Antiproliferative and cytotoxic activity of infusions from four Staphylea L. species

Laciková, Ľ; Mrižová, M.; Maśterová, I; Grančai, D; Ficková, M

doi:10.1055/s-0028-1084216

Planta Med

2008

DOI: 10.1055/s-0028-1084216

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Antiproliferative and cytotoxic activity of infusions from four Staphylea L. species

Ľ Laciková¹,

M. Mrižová²,

I Maśterová³

et al.

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2009

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“…Significant antibacterial and cytotoxic activity of ethanolic extracts of S. holocarpa and S. pinnata have been reported [15,16]. Also, significant antioxidant and immunomodulating activity have been found in various Staphylea extracts [17,18]. The objective of our study was to investigate the anti-inflammatory activity of light petroleum extracts of four Staphylea species, to compare them and to determine their fatty acid content in order to elucidate the potential compounds responsible for these effects.…”

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Antiinflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species

Laciková

Pferschy‐Wenzig

Maśterová

et al. 2009

Natural Product Communications

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Staphylea preparations are used in TCM and have been used by native Americans for a number of indications, such as rheumatism. Based on this knowledge, the anti-inflammatory activity of light petroleum extracts of leaves of Staphylea colchica Stev., S. elegans Zab., S. holocarpa Hemsl. and S. pinnata L. has been determined using in vitro assays for inhibition of cyclooxygenase (COX-1 and COX-2) and leukotriene B 4 (LTB 4) formation by lipoxygenase (5-LOX). All extracts inhibited COX-1 and COX-2, with S. holocarpa and S. elegans performing best. Inhibition of LTB 4 formation was less pronounced. As unsaturated fatty acids are known to inhibit arachidonic acid metabolism in vitro, the fatty acid content was determined of the active extracts and set in correlation with their activity. Unsaturated fatty acids were found to contribute to the observed COX-2 and LTB 4 formation inhibitory activity to a different extent.

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confidence: 99%

Antiinflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species

Laciková

Pferschy‐Wenzig

Maśterová

et al. 2009

Natural Product Communications

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Antiproliferative and cytotoxic activity of infusions from four Staphylea L. species

Cited by 1 publication

References 0 publications

Antiinflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species

Antiinflammatory Potential and Fatty Acid Content of Lipophilic Leaf Extracts of Four Staphylea L. Species

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