Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells

Pelinson, Luana Paula; Assmann, Charles Elias; Palma, Taís Vidal; Cruz, Ivana Beatrice Mânica da; Pillat, Micheli Mainardi; Mânica, Aline; Stefanello, Naiara; Weis, Grazielle Castagna Cezimbra; Alves, Audrei de Oliveira; Andrade, Cínthia Melazzo de; Ulrich, Henning; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Bagatini, Margarete Dulce

doi:10.1007/s11033-019-04658-1

Cited by 77 publications

(49 citation statements)

References 38 publications

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“…Interestingly, CA exhibited an important role in the prevention of tumor progression via decrease in cell viability and induction of apoptosis. Moreover, CA treatment led to the cell cycle modulation, inhibition of colony formation, and changes in the expression of caspases [58]. Importantly, CA attenuated cancer stem cells-like properties via inhibition of TGFβ-SMAD2 signaling pathway mediated by microRNA-148a in vitro as well as in vivo mouse models [59].…”

Section: Caffeic Acidmentioning

confidence: 97%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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Globally, cancer is the second leading cause of death. Different conventional approaches to treat cancer include chemotherapy or radiotherapy. However, these are usually associated with various deleterious effects and numerous disadvantages in clinical practice. In addition, there are increasing concerns about drug resistance. In the continuous search for safer and more effective treatments, plant-derived natural compounds are of major interest. Plant phenolics are secondary metabolites that have gained importance as potential anti-cancer compounds. Phenolics display a great prospective as cytotoxic anti-cancer agents promoting apoptosis, reducing proliferation, and targeting various aspects of cancer (angiogenesis, growth and differentiation, and metastasis). Phenolic acids are a subclass of plant phenolics, furtherly divided into benzoic and cinnamic acids, that are associated with potent anticancer abilities in various in vitro and in vivo studies. Moreover, the therapeutic activities of phenolic acids are reinforced by their role as epigenetic regulators as well as supporters of adverse events or resistance associated with conventional anticancer therapy. Encapsulation of phyto-substances into nanocarrier systems is a challenging aspect concerning the efficiency of natural substances used in cancer treatment. A summary of phenolic acids and their effectiveness as well as phenolic-associated advances in cancer treatment will be discussed in this review.

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Section: Caffeic Acidmentioning

confidence: 97%

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

et al. 2020

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“…Chlorogenic acid induces apoptosis and selectively inhibits proliferation of A498 human renal cancer cells but not of HEK293 human embryonic kidney cells (Wang et al, 2019). Caffeic acid inhibits proliferation of hepatocellular carcinoma cells and SK-Mel-28 human melanoma cancer cells by inducing apoptosis (Brautigan et al, 2018), alters gene expression in SK-Mel-28 cells (Pelinson et al, 2019), and attenuates the properties of cancer stem cell-like cells by increasing DNA methylating and inducing the expression of miR-148a (Li et al, 2015). Both caffeic acid and chlorogenic acid suppress DNA methylation in MCF-7 and MDA-MB-231 human breast cancer cells (Lee and Zhu 2006).…”

Section: Introductionmentioning

confidence: 99%

Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines

et al. 2020

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Dietary phenolic compounds such as caffeic and chlorogenic acid exert an antiproliferative effect and modulate the gene-specific DNA methylation status in human breast tumor cells, but it remains unclear whether they interfere with global DNA methylation in human leukemia cells. We examined whether caffeic and chlorogenic acid (1-250 mM) exert antitumor action in human promyelocytic leukemia cells (HL-60) and human acute T-cell leukemia cells (Jurkat). Caffeic and chlorogenic acid did not reduce cell viability in the two cell lines, as assessed using the neutral red uptake and MTT assays. These phenolic acids (1-100 mM) neither induced DNA damage (comet assay) nor increased the micronuclei frequency (micronucleus assay) in HL-60 and Jurkat cells, indicating that they were not genotoxic or mutagenic. Analysis of global DNA methylation levels using a 5-mC DNA ELISA kit revealed that chlorogenic acid at a non-cytotoxic concentration (100 mM) induced global DNA hypomethylation in Jurkat cells, but not in HL-60 cells, suggesting that it exerts a cell-specific effect. Caffeic acid did not change global DNA methylation. As other phenolic compounds, chlorogenic acid probably modulates DNA methylation by targeting DNA methyltransferases. The hypomethylating action of chlorogenic acid can be beneficial against hematological malignances whose pathogenic processes involve impairment of DNA methylation.

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“…The antioxidant properties are generally based on its structural features, namely the hydroxyl group which neutralizes the reactive oxygen species as it acts as an electron donor, the vinyl chain and the methoxyl group which increase molecule stability, and the carboxylic group which prevents lipid peroxidation [ 92 ]. Moreover, caffeic acid acts as a chemopreventive agent by modulating inflammatory signaling [ 93 ], suppressing the rapamycin cascade signaling, inducing apoptosis [ 94 ], and altering cell cycle and caspase gene expression [ 95 ].…”

Section: Natural Anti-cancer Agents For Skin Cancermentioning

confidence: 99%

Regenerative Wound Dressings for Skin Cancer

Pavel

Chircov

Rădulescu

et al. 2020

Cancers

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Skin cancer is considered the most prevalent cancer type globally, with a continuously increasing prevalence and mortality growth rate. Additionally, the high risk of recurrence makes skin cancer treatment among the most expensive of all cancers, with average costs estimated to double within 5 years. Although tumor excision is the most effective approach among the available strategies, surgical interventions could be disfiguring, requiring additional skin grafts for covering the defects. In this context, post-surgery management should involve the application of wound dressings for promoting skin regeneration and preventing tumor recurrence and microbial infections, which still represents a considerable clinical challenge. Therefore, this paper aims to provide an up-to-date overview regarding the current status of regenerative wound dressings for skin cancer therapy. Specifically, the recent discoveries in natural biocompounds as anti-cancer agents for skin cancer treatment and the most intensively studied biomaterials for bioactive wound dressing development will be described.

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Antiproliferative and apoptotic effects of caffeic acid on SK-Mel-28 human melanoma cancer cells

Cited by 77 publications

References 38 publications

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Therapeutic Potential of Plant Phenolic Acids in the Treatment of Cancer

Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines

Regenerative Wound Dressings for Skin Cancer

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