Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

Lee, Yeun-Kyung; Seo, Chang‐Seob; Lee, Chong-Soon; Lee, Kyong-Seon; Kang, Shin-Jung; Jahng, Yurngdong; Chang, Hyun Wook; Son, Jong‐Keun

doi:10.1007/s12272-009-2010-7

Cited by 31 publications

(17 citation statements)

References 29 publications

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“…The isolated lignans from S. chinensis and S. cernuus showed potential anti-inflammatory, anti-metastatic, neuroleptic, and cholesterol-lowering activities [15,16,[28][29][30][31][32][33]. Additionally, these compounds exhibited hepatoprotective, antifibrotic, antiseptic, antioxidative, anti-tumor DNA replication, and anti-HIV effects [2,4,[34][35][36]. Therefore, the Saururus species of plants may be useful in human diseases.…”

Section: Discussionmentioning

confidence: 99%

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Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

Suh

Kwak

et al. 2012

International Immunopharmacology

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Section: Discussionmentioning

confidence: 99%

“…Furthermore, we reported on the isolation and cytotoxic activity of lignans from the roots of S. chinensis including four new lignans saucerneol F (SF) (Fig. 1), saucerneol G, saucerneol H, and saucerneol I [2,4].…”

Section: Introductionmentioning

confidence: 99%

Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

Suh

Kwak

et al. 2012

International Immunopharmacology

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“…MB, a neolignan isolated from the roots of S. chinensis, has been demonstrated to exhibit a range of activities, including anti-inflammatory (10,(19)(20)(21), antiseptic (22) and antitumor activities (11,23). Furthermore, MB was shown to inhibit PMA-induced ICAM-1 expression in HL-60 cells (15) and to prevent monocyte adhesion to HUVECs through the inhibition of ICAM-1, VCAM-1 and E-selectin expression stimulated by TNF-α (24).…”

Section: Discussionmentioning

confidence: 99%

“…It has a long history of use in China as a folk medicine to remedy various edema, gonorrhea, jaundice and inflammatory diseases (9)(10)(11). Previous phytochemical and pharmacological studies on this plant have revealed several types of secondary metabolites, such as lignans, neolignans, aristolactams and flavonoids, as the biologically active compounds (12,13).…”

Section: Introductionmentioning

confidence: 99%

The dineolignan from Saururus chinensis, manassantin B, inhibits tumor-induced angiogenesis via downregulation of matrix metalloproteinases 9 in human endothelial cells

Liu

et al. 2014

Oncology Reports

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Abstract. Manassantin B (MB) is a neolignan isolated fromSaururus chinensis that exhibits a range of activities, including anti-inflammatory, antiseptic and antitumor activity. MB was recently found to affect cell adhesion and expression of several adhesion molecules. Based on the important roles of these adhesion molecules in angiogenesis, we evaluated a possible role for MB in tumor-induced angiogenesis in endothelial cells (ECs). In the present study, we found that MB blocked tumor-induced tube formation of ECs and significantly inhibited the invasion of ECs through the reconstituted basement membrane. MB suppressed the activity of matrix metalloproteinases (MMPs) and downregulated the expression of matrix metalloproteinases 9. Western blotting showed reduction of RUNX2 activation by MB. RUNX2 transcription factor assay and chromatin immunoprecipitation assay showed that the interaction between RUNX2 and target sequences in the matrix metalloproteinases 9 promoters was inhibited by MB. Our findings suggested that the inhibitory effects of MB on tumor-induced angiogenesis were caused by matrix metalloproteinases 9 inhibition, which was associated with the downregulation of RUNX2 transcriptional activity. IntroductionAngiogenesis, the development of novel blood vessels, is a critical event in many important disease states including ischemic cardiovascular disease, wound healing, inflammation, psoriasis, primary tumor growth and formation of metastases. It is a highly complex process involving endothelial cell (EC) activation, disruption of vascular basement membranes, and migration and proliferation of ECs (1). This process is orchestrated by a large number of cytokines and associated receptors and proteinases, such as vascular endothelial growth factor (VEGF), fibroblast growth factor, interleukin 8 and matrix metalloproteinases (MMPs) (2). Tumor-induced angiogenesis is a process of irregular blood vessel formation, which results in structurally and functionally abnormal blood vessels. This abnormality impairs effective delivery of therapeutic agents to all regions of tumors, it creates abnormal properties of cancer cells, such as survival, resistance of radiation and chemotherapy, and selects for more malignant cells (3). Several decades ago, Dr Folkman proposed anti-angiogenic therapy as an effective method for treatment of cancer (4,5). Nowadays, a number of inhibitors targeting the tumor vasculature have been identified to improve the sensitivity of cancer cells to cytotoxic chemotherapy and other therapeutics (6-8).Saururus chinensis (S. chinensis) is a perennial herbaceous plant that grows wild in moist and shady places throughout East Asia (9). It has a long history of use in China as a folk medicine to remedy various edema, gonorrhea, jaundice and inflammatory diseases (9-11). Previous phytochemical and pharmacological studies on this plant have revealed several types of secondary metabolites, such as lignans, neolignans, aristolactams and flavonoids, as the biologically active compounds (12,13). Numer...

