Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa

Guzmán, Eduardo Lozano; Pérez, Cuauhtémoc; Zavala, Miguel; Acosta-Viana, Karla Y.; Pérez, Salud

doi:10.1016/j.phymed.2008.02.013

Cited by 12 publications

(19 citation statements)

References 11 publications

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“…It has been reported that amphotericin B complexed with cholesterol is at least four times more active than amphotericin B alone in L. donovani-infected hamsters [35]. Moreover, some fatty acid derivatives have been reported with antileishmanial and antimalarial activity [36][37][38][39]. Hence, remarkable antiprotozoal activity of the PE extracts of LC and LCC could be due to their fatty acids and sterol constituents.…”

Section: Discussionmentioning

confidence: 99%

Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi

Orhan¹,

Şener²,

Kaiser³

et al. 2013

Turk J Bioch

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Section: Discussionmentioning

confidence: 99%

Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi

Orhan¹,

Şener²,

Kaiser³

et al. 2013

Turk J Bioch

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“…Extraction procedure and isolation of the evaluated compound were done as described by Guzman et al, 2008.…”

Section: Cruzimentioning

confidence: 99%

“…(S. villosa) it is a Leguminoceae, widely distributed in the south of Mexico. It had been previously reported their in vitro antiprotozoal properties (Guzman et al, 2004), and from the leaves was isolated the compound (8-hydroxymethylen)-trieicosanyl acetate, with antiprotozoal activity in vitro against T. cruzi (3.3 and 6.6 μg/mL) (Guzman et al, 2008) and in vivo, in infected mice (8.4 and 33.6 μg/g) beginning the treatment with the compound immediately after the inoculation (Jimenez-Coello et al, 2010), however, this condition was hypothetical, because in a real scenario, a patient would begin a treatment some days after of the infection. The aim of this study was to determine antiprotozoal activity in vivo against of T. cruzi (amastigotes and trypomastigotes) during the established acute phase of the Chagas´ disease and the infection development after the suppression of treatment with the evaluated compound.…”

Section: Introductionmentioning

confidence: 99%

<i>In Vivo</i> Activity of (8-Hydroxymethylen)-Trieicosanyl Acetate against <i>Trypanosoma cruzi</i> during Acute Phase of the Infection

Jiménez‐Coello

Acosta-Viana²,

G³

et al. 2011

Afr. J. Trad. Compl. Alt. Med.

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The antiprotozoal activity in vivo against Trypanosoma cruzi of (8-hydroxymethylen)-trieicosanyl acetate was evaluated in BALB/c mice during the acute phase of Chagas' disease (15 days after infection). Animals were treated during 15 days at doses of 16.8 and 33.6 µg/g, reduced parasitemia of 77.6 and 64.1% was observed respectively, in comparison with positive control mice (allopurinol 8.5 µg/g) which reduced only 29.7%. Also, amastigote nests in cardiac tissue were significant reduced in treated mice groups. The regression of effect induced after the suppression of the treatment with the compound was evaluated; animals were infected and simultaneously began the treatment with the compound during 20 days (16.8 and 33.6 µg/g). Mice were monitored after the end of the treatment for one more week. A good antitrypanosomal response was observed (66.1 and 68.9% less than untreated mice) during treatment, but 8 days after suspension of treatment, parasitemia level increased, reducing only 58.6 and 56.29 % respectively in treated animals compared with no treated. RésuméL'activité in vivo contre antiprotozoaires Trypanosoma cruzi de (8-hydroxymethylen)-acétate de trieicosanyl a été évaluée chez des souris BALB / c pendant la phase aiguë de la maladie de Chagas (15 jours après l'infection). Les animaux ont été traités pendant 15 jours à des doses de 16,8 et 33,6 mg / g, la parasitémie réduite de 77,6 et 64,1% a été observée, respectivement, en comparaison avec les souris de contrôle positif (allopurinol 8,5 mg / g), qui réduit que de 29,7%. En outre, les nids amastigote dans le tissu cardiaque ont été réduits dans les groupes importants chez les souris traitées. La régression de l'effet induit après la suppression du traitement avec le composé a été évalué, les animaux ont été infectés et, simultanément, a commencé le traitement avec le composé pendant 20 jours (16,8 et 33,6 mg / g). Les souris ont été suivis après la fin du traitement pour une semaine de plus. Une bonne réponse a été observée antitrypanosomal (66,1 et 68,9% de moins que les souris non traitées) en cours de traitement, mais 8 jours après la suspension du traitement, le niveau de la parasitémie a augmenté, réduisant seulement 58,6 et 56,29% respectivement chez les animaux traités par rapport à aucun traitement.

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“…14 estilbenoides, dentre outros, como constituintes químicos de maior ocorrência, associados às atividades antibacteriana, citotóxica, antifúngica, antioxidante e hepatoprotetora relatadas. [17][18][19][20][21] O gênero Senna se diferencia quimicamente pela ocorrência de alcaloides piperidínicos tipo alcaloides 2,6-dialquil-piperidin-3-óis, raros na natureza. 17 Figura 1.…”

Section: Bioprospecção E a Descoberta De Substâncias Bioativasunclassified

Spectaline, cassine and semi-synthetic analogues as potential candidate drugs for the treatment of Alzheimer disease

Silva¹,

Viegas²,

Santos³

et al. 2010

Revista Virtual De Química

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Spectaline, Cassine and Semi-Synthetic Analogues as Potential Candidate Drugs for the Treatment of Alzheimer DiseaseAbstract: This paper describes the main steps in the study of Senna spectabilis, as part of our bioprospection studies, with the isolation of spectaline, cassine and other piperidine alkaloids, as well as the preparation of semi-synthetic analogues, and the studies of their pharmacological and toxicological properties, which led to the establishment of two candidate drugs for the treatment of Alzheimer disease.Keywords: spectaline; cassine; Senna spectabilis; acetylcholinesterase inhibitor; bioprospection. ResumoEste artigo descreve o estudo fitoquímico de Senna spectabilis que conduziu ao isolamento de espectalina, cassina e outros alcaloides piperidínicos, a obtenção de análogos semi-sintéticos da espectalina e cassina, e a avaliação de suas propriedades farmacológicas e toxicológicas que resultaram no estabelecimento de dois candidatos a fármacos para o tratamento da doença de Alzheimer (DA).

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Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa

Cited by 12 publications

References 11 publications

Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi

Lycopodium clavatum and Lycopodium complanatum subsp. chamaecyparissus ekstrelerinin antiprotozoal aktivitesi ve sitotoksisitesi

<i>In Vivo</i> Activity of (8-Hydroxymethylen)-Trieicosanyl Acetate against <i>Trypanosoma cruzi</i> during Acute Phase of the Infection

Spectaline, cassine and semi-synthetic analogues as potential candidate drugs for the treatment of Alzheimer disease

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