2020
DOI: 10.1590/1678-4685-gmb-2019-0347
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Caffeic acid and chlorogenic acid cytotoxicity, genotoxicity and impact on global DNA methylation in human leukemic cell lines

Abstract: Dietary phenolic compounds such as caffeic and chlorogenic acid exert an antiproliferative effect and modulate the gene-specific DNA methylation status in human breast tumor cells, but it remains unclear whether they interfere with global DNA methylation in human leukemia cells. We examined whether caffeic and chlorogenic acid (1-250 mM) exert antitumor action in human promyelocytic leukemia cells (HL-60) and human acute T-cell leukemia cells (Jurkat). Caffeic and chlorogenic acid did not reduce cell viability… Show more

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Cited by 28 publications
(14 citation statements)
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“…Besides, a recent study showed that chlorogenic acid, a main compound identified in the Seseli species in the current study, did not reduce viability of human promyelocytic leukemia cells (HL-60) and human acute T-cell leukemia cells (Jurkat). Furthermore, chlorogenic acid at a concentration of 100 µM induced global DNA hypomethylation, a cell-specific effect in Jurkat cells [71]. Another study showed that chlorogenic acid exhibited cytotoxic activity via hydrogen peroxide-mediated oxidation mechanism in human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines [72].…”
Section: Resultsmentioning
confidence: 99%
“…Besides, a recent study showed that chlorogenic acid, a main compound identified in the Seseli species in the current study, did not reduce viability of human promyelocytic leukemia cells (HL-60) and human acute T-cell leukemia cells (Jurkat). Furthermore, chlorogenic acid at a concentration of 100 µM induced global DNA hypomethylation, a cell-specific effect in Jurkat cells [71]. Another study showed that chlorogenic acid exhibited cytotoxic activity via hydrogen peroxide-mediated oxidation mechanism in human oral squamous cell carcinoma (HSC-2) and salivary gland tumor (HSG) cell lines [72].…”
Section: Resultsmentioning
confidence: 99%
“…These results could be attributed to the high quantity of polyphenols which are known to modulate pathways relevant to proliferation, migration or colony formation and in some particular cases cell death could be triggered [ 27 , 28 , 29 , 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was also described that it is able to interact with key molecules that can further modulate critical biological pathways involved in cell survival or proliferation [ 34 ]. It was also shown that chlorogenic acid can enhance the antitumor effect of conventional therapeutic agents like doxorubicin by protecting the non-cancer cells against doxorubicin toxicity [ 35 ] or induce hypomethylation of Jurkat cells, being benefic in the case of hematological malignancies [ 27 ].…”
Section: Discussionmentioning
confidence: 99%
“…327‐97‐9) at concentrations between 0.001 and 1.5 mmol/L was toxic to the normal fibroblast cell cultures and the melanoma cell cultures. The concentration range was selected on the basis of research on various cell lines (Hernandes et al., 2020; Hou et al., 2017; Sadeghi Ekbatan et al, 2018).…”
Section: Methodsmentioning
confidence: 99%