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“…7) Manassantin B (Man B) is a neolignan isolated from the roots of Saururus chinensis (S. chinensis) and has been reported to exert various biological activities, including antiinflammatory, 8,9) anti-septic, 10) anti-human immunodeficiency virus (HIV), 11) and anti-tumor activities. 12) In addition, Man B has been shown to inhibit hyperpigmentation and the expressions of adhesion molecules. 13,14) However, the effects of Man B on PGD 2 generation in mast cells have not been previously reported.…”

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Manassantin B Isolated from <i>Saururus chinensis</i> Inhibits Cyclooxygenase-2-Dependent Prostaglandin D<sub>2</sub> Generation by Blocking Fyn-Mediated Nuclear Factor-kappaB and Mitogen Activated Protein Kinase Pathways in Bone Marrow Derived-Mast Cells

Hwang

Son

et al. 2013

Biological & Pharmaceutical Bulletin

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Mast cells are involved in various allergy and inflammatory responses due to the aggregation of high-affinity immunoglobulin E (IgE) receptor (FcεRI) on their surfaces. 1)The aggregation of FcεRI results in the release of preformed mediators (e.g., histamine and proteases), newly synthesized lipid mediators (e.g., prostaglandin D 2 (PGD 2 ) and leukotriene C 4 (LTC 4 )) and various cytokines.2,3) IgE/Ag stimulation of mast cells activates a variety of Src family kinases such as Lyn and Fyn. 4,5) Subsequently, immunoreceptor tyrosine-based activation motifs (ITAM) of the β and γ subunits of FcεRI become phosphorylated by the Lyn and associated with tyrosine kinase Syk. Syk then phosphorylates linker for activation of T cells (LAT), phospholipase Cγ (PLCγ), and SH2 domain-containing leukocyte protein of 76 kDa (SLP-76). These reactions then stimulate mitogen-activated protein kinases (MAPKs) pathways as well as transcription factors such as nuclear factor-kappaB (NF-κB) and AP-1

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Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

Cited by 31 publications

References 29 publications

Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-κB and AP-1 inactivation in LPS-induced RAW264.7 cells

The dineolignan from Saururus chinensis, manassantin B, inhibits tumor-induced angiogenesis via downregulation of matrix metalloproteinases 9 in human endothelial cells

Manassantin B Isolated from <i>Saururus chinensis</i> Inhibits Cyclooxygenase-2-Dependent Prostaglandin D<sub>2</sub> Generation by Blocking Fyn-Mediated Nuclear Factor-kappaB and Mitogen Activated Protein Kinase Pathways in Bone Marrow Derived-Mast Cells

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