Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the Myrtaceae Family

Frauches, Nayara Simas; Montenegro, Júlia; Amaral, Thuane Oliveira do; Abreu, Joel Pimentel de; Laiber, Gabriela; Júnior, Jorge Luiz Medeiros; Borguini, Renata Galhardo; Santiago, Manuela Cristina Pessanha de Araújo; Pacheco, Sidney; Nakajima, Vânia Mayumi; Godóy, Ronoel Luiz de Oliveira; Teodoro, Anderson Junger

doi:10.3390/molecules26030564

Cited by 19 publications

(16 citation statements)

References 68 publications

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“…Similar effects were verified using coloured phenolics from pollen, but at a higher concentration (10 mg/mL) [ 175 ]. Concentrations higher than 500 µg/mL of anthocyanin-rich extracts from the Myrtaceae family also showed an ability to reduce the proliferation of human colon adenocarcinoma HT-29 cells, mainly by arresting the G2/M phase, hence causing cell apoptosis in comparison with the control group over 24 h of treatment [ 176 ]. It was also already verified that anthocyanin-rich extracts from pomegranate at 50 µg/mL can reduce by 10% the growth of human bladder cancer T24 cells growth after 48 h of exposure, in comparison with untreated cells [ 170 ].…”

Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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In recent years, the consumption of natural-based foods, including beans, fruits, legumes, nuts, oils, vegetables, spices, and whole grains, has been encouraged. This fact is essentially due to their content in bioactive phytochemicals, with the phenolic compounds standing out. Among them, anthocyanins have been a target of many studies due to the presence of catechol, pyrogallol, and methoxy groups in their chemical structure, which confer notable scavenging, anti-apoptotic, and anti-inflammatory activities, being already recommended as supplementation to mitigate or even attenuate certain disorders, such as diabetes, cancer, and cardiovascular and neurological pathologies. The most well-known anthocyanins are cyanidin 3-O-glucoside and cyanidin 3-O-rutinoside. They are widespread in nature, being present in considerable amounts in red fruits and red vegetables. Overall, the present review intends to discuss the most recent findings on the potential health benefits from the daily intake of anthocyanin-rich foods, as well as their possible pharmacological mechanisms of action. However, before that, some emphasis regarding their chemical structure, dietary sources, and bioavailability was done.

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Section: Putative Health Benefitsmentioning

confidence: 99%

Dietary Effects of Anthocyanins in Human