Antiproliferative, Anti-Aromatase, Anti-17β-HSD and Antioxidant Activities of Lignans Isolated from<i>Myristica argentea</i>

Filleur, F.; Bail, J.C Le; Duroux, Jean‐Luc; Simon, András; Chulia, Albert J.

doi:10.1055/s-2001-18349

Cited by 35 publications

(26 citation statements)

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“…Macelignan, a natural compound belonging to a group of lignans isolated from Myristica fragrans Houtt., has been reported to have various biological activities, including antioxidant, antiinflammatory, anticariogenic, and antihepatotoxic properties [25][26][27][28][29][30]. Macelignan has also been shown to function as an antidiabetic and endoplasmic reticulum stress-relief agent [31].…”

mentioning

confidence: 98%

Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

Anggakusuma

Yanti

Hwang

2010

Journal of Dermatological Science

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mentioning

confidence: 98%

Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

Anggakusuma

Yanti

Hwang

2010

Journal of Dermatological Science

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“…Enterolactone (167) was moderately active in microsomes and strongly active using Arom+HEK 293 cells [153]. Nordihydroguaiaretic acid (172) was weakly active in micromal testing [145], although this compound was also found to be inactive in microsomes by another group [154]. Of the other lignans tested, 4,4'-dihydroxyenterolactone (164) From the literature, nineteen natural product peptides were tested for aromatase inhibition (Table 13, Fig.…”

Section: Natural Product Compounds Tested For Aromatase Inhibitionmentioning

confidence: 99%

Natural Products as Aromatase Inhibitors

Balunas¹,

Su²,

Brueggemeier³

et al. 2008

ACAMC

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With the clinical success of several synthetic aromatase inhibitors (AIs) in the treatment of postmenopausal estrogen receptor-positive breast cancer, researchers have also been investigating also the potential of natural products as AIs. Natural products from terrestrial and marine organisms provide a chemically diverse array of compounds not always available through current synthetic chemistry techniques. Natural products that have been used traditionally for nutritional or medicinal purposes (e.g., botanical dietary supplements) may also afford AIs with reduced side effects. A thorough review of the literature regarding natural product extracts and secondary metabolites of plant, microbial, and marine origin that have been shown to exhibit aromatase inhibitory activity is presented herein. Keywordsaromatase inhibitors; natural products; breast cancer; botanical dietary supplements BREAST CANCERWorldwide breast cancer estimates included over one million incident cases and almost 400,000 deaths in the year 2000 [1,2]. In the United States, over 178,000 women were expected to be diagnosed with breast cancer in 2007 with over 40,000 deaths occurring from the disease [3]. In developed countries, mortality from breast cancer has recently begun to decline, primarily due to earlier detection and improved treatments [4,5]. Breast cancer is thought to be a result of inherited genetic predisposition (e.g., mutations in genes such as BRCA-1, p53, PTEN/MMAC1, and/or ATM) and/or environmental factors (e.g., radiation exposure, dietary factors, alcohol consumption, hormonal exposure) [2,6,7]. Numerous genetic mutations are necessary for breast cancer development and progression including the acquisition of the capabilities for self-sufficiency in growth signals, insensitivity to anti-growth signals, evasion of apoptosis, limitless replicative potential, sustained angiogenesis, and tissue invasion and metastasis, known collectively as the "hallmarks of cancer" [8].Numerous molecular targets have been identified as playing a significant role in breast cancer development and progression. Estrogens and the estrogen receptors (ERs) are widely NIH Public Access Author ManuscriptAnticancer Agents Med Chem. Author manuscript; available in PMC 2011 April 12.Published in final edited form as:Anticancer Agents Med Chem. 2008 August ; 8(6): 646-682. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript recognized to play an important role in the development and progression of breast cancer, making estrogens and the ERs widely studied molecular targets [9][10][11][12]. Two of the endogenous estrogens found in humans include estradiol and estrone. In pre-menopausal women, estrogens are produced primarily through conversion of androgens in the ovaries while estrogen production in postmenopausal women occurs in only peripheral tissues [13,14]. Estrogens have various effects throughout the body, including positive effects on the brain, bone, heart, liver, and vagina, with negative effects such as increased risk...

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“…Fractions 20 (1.3 g) and 26 (1.0 g) were subjected to reverse-phase column chromatography (4 × 50 cm, LiChroprep RP-18) using MeOH-H 2 O (gradient elution, from 40%-100% MeOH) to give 11 (70 mg) and 12 (40 mg), respectively. erythro-Austrobailignan-6 (1) The compound was obtained as a yellow oil; [α] D 25 +4.8°( c 1, CHCl 3 ); 1 H-and 13 C-NMR data were consistent with the literature values (Nakatani et al, 1988;Filleur et al, 2001)…”

Section: Extraction and Isolationmentioning

confidence: 94%

Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

et al. 2009

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Thirteen lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC(50) values; 13, 12, 11, and 10 microM, respectively) and HepG2 cell lines (IC(50) values; 16, 11, 12, and 11 microM, respectively).

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Antiproliferative, Anti-Aromatase, Anti-17β-HSD and Antioxidant Activities of Lignans Isolated fromMyristica argentea

Cited by 35 publications

References 0 publications

Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induced matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells

Natural Products as Aromatase Inhibitors

Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

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