Antiproliferative effects of zerumbone-pendant derivatives on human T-cell lymphoid cell line Jurkat cells

Utaka, Yoshimi; Kashiwazaki, Gengo; Tajima, Sachiko; Fujiwara, Yuko; Sumi, Keitaro; Itoh, Tomohiro; Kitayama, Takashi

doi:10.1016/j.tet.2019.01.038

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…It was shown that ZER altered the total lipid and fatty acid profile in cancer cells, inducing marked changes in the phospholipid/cholesterol ratio [93]. In addition, the anticancer activity was assessed on Jurkat cells, human T cell leukemia, and it was found that ZERpendant derivatives showed antiproliferative effects (IC 50 values as low as 1-10 µM for most derivatives) [94]. A recent study reported that ZER inhibited cell migration of human esophageal squamous cancer by suppressing Rac1 expression, which is achieved through promoting Rac1 ubiquitination and degradation [95].…”

Section: Anticancer Activitymentioning

confidence: 99%

Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

et al. 2021

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The genus Zingiber consists of about 85 species and many of these species are used as food, spices, and medicines. One of the species, Zingiber montanum (J. Koenig) Link ex A. Dietr. is native to Southeast Asia and has been extensively used as traditional medicines and food. The aim of this review was to collect and critically analyze the scientific information about the bioactive compounds and pharmacological activities of Z. montanum with focus on one of the main components, zerumbone (ZER). Various studies have reported the analysis of volatile constituents of the essential oils from Z. montanum. Similarly, many phenylbutanoids, flavonoids and terpenes were also isolated from rhizomes. These essential oils, extracts and compounds showed potent antimicrobial, anti-inflammatory and antioxidant activities among others. Zerumbone has been studied widely for its anticancer, anti-inflammatory, and other pharmacological activities. Future studies should focus on the exploration of various pharmacological activities of other compounds including phenylbutanoids and flavonoids. Bioassay guided isolation may result in the separation of other active components from the extracts. Z. montanum could be a promising source for the development of pharmaceutical products and functional foods.

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Section: Anticancer Activitymentioning

confidence: 99%

Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

et al. 2021

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Novel Derivatives Based on Zerumbone Scaffold as Potential Anticancer Inhibitors

Hieu

Kim

et al. 2022

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A two-steps procedure was applied to couple zerumbone, a natural sesquiterpene, with thiols 8a-k to yield a small library of ten novel zerumbone derivatives 9a-k with full data of spectra including 1H-, 13C-NMR, and HRMS. The tautomerization of 9a, 9b, and 9c was found in DMSO and discussed in the case of 9c. The series of 9a-k together with zerumbone 1 were evaluated for their in vitro cytotoxic activity using three human cancer cell lines HepG2, A549, and HeLa. The results showed that all zerumbone derivatives expressed the cytotoxic activity against HepG2, A549, and HeLa cells stronger than that of zerumbone from 4-20 folds.

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Antiproliferative effects of zerumbone-pendant derivatives on human T-cell lymphoid cell line Jurkat cells

Cited by 2 publications

References 19 publications

Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

Bioactive Compounds from Zingiber montanum and Their Pharmacological Activities with Focus on Zerumbone

Novel Derivatives Based on Zerumbone Scaffold as Potential Anticancer Inhibitors

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