Hal Alleviates Ppi and Immune Alterations Induced By Prenatamentioning

confidence: 99%

See 1 more Smart Citation

Neurobehavioral and Immunological Consequences of Prenatal Immune Activation in Rats. Influence of Antipsychotics

Romero

Ali

Molina‐Holgado

et al. 2006

Neuropsychopharmacol

128

View full text Add to dashboard Cite

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“…It was previously found that IL-6 decreased significantly after antipsychotic therapy in FEP and that this change was positively correlated with clinical improvement [32]. Therefore, it was suggested that IL-1β, IL-6 and TGF-β might represent disease state markers [21].…”

Section: Immunoinflammatory Biomarkersmentioning

confidence: 93%

Biomarkers and schizophrenia: a qualitative review

Silva¹,

Pinto²

2017

IJCNMH

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Schizophrenia (SCZ) is a psychiatric disorder with a broad spectrum of biological and clinical manifestations of yet not completely clear pathophysiological mechanisms. Several lines of evidence have been supporting the idea that immunoinflammatory, oxidative, hormonal and cellular dysfunctions are implicated on the biomolecular basis of SCZ. However, accurate diagnosis and selection of appropriate treatments remains challenging as a result of the scarcity of objective tests. Furthermore, there is a compelling need to find biomarkers that could predict drug response and tailor pharmacological treatment, particularly in drug-naïve first episode psychosis (FEP). Hence, numerous technologies have been employed in order to search for SCZ biological markers, but evidence relating them to treatment efficacy is lacking. In this regard, some preliminary data suggest promising results. The current review provides information on: (1) potential biomarkers associated with biological disturbances and (2) biological markers associated with treatment response.

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“…Полученные дан-ные находятся в соответствии с гипотезой активации Т-хелперов 2-го типа (Th-2), что приводит к дисбалансу Th-1/Th-2 иммунного ответа, изменению цитокинового профиля, нарушениям нейроим-мунного взаимодействия и передаче сигналов между нервной и им-мунной системами (Schwarz M.J. et al, 2001;Urakubo A. et al, 2001;Kim Y.K. et al, 2004;Nawa H., Takei N., 2006;Pae C.U. et al, 2006;Strous R.D.…”

Section: методы иммунокоррекции при шизофренииunclassified

Technology of Immunocorrection at Mental Disorders

Vetlugina¹,

Nevidimova²,

Lobacheva³

et al. 2010

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Antipsychotic treatment may alter T-helper (TH) 2 arm cytokines

Cited by 66 publications

References 35 publications

Neurobehavioral and Immunological Consequences of Prenatal Immune Activation in Rats. Influence of Antipsychotics

Neurobehavioral and Immunological Consequences of Prenatal Immune Activation in Rats. Influence of Antipsychotics

Biomarkers and schizophrenia: a qualitative review

Technology of Immunocorrection at Mental Disorders

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