Antipsychotic Medication Prescribing Trends in Children and Adolescents

Harrison, Joyce N.; Cluxton-Keller, Fallon; Gross, Deborah

doi:10.1016/j.pedhc.2011.10.009

Cited by 144 publications

(95 citation statements)

References 35 publications

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“…Although the secondgeneration antipsychotics have a lesser propensity for extra-pyramidal side effects they are associated with metabolic disturbance and weight gain, to which adolescents may be more vulnerable than their adult counterparts (Stigler et al, 2004;Pogge et al, 2005). Other factors suggested to have been involved in increasing antipsychotic prescribing are the expanding evidence base in relation to antipsychotic use in this age group (Harrison et al, 2012) and a lack of availability of non-pharmacological treatments (Thomas et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Woods¹,

Shannon²,

Davidson³

et al. 2015

Ir. j. psychol. Med.

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Objective: to report new prescriptions of psychotropic medications among adolescents presenting with new onset psychotic symptoms during a five-year period. Results: A total of 100 patients (88.5%) were prescribed some form of psychotropic medication.Over three-quarters of patients received an antipsychotic as their first medication. Risperidone (45.8%), olanzapine (24.0%) and chlorpromazine (12.5%) were the most commonly prescribed first-line antipsychotic medications. Of a total of 160 antipsychotic prescriptions, 81 (50.6%) were off-label. Prescriptions were most likely to have been deemed off-label due to medications not being licensed in under-18s (71.6% of off-label prescriptions) but other reasons were medications being used outside licensed age ranges (23.5%) and outside licensed indications (4.9%).Conclusions: This is the first study examining psychotropic prescribing patterns in a complete sample of all children and adolescents presenting with early onset psychotic episodes in a single geographical area. The observation of risperidone as the most commonly-prescribed antipsychotic was in keeping with previous studies in child and adolescent populations. Rates of off-label prescribing were lower than previously observed although our study was the first to investigate offlabel prescribing solely in children and adolescents presenting with psychotic symptoms.2

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Section: Introductionmentioning

confidence: 99%

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Woods¹,

Shannon²,

Davidson³

et al. 2015

Ir. j. psychol. Med.

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“…Specific child psychiatric disorders include Tourette's syndrome and behavioural symptoms associated with autistic disorder, childhood schizophrenia, and bipolar disorder. 15 National guidelines do recommend antipsychotics for the relatively rare condition of psychotic depression and as a possible intervention for treatment-resistant cases of severe depression and OCD. In clinical practice, these agents may be prescribed 'offlabel' for patients who do not have a diagnosis of SMI (severe mental illness) in their clinical notes.…”

mentioning

confidence: 99%

Antipsychotic medication prescribing trends in a tertiary care hospital

Siddiqui

Shende

Mahajan

et al. 2016

Int J Basic Clin Pharmacol

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“…La Food and Drug Administration (FDA) ha aprobado el uso de antipsicóticos en niños y adolescentes con graves trastornos emocionales y del comportamiento que son resistentes a otras formas de tratamiento, como síndrome de Guilles de la Tourette, trastorno autista, esquizofrenia y trastorno bipolar (21). Cabe destacar que, al tratarse de un listado cerrado de medicamentos, se entiende por qué más de 84,1 % de los pacientes son tratados con seis de los medicamentos incluidos en el mismo, aunque existe la opción de emplear medicamentos por fuera del listado, solicitados a través de la evaluación de un comité técnico científico o una tutela.…”

Section: Discussionunclassified

Patrones de prescripción de antipsicóticos en pacientes afiliados al Sistema de Seguridad Social en Salud de Colombia

Machado‐Alba

Morales-Plaza

2013

biomedica

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Introducción. La esquizofrenia altera la percepción del individuo, el pensamiento, el afecto y el comportamiento. El tratamiento farmacológico puede mejorar estas manifestaciones. Objetivo. Determinar los patrones de prescripción de medicamentos antipsicóticos en un grupo de pacientes afilados al Sistema General de Seguridad Social en Salud de Colombia. Materiales y métodos. Se llevó a cabo un estudio descriptivo sobre base de datos de 6,2 millones de personas. Se seleccionaron los pacientes medicados con antipsicóticos, de ambos sexos, todas las edades, con tratamiento continuo de marzo a junio de 2012, y residentes de 57 ciudades colombianas. Se diseñó una base de datos sobre consumo de medicamentos, obtenidos por la empresa que dispensa dichos fármacos. Resultados. Se estudiaron 3.075 pacientes con edad promedio de 55,8±21,5 años; 50,3 % eran mujeres; 81,9 % recibían monoterapia y, 18,1 %, dos o más antipsicóticos. El orden de prescripción fue: atípicos, 77,1 %, y clásicos, 31,9 %. Los medicamentos más utilizados fueron: quetiapina (30,3 %), clozapina (23,7 %), levomepropamiza (18,4 %) y risperidona (14,9 %). Las combinaciones más frecuentes fueron: haloperidol más levomepromazina (n=67; 12,1 % de las asociaciones), clozapina más pipotiazina (n=54; 9,7 %) clozapina más risperidona (n=45; 8,1 %), quetiapina más levomepromazina (n=40; 7,2 %). Los medicamentos prescritos concomitantemente más frecuentes fueron: antidepresivos (n=998; 32,5 %); ansiolíticos (n=799; 26,0 %); hipolipemiantes (n=672; 21,9 %); antiparkinsonianos (341; 11,1 %) y antidiabéticos (n=327; 10,6 %). Conclusiones. Predominan los hábitos de prescripción de medicamentos de alto valor terapéutico, principalmente en la monoterapia antipsicótica. En la mayoría, se emplean en dosis superiores a las recomendadas. Se plantea la necesidad de diseñar estrategias educativas para corregir algunos hábitos de prescripción e investigaciones que evalúen la efectividad del tratamiento.Palabras clave: esquizofrenia, prescripciones de medicamentos, antipsicóticos, clozapina, haloperidol, farmacoepidemiología, Colombia. doi: http://dx.doi.org/10.7705/biomedica.v33i3.1529 Antipsychotic prescription patterns in patients affiliated to the Social Security Health System in ColombiaIntroduction: Schizophrenia alters individual perception, thought, affection and behavior. Drug therapy can improve these manifestations. Objective: To determine prescription patterns of antipsychotic drugs in a group of patients affiliated to the Social Security Health System in Colombia. Materials and methods:This was a descriptive study with a 6.2 million people database. We selected 3,075 patients medicated with antipsychotics, of both sexes, and all ages, with continuous treatment from March to June, 2012, and residing in 57 Colombian cities. We designed a database on drug consumption, obtained by the company that distributes the drugs to the patients. Results: A total of 3,075 patients were studied, with an age mean of 55.8 ± 21.5 years; 50.3% of the participants were women. Of all pa...

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Antipsychotic Medication Prescribing Trends in Children and Adolescents

Cited by 144 publications

References 35 publications

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Psychotropic prescribing patterns among adolescents in Northern Ireland presenting with psychotic symptoms during a 5-year period

Antipsychotic medication prescribing trends in a tertiary care hospital

Patrones de prescripción de antipsicóticos en pacientes afiliados al Sistema de Seguridad Social en Salud de Colombia

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