Antiproliferative effects of palladium(II) complexes of 5-nitrosopyrimidines and interactions with the proteolytic regulatory enzymes of the renin–angiotensin system in tumoral brain cells

Illán‐Cabeza, Nuria A.; García-García, Antonio R.; Martínez-Martos, José Manuel; Ramírez-Expósito, María Jesús; Moreno‐Carretero, Miguel N.

doi:10.1016/j.jinorgbio.2013.06.005

Cited by 24 publications

(17 citation statements)

References 44 publications

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“…This result may be assigned to the positive charge of the metal that increases the acidity of the coordinated ligand bearing protons, and induces stronger hydrogen bonds . A suitable choice of the nature of the metal ion anion and coordination geometry has a profound effect on the biological behavior of the complex by altering the binding ability to DNA . Metal has been prompted oxidative tissue injury by the action of the free radical in definite pathway which is analogous to the Fenton reaction, as explained by Gaetke and Chow .…”

Section: Discussionmentioning

confidence: 99%

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Zahan

Rahi

Sheikh

et al. 2018

Applied Organom Chemis

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Nickel is a fundamental element for healthy life for human and higher animals. For biological importance, its complexation with bioactive ligand is worth to be studied with the aim to understand its function. Using mouse peritoneal cancer model, MTT colorimetric assay and anticancer activity analysis, we examined the role of nickel(ll) complex in growth inhibition of cancer cells. A novel nickel(ll) complex was synthesized and characterized using physico‐chemical and spectroscopic techniques. The study indicated that both the ligand and complex were capable of inhibiting Ehrlich Ascites Carcinoma (EAC) cells growth by 28.21% and 44.52%, respectively, when administered 0.3 mg/kg/day body weight intraperitoneally for five consecutive days in Swiss Webstar mice. Determination the LD50 of the complex (55 mg/kg) allowed adjusting the dose as 2.75 mg/kg and upon administration, inhibition increased to 69.36%. The ligand and complex have shown an inhibitory effect in the range of 4.86%–67.3% and 6.1%‐ 89.37%, respectively, against EAC cells (concentration range of 31.25–500 μg/ml) in RPMI‐1640 medium as determined by MTT colorimetric assay. Apoptotic cell morphological alteration was determined through optical and fluorescence microscopy. Up regulation of P53, Bax, Cas‐8, Cas‐3 and Fas and down regulation of NF‐kB and Bcl‐2 gene expression were observed in the cells treated with the nickel(ll) complex for five consecutive days. In conclusion, the newly synthesized nickel(ll) complex has shown anti‐proliferative activity and can further be optimized to be used as a lead molecule for anticancer drug.

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Section: Discussionmentioning

confidence: 99%

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Zahan

Rahi

Sheikh

et al. 2018

Applied Organom Chemis

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“…In this regard, ruthenium (III) is highly recommended, owing to its pharmacological reduction to Ru(II) and/or oxidation to Ru(IV) under physiologically related conditions . Importantly, the energy barrier for inter‐conversion between these oxidation states is relatively small, allowing for facile change in the oxidation state inside the cell …”

Section: Introductionmentioning

confidence: 99%

Novel Cr (III), Fe (III) and Ru (III) Vanillin Based Metallo‐Pharmaceuticals for Cancer and Inflammation Treatment: Experimental and Theoretical Studies

Abdel‐Rahman

El‐Khatib

Abdel‐Fatah

et al. 2019

Applied Organom Chemis

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In this study, three novel complexes comprising trivalent Cr (III), Fe (III) and Ru (III) with imine ligand derived from 2-amino-3-hydroxypyridine and ovanillin (H 2 L) have been synthesized and characterized via wide range of spectroscopic and analytical tools such as 1 H NMR and 13 C NMR, infrared (IR) and UV-Vis spectrophotometry, conductivity and magnetic measurements. The obtained results along with DFT data confirmed a 1:1 (metal: ligand) stoichiometry with non-planner geometries for the three complexes. The binding action and the docking study of the prepared metal-complexes to calf thymus DNA was also studied by absorption spectra and viscosity technique, which revealed that the three complexes interact strongly with DNA through intercalative binding mode. Significantly, these metal-imine complexes showed strong and efficient anti-inflammatory and antimicrobial activities against various gram-positive (Microccus luteus), gram-negative (Escherichia coli and Serratia marcescence) bacteria, and three strains of fungus. Moreover, all complexes exhibited more potent cytotoxicity effect on the outgrowth of different types of carcinoma cells, including human colon (HCT-116 cell line), breast (MCF-7 cell line), and hepatic cellular (HepG-2), than the clinically-proven Vinblastine standard.

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“…including N−O, 12,13 O-O, 14 P-P 15 and Se-Se chelates, [16][17][18][19][20] N,N,N-tridentate chelates [21][22][23][24][25][26] or bridged di-or tri-nuclear alkoxo/hydroxo are also known. [27][28][29] Additionally, but rarer, phototoxic Re complexes capable of either generating reactive oxygen species (ROS) or liberating CO have also been identified.…”

Section: However Examples Of Antiproliferative Fac-[re(co)3] + Complmentioning

confidence: 99%

“…The anticancer activity of fac-[Re(CO)3] + compounds has been tested on several different cancer cell lines. The majority of the studies were focused on antiproliferative effects on cervical, 30-33, 47, 51, 57-61 ovarian, 62,63 breast, 12,20,25,[64][65][66] and epithelial adenocarcinoma 24,49,67,68 cell lines showing IC50 values as low as e.g. 0.1 (HeLa), 30 1 (MCF-7), 15 0.75 (A549), 67 4 (NB69 and H4 cells) μM.…”

Section: In Vitro Anticancer Activity Evaluationmentioning

confidence: 99%

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Highly Potent Rhenium(I) Tricarbonyl Complexes with Dual Anticancer and Anti-Angiogenic Activity Against Colorectal Carcinoma

Delasoie¹,

Pavić²,

Voutier³

et al. 2020

Preprint

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Synthesized and characterized a series of rhenium(I) trycarbonyl-based complexes with increased lipophilicity. Two of these novel compounds were discovered to possess remarkable anticancer, anti-angiogenic and antimetastatic activity <i>in vivo</i> (zebrafish-human CRC xenograft model), being effective at very low doses (1-3 µM). At doses as high as 250 µM the complexes did not provoke toxicity issues encountered in clinical anticancer drugs (cardio-, hepato-, and myelotoxicity). The two compounds exceed the antiproliferative and anti-angiogenic potency of clinical drugs cisplatin and sunitinib-malate, and display a large therapeutic window.

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Antiproliferative effects of palladium(II) complexes of 5-nitrosopyrimidines and interactions with the proteolytic regulatory enzymes of the renin–angiotensin system in tumoral brain cells

Cited by 24 publications

References 44 publications

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Design, synthesis and X‐ray structural studies of novel [acetonitrile‐benzyl‐3‐N‐(2, 4 dihydroxyphenylmethylene) hydrazinecarbodithioato‐κ3‐N′, S, O] nickel(ll) complex that potently inhibit cell proliferation through regulation of apoptosis related genes

Novel Cr (III), Fe (III) and Ru (III) Vanillin Based Metallo‐Pharmaceuticals for Cancer and Inflammation Treatment: Experimental and Theoretical Studies

Highly Potent Rhenium(I) Tricarbonyl Complexes with Dual Anticancer and Anti-Angiogenic Activity Against Colorectal Carcinoma

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