Antiproliferative potential of Andean Berry (Vaccinium meridionaleSwartz) juice in combination with Aspirin in human SW480 colon adenocarcinoma cells

Abstract

Andean Berry (Vaccinium meridionale Sw.) is a South American fruit rich in phytochemicals with promising anti‐cancer properties as co‐adjuvants to nonsteroidal anti‐inflammatory drugs such as Aspirin. This study aimed to evaluate the antiproliferative potential of Andean Berry Juice (ABJ) in combination with Aspirin in human SW480 colon adenocarcinoma cells. ABJ primarily contained 3,4‐dihydroxybenzoic and chlorogenic acids. The combined treatment of ABJ (IC50: 30.0 ± 0.11%) and Aspirin (IC50: 20.0 ± 0.57) exhibited a higher (p < .01) antiproliferative effect than each counterpart. Moreover the same mixture displayed a lower reduced glutathione/oxidized glutathione ratio (GSH/GSSG) than the untreated cells. ABJ‐Aspirin combination induced late apoptosis stage without stimulating mitochondrial depolarization and prompted phosphatidylserine relocalization. These results emphasize the antiproliferative potential of bioactive compounds from ABJ and Aspirin combinations. Practical applications Natural products such as Andean Berry (V. meridionale Sw.) juice (ABJ) contains antioxidant polyphenols that could reduce the need to use non‐steroidal anti‐inflammatory drugs, currently employed in cancer treatment, to prevent its side effects. The high abundance of polyphenols from this underutilized berry could stimulate the standardization of its production and industrial exploitation to be transformed into suitable food products delivering natural bioactive compounds with potential anti‐cancer effects in vitro.

Gold Nanoparticles Synthesized with Common Mullein (Verbascum thapsus) and Castor Bean (Ricinus communis) Ethanolic Extracts Displayed Antiproliferative Effects and Induced Caspase 3 Activity in Human HT29 and SW480 Cancer Cells

“…Despite no reports for green synthesized AuNPsCE inducing ROS in colorectal cancer cells, phytochemicals from R. communis leaves such as p-coumaric acid have been linked to ROS generation, inducing further apoptosis and a fall in the mitochondrial membrane potential [ 57 ]. This effect has been observed in SW480 cells treated with phenolic-rich berries extracts [ 65 ]. R. communis leaves extracts induce ROS in LPS-stimulated murine RAW264.7 macrophages, acting as critical mediators of several pro-inflammatory responses, such as the canonical pathway or even NLRP3 inflammasome activation [ 34 , 39 ].…”

Pangenomes as a Resource to Accelerate Breeding of Under-Utilised Crop Species

“…[76] RNA-seq/transcriptome assembly [78] Vaccinium meridionale Agraz or Colombian Berry Phylogenetic relationships within the Vaccinieae tribe [205] Chemical, antimicrobial and molecular characterisation [206] Characterisation of phenotypic plasticity [207] Antiproliferative potential of Agraz juice [208] Author…”

Evaluation of mixtures of maltodextrin and gum Arabic for the encapsulation of Andean blueberry (Vaccinium meridionale) juice by freeze–drying

“…Andean blueberry juices are highly appealing in the growing market of functional beverages. It has been suggested by several in vitro studies that these juices exhibit pro‐apoptotic and antiproliferative effects in transformed leukaemic and colorectal cancer cell lines (Arango‐Varela et al ., 2021, 2022). Given their sensory appealing features, their high concentration of phenolic compounds, in particular of anthocyanins, and their bioactivity (Garzón et al ., 2010; Maldonado‐Celis et al ., 2014; Bravo et al ., 2016; Agudelo et al ., 2018; Gallego‐Peláez et al ., 2021), their transformation into more stable products with different functionalities as ingredients have arisen interest (Alzate‐Arbeláez et al ., 2019; Estupiñan‐Amaya et al ., 2020; Garzón et al ., 2021).…”