Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Hu, Xu; Li, Dahong; Chang, Chun Ming; Xu, Lina; Wang, Xianhua; Jia, Ying; Hua, Hui‐Ming; Xu, Fanxing

doi:10.3390/ijms19113403

Cited by 56 publications

(35 citation statements)

References 161 publications

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“…T.G. Hartley., is a multitargeted anticancer agent [230]. In hepatocellular carcinoma cells (HepG2), evodiamine effectively hindered constitutive and IL-6-induced activation of STAT3 (Tyr705) phosphorylation.…”

Section: Evodiaminementioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

130

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Cancer is a prevalent cause of mortality around the world. Aberrated activation of Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway promotes tumorigenesis. Natural agents, including phytochemicals, exhibit potent anticancer activities via various mechanisms. However, the therapeutic potency of phytoconstituents as inhibitors of JAK/STAT signaling against cancer has only come into focus in recent days. The current review highlights phytochemicals that can suppress the JAK/STAT pathway in order to impede cancer cell growth. Various databases, such as PubMed, ScienceDirect, Web of Science, SpringerLink, Scopus, and Google Scholar, were searched using relevant keywords. Once the authors were in agreement regarding the suitability of a study, a full-length form of the relevant article was obtained, and the information was gathered and cited. All the complete articles that were incorporated after the literature collection rejection criteria were applied were perused in-depth and material was extracted based on the importance, relevance, and advancement of the apprehending of the JAK/STAT pathway and their relation to phytochemicals. Based on the critical and comprehensive analysis of literature presented in this review, phytochemicals from diverse plant origins exert therapeutic and cancer preventive effects, at least in part, through regulation of the JAK/STAT pathway. Nevertheless, more preclinical and clinical research is necessary to completely comprehend the capability of modulating JAK/STAT signaling to achieve efficient cancer control and treatment.

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Section: Evodiaminementioning

confidence: 99%

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Bose¹,

Banerjee²,

Mondal³

et al. 2020

Cells

130

View full text Add to dashboard Cite

show abstract

“…Evodiamine, found in the extract of Wuzhuyu, can inhibit the proliferation of cancer cells through various methods, such as blocking the cell cycle and inhibiting the proliferation of A549 cells. It can induce protective autophagy inf Lewis lung carcinoma cells and has good anticancer activity against many kinds of cancer cells [ 90 ]. Evodiamine can also effectively inhibit excessive gastrointestinal motility, providing a basis for the treatment of adverse reactions of diarrhea [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining

Dan

Liu

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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In this study, the role of traditional Chinese medicine (TCM) in relieving epidermal growth factor receptor-tyrosine kinase inhibitor- (EGFR-TKI-) associated diarrhea was discussed by network pharmacology and data mining. Prediction of drug targets by introducing the EGFR-TKI molecular structures into the SwissTargetPrediction platform and diarrhea-related targets in the DrugBank, GeneCards, DisGeNET, and OMIM databases were obtained. Compounds in the drug-disease target intersection were screened by absorption, distribution, metabolism, and excretion parameters and Lipinski’s rule in Traditional Chinese Medicine Systems Pharmacology. TCM-containing compounds were selected, and information on the property, taste, and meridian tropism of these TCMs was summarized and analyzed. A target-compound-TCM network diagram was constructed, and core targets, compounds, and TCMs were selected. The core targets and components were docked by AutoDock Vina (Version 1.1.2) to explore the target combinations of related compounds and evaluate the docking activity of related targets and compounds. Twenty-three potential therapeutic TCM targets for the treatment of EGFR-TKI-related diarrhea were obtained. There were 339 compounds acting on potential therapeutic targets, involving a total of 402 TCMs. The results of molecular docking showed good binding between the core targets and compounds, and the binding between the core targets and compounds was similar to that of the core target and the recommended drug loperamide. TCMs have multitarget characteristics and are present in a variety of compounds used for relieving EGFR-TKI-associated diarrhea. Antitumor activity and the efficacy of alleviating diarrhea are the pharmacological basis of combining TCMs with EGFR-TKI in the treatment of non-small-cell lung cancer. The core targets, compounds, and TCMs can provide data to support experimental and clinical studies on the relief of EGFR-TKI-associated diarrhea in the future.

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“…Rutaecarpine (Rut), an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa , is used to treat hypertension, dysentery, abdominal pain, headache, postpartum hemorrhage, and amenorrhea as a traditional medicine in Asia [ 10 ]. The pharmaceutical potential of alkaloids, in terms of inducing apoptosis of human colorectal cells and inhibiting the growth of human cancer cell lines, is established [ 11 ]. The proposed molecular mechanism is transactivation via the inhibition of the NF-κB and AP-1 signaling pathways.…”

Section: Introductionmentioning

confidence: 99%

Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes

et al. 2021

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Rutaecarpine, an indolopyridoquinazolinone alkaloid isolated from the unripe fruit of Evodia rutaecarpa, is used to treat hypertension, postpartum hemorrhage, dysentery, and amenorrhea as a traditional medicine in Asia. We investigated the effect of rutaecarpine on acetaminophen-induced hepatotoxicity in mice. Rutaecarpine was administered orally daily for seven consecutive days, followed by intraperitoneal injection of acetaminophen in mice on day seven to induce hepatotoxicity. Rutaecarpine pretreatment significantly decreased acetaminophen-induced serum alanine aminotransferase (ALT)/aspartate aminotransferase (AST) activities and hepatic malondialdehyde content and prevented acetaminophen-induced hepatic glutathione depletion. Furthermore, CYP2E1 expression was decreased by rutaecarpine pretreatment in a dose-dependent manner. Rutaecarpine pretreatment inhibited acetaminophen-induced expression of inflammatory cytokines by inhibiting NF-κB activation by JNK1/2. Also, rutaecarpine pretreatment promoted Nrf2-mediated activation of the antioxidant enzymes GCLC, HO-1, and NQO1. This indicates that the protective effect of rutaecarpine during acetaminophen-induced acute liver injury is mediated by the activation of antioxidant enzymes. Therefore, rutaecarpine has a protective effect of APAP-induced liver damage.

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Antiproliferative Effects of Alkaloid Evodiamine and Its Derivatives

Cited by 56 publications

References 161 publications

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy

The Use of Traditional Chinese Medicine in Relieving EGFR-TKI-Associated Diarrhea Based on Network Pharmacology and Data Mining

Rutaecarpine Protects against Acetaminophen-Induced Acute Liver Injury in Mice by Activating Antioxidant Enzymes

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