Antipsychotic Medication during Pregnancy and Lactation in Women with Schizophrenia: Evaluating the Risk

Patton, S; Misri, Shaila; Corral, Maria; Perry, Katherine; Kuan, Annie J

doi:10.1177/070674370204701008

Cited by 70 publications

(40 citation statements)

References 59 publications

(37 reference statements)

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“…Data regarding phenothiazines are less consistent. A meta-analyses has found that first trimester exposure to phenothiazines may be associated with a slight increase in relative risk of fetal anomalies in some women with schizophrenia (65).…”

Section: Antipsychotic Agentsmentioning

confidence: 99%

Pharmacotherapy of Depression in Pregnancy

Patkar¹,

Bilal²,

Masand³

2004

Annals of Clinical Psychiatry

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About 20% of pregnant women experience clinical depression. Inadequate treatment of depression has been associated with adverse outcomes in the mother as well as the newborn. Clinicians are often uncertain about pharmacological interventions to treat depressed pregnant women due to concerns regarding fetal exposure to medications. Moreover newer antidepressants with different pharmacological profiles and little data on fetal risk continue to be introduced at a brisk pace. Accumulating data from pharmaceutical registries, cohort studies, toxicology centers, some prospective studies, and case series have permitted certain guidelines for antidepressant use during pregnancy. We review the safety profiles of commonly used antidepressants, discuss clinical decision making based on risk-benefit considerations and make recommendations for pharmacological treatment of depressed women during pregnancy.

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Section: Antipsychotic Agentsmentioning

confidence: 99%

Pharmacotherapy of Depression in Pregnancy

Patkar¹,

Bilal²,

Masand³

2004

Annals of Clinical Psychiatry

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“…The risk of using antipsychotic medications during antenatal period and on breast feeding remains uncertain. There is not clear if antipsychotic drugs are associated with major malformations [41].…”

Section: Schizophreniamentioning

confidence: 99%

Psychiatric Disorders during Pregnancy and Postpartum

Sharma¹,

Singh²,

Tempe³

et al. 2017

J Preg Child Health

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Pregnancy is the most beautiful and memorable time in a woman's life. Apart from medical and obstetrical challenges it involves a of lot emotional, psychological and social aspects too. Although women having medical and obstetrical disorders commonly seek treatment, psychological problems are often not addressed. A female may continue to live in a state of emotional turmoil and may attribute these changes to the hormonal changes in the body due to pregnancy. Psychiatric disorders which remain untreated can disrupt the social life and can have undesirable effects on fetal and neonatal development, so it becomes important to identify women at risk for developing psychiatric disorders during pregnancy and postpartum and initiate timely management. Although the American College of Obstetrics and Gynaecology recommended strongly considering screening pregnant women for depression in 2006, it is not done as a routine.

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“…Women with schizophrenia may discontinue their medications when trying to conceive or upon discovering they are *Address correspondence to this author at the Comprehensive Family Care Center, Montefiore Medical Center, 1621 Eastchester Road, Bronx, NY 10461, USA; Tel: (718) 405-8267; Fax: (718) 405-8050; E-mail: afrieder@montefiore.org pregnant, rendering them vulnerable to an exacerbation or relapse of their illness during pregnancy [4][5][6]. Psychosis during pregnancy is of great concern as it can lead to fetal distress, denial of pregnancy, failure to participate in prenatal care, and/or failure to recognize the signs of labor [6][7][8].…”

Section: Preconception Carementioning

confidence: 99%

“…The risks of untreated mental illness on the pregnancy need to be weighed against the risks of the psychotropics the woman may be taking [3,5,6]. Risk/benefit assessment and decision with respect to treatment should be individualized on a case-by-case basis.…”

Section: Reproductive Decisionsmentioning

confidence: 99%

Preconception Counseling for Women with Schizophrenia

Frieder¹

2010

CWHR

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This article outlines guidelines for preconception counseling of women with schizophrenia. Preconception care creates the opportunity to address risky behaviors, change unhealthy lifestyles, enhance the patient's knowledge about the genetics of her disease and the risk for her offspring, improve parenting skills, mobilize resources and the necessary support system in a timely manner and ultimately improve the health and quality of life of both the woman and her offspring.Women with schizophrenia are in particular need of preconception interventions. They are at a high risk of relapse during pregnancy unless their illness is treated. Psychosis during pregnancy can lead to fetal distress, denial of pregnancy, failure to participate in prenatal care and to recognize the signs of labor. Women with schizophrenia are at high risk of fetal malformations, obstetrical and neonatal complications and postpartum psychosis. In addition, schizophrenia is associated with homelessness and low socioeconomic status. Moreover, women with schizophrenia have poor social support and often lose the custody of their children.Identification and treatment of women with severe mental illness prior to conception is essential to reducing negative outcomes.

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Antipsychotic Medication during Pregnancy and Lactation in Women with Schizophrenia: Evaluating the Risk

Cited by 70 publications

References 59 publications

Pharmacotherapy of Depression in Pregnancy

Pharmacotherapy of Depression in Pregnancy

Psychiatric Disorders during Pregnancy and Postpartum

Preconception Counseling for Women with Schizophrenia

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