Antiproliferative Properties of Oleuropein in Human Osteosarcoma Cells

Morana, Jose M; Leal-Hernande, Olga; Canal-Macias, Maria L.; Roncero-Martín, Raúl; Guerrero-Bonmatty, Rafael; Aliaga, Ignacio; Zamorano, Juan Diego Pedrera

doi:10.1177/1934578x1601100418

Cited by 15 publications

(20 citation statements)

References 9 publications

(6 reference statements)

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“…Exposure of MG‐63 and Saos2 human osteosarcoma cells to oleuropein resulted in cytotoxic effects on both MG‐63 (IC50 247.4–475.0 μM) and Saos2 (IC50 798.7–359.9 μM) cells .…”

Section: Anticancer Effects Of Oleuropein: In Vitro Studiesmentioning

confidence: 99%

Anticancer effects of oleuropein

2017

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Cancer cells exhibit enhanced proliferation rate and a resistance to apoptosis. Epidemiological studies suggest that olive oil intake is associated with a reduced risk of cancer. Olive oil, olives, and olive leaves contain many polyphenols, including oleuropein. Recently, several studies have demonstrated that oleuropein inhibits proliferation and induces apoptosis in different cancer cell lines. In addition, anticancer effects of oleuropein have been seen in animal studies. These effects are associated with oleuropein's ability to modulate gene expression and activity of a variety of different signaling proteins that play a role in proliferation and apoptosis. This article summarizes the existing in vitro and in vivo studies focusing on the anticancer effects of oleuropein and its effects on key signaling molecules. © 2017 BioFactors, 43(4):517-528, 2017.

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“…Exposure of MG‐63 and Saos2 human osteosarcoma cells to oleuropein resulted in cytotoxic effects on both MG‐63 (IC50 247.4–475.0 μM) and Saos2 (IC50 798.7–359.9 μM) cells .…”

Section: Anticancer Effects Of Oleuropein: In Vitro Studiesmentioning

confidence: 99%

Anticancer effects of oleuropein

2017

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“…We congratulate Imran and colleagues for such an extensive search of the literature published recently about the antitumoral effects of oleuropein. Additionally, we would like to add that our group have also published results about the antitumoral effects of oleuropein in human osteosarcoma cells (Moran et al, 2016) showing that oleuropein had obvious cytotoxic effects on human osteosarcoma cells in a concentration-and time-dependent manner, with similar toxic effects on both cell lines tested (IC50 range from 247.4-475.0 µM for MG63 cells and from 359.9-798.7 µM for Saos2 cells). The previously published review of Shamshoum and colleagues (2017) already reported those findings in human osteosarcoma cells as well as others not included in the recent study of Imran and colleagues (2018) (meshotelioma (Marchetti et al, 2015), pancreatic (Goldsmith et al, 2015) and neuroblastoma (Secme, Eroglu,…”

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confidence: 99%

Antitumor Perspectives of Oleuropein and Its Metabolite Hydroxytyrosol: Recent Updates

Imran

Nadeem

Gilani

et al. 2018

Journal of Food Science

103

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Olive fruit is a significant and promising source of potential bioactive compounds such as oleuropein and hydroxytyrosol. Oleuropein is the ester of elenolic acid and 3,4-dihydroxyphenyl ethanol (HT). It is the main glycoside in olives, the degradation of which results in the formation of hydroxytyrosol in olive oil. Both plays a significant role in the reduction of coronary heart diseases and a certain type of cancers. Both olive oil phenols have an effective role counter to cell proliferation, cell growth, migration, invasion, and angiogenesis. They down regulate the expression of BCL-2 and COX-2 proteins, and reduced DNA damage. Hydroxytyrosol and oleuropein inhibited the multiple stages in colon carcinogenesis; initiation, promotion, and metastasis. They also provide protection against various human cancers including colorectal, skin, breast, thyroid, digestive, lung, brain, blood, and cervical. This review article discusses the anticancer perspectives and mechanisms of oleuropein and hydroxytyrosol in cell cultures and animal and human studies.

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“…We congratulate Imran and colleagues for such an extensive search of the literature published recently about the antitumoral effects of oleuropein. Additionally, we would like to add that our group have also published results about the antitumoral effects of oleuropein in human osteosarcoma cells (Moran et al., ) showing that oleuropein had obvious cytotoxic effects on human osteosarcoma cells in a concentration‐ and time‐dependent manner, with similar toxic effects on both cell lines tested (IC50 range from 247.4‐475.0 µM for MG63 cells and from 359.9‐798.7 µM for Saos2 cells). The previously published review of Shamshoum and colleagues () already reported those findings in human osteosarcoma cells as well as others not included in the recent study of Imran and colleagues () (meshotelioma (Marchetti et al., ), pancreatic (Goldsmith et al., ) and neuroblastoma (Secme, Eroglu, Dodurga, & Bagci, )).…”

mentioning

confidence: 91%