Antiproliferative Compounds from <i>Cleistanthus boivinianus</i> from the Madagascar Dry Forest1

Liu, Yixi; Young, Kelly A.; Rakotondraibe, L. Harinantenaina; Brodie, Peggy J.; Wiley, Jessica D.; Cassera, María B.; Callmander, Martin W.; Rakotondrajaona, Roland; Rakotobe, Etienne; Rasamison, Vincent E.; Tendyke, Karen; Shen, Yongchun; Kingston, David G. I.

doi:10.1021/np501020m

Cited by 24 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The coupling constant of 3.0 Hz between H-7 and H-8 suggested the cis-geometry of C-7 and C-8 . It was further confirmed by the NOESY interaction of H-7 and H-8 [16].…”

Section: Structure Elucidation Of Compounds 1 Andmentioning

confidence: 56%

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

et al. 2019

View full text Add to dashboard Cite

Two new aryltetralin lactone lignans, petasitesins A and B were isolated from the hot water extract of the leaves of butterbur (Petasites japonicus) along with six known compounds. The chemical structures of lignans 1 and 2 were elucidated on the basis of 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, electronic circular dichroism (ECD) and vibrational circular dichroism (VCD) spectra. Petasitesin A and cimicifugic acid D showed significant inhibitory effects on the production of both prostaglandin E2 (PGE2) and NO in RAW264.7 macrophages. The expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were inhibited by compound 1 in RAW264.7 cells. Furthermore, compounds 1 and 3 exhibited strong affinities with both iNOS and COX-2 enzymes in molecular docking studies.

show abstract

“…The coupling constant of 3.0 Hz between H-7 and H-8 suggested the cis-geometry of C-7 and C-8 . It was further confirmed by the NOESY interaction of H-7 and H-8 [16].…”

Section: Structure Elucidation Of Compounds 1 Andmentioning

confidence: 56%

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

et al. 2019

View full text Add to dashboard Cite

show abstract

“…As described before in several studies, the phenolic components (flavonoids, flavonoids, phenolic acid, tannins, etc.) revealed a wide range of biological properties such as antibacterial, antiviral, anticancer, anti-proliferative and anti-inflammatory [41][42][43][44][45]. These compounds or secondary metabolites particularly possess also anti-protozoan activities, especially against Plasmodium, Leishmania and Trypanosoma spp.…”

Section: Discussionmentioning

confidence: 99%

“…The results of DPPH, ABTS +• and FRAP tests of the optimum and the standard compounds (quercetin, oleuropein) were revealed by the antioxidant capacities. However, the difference of quercetin, oleuropein and the optimum of OP extract values could be attributed to a polar character which can contribute to the potentialisation of power to reduce the free radicals [44,65]. According to Miguel [66], some flavonoids having multiple hydroxyl (OH) groups act as pro-oxidants.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

et al. 2019

View full text Add to dashboard Cite

Aim The objective of the present study was to investigate in vitro anticoccidial effect of olive pulp (Olea europaea L var. Chemlal) extract on the destruction of Eimeria spp. oocysts isolated from infected chickens naturally. Materials and methods The olive pulp (OP) powder was stirred manually in aqueous ethanol in preparation for extraction using the microwave-assisted extraction system. The identification of the phenolic compounds was obtained by ultra-highperformance liquid chromatography-mass spectrometry with electrospray ionisation (HPLC-ESI-MS). The treatment of Eimeria oocyst with OP extract and standard compounds (quercetin and oleuropein) leads to their lysis as shown by the release of substances absorbing at 273 nm. Results Our results showed that the maximum number of reduced oocysts was recorded after 8 h of incubation of optimum OP extract, quercetin and oleuropein for different periods of time. Also, the number of Eimeria oocysts decreased considerably with increase concentrations after adding the optimum of OP extract in concentration ranging from 0.023 to 0.371 mg/ ml. Positive correlation between the optimum OP extract concentrations and the number of Eimeria oocysts reduced was R 2 = 0.959. From this in vitro experiment, it can be concluded that the OP extract possesses an anti-Eimeria spp activity. Conclusion To our knowledge, this is the first time that quercetin and oleuropein were tested to evaluate their anticoccidial activity. The findings of this study showed that phenolic compound of OP extract tested separately possesses anti-Eimeria spp. effect. Further studies should be carried out to test its in vivo efficacy of the OP bioactive compounds in broiler chickens.

show abstract

“…12) 3.2. Diterpenoids Three novel diterpenoids, gravilin (38), dihomoditerpenoid ketone (39), and isodecaryiol (40), along with three known compounds, (+)-(S)-geranyllinalool, (−)-(R)-nephthenol, and 11,12-epoxysarcophytol A, were isolated from the methanol extract of the Madagascan soft coral Sinularia gravis. Compound 38 is a spatane-type diterpenoid, while 39 and 40 are dihomo-and scalarane-type diterpenoids, respectively.…”

Section: Alkaloidsmentioning

confidence: 99%

“…37) Two new lignans, 3α-O-(β-D-glucopyranosyl) desoxypodophyllotoxin (117) and 4-O-(β-D-glucopyranosyl) dehydropodophyllotoxin (118), were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin, (±)-β-apopicropodophyllin, (−)-desoxypodophyllotoxin, (−)-yatein, and β-peltatin-5-O-β-D-glucopyranoside.Both of the novel compounds exhibited strong antiproliferative activity against the A2780 human ovarian cancer cell line, with IC 50 values of 0.033 and 2.1 µM, respectively. In addition, compound 117 also displayed potent antiproliferative activity against the HCT-116 human colon carcinoma cell line, with an IC 50 value of 0.021 µM 38).…”

mentioning

confidence: 99%

Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)

Dai

Liu

Rakotondraibe

2018

CHEMICAL & PHARMACEUTICAL BULLETIN

Self Cite

View full text Add to dashboard Cite

Madagascar's rain forests and tropical dry forests are home to numerous endemic plant species and the island is considered a biodiversity hotspot. About 80% of the Madagascan (Malagasy) population relies on traditional medicines that have been proven to contain a variety of biologically active compounds. In the search for bioactive compounds from Madagascan biodiversity, we accessed and collected most of the literature dealing with the isolation, structure elucidation, and biological activities of organic small molecules originating from Madagascan plants and marine organisms. Since we published the first review of this work in 2009 (Curr. Med. Chem., 17, 2010, Hou and Harinantenaina), the present paper covers the isolation, structures, and bioactivity of 182 new secondary metabolites isolated from Malagasy higher plants and marine organisms in the last seven years (2009-2017).

show abstract

Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1

Cited by 24 publications

References 31 publications

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

Chemical Constituents of the Leaves of Butterbur (Petasites japonicus) and Their Anti-Inflammatory Effects

In Vitro Anticoccidial Activity of Olive Pulp (Olea europaea L. var. Chemlal) Extract Against Eimeria Oocysts in Broiler Chickens

Novel Bioactive Natural Products Isolated from Madagascar Plants and Marine Organisms (2009–2017)

Contact Info

Product

Resources

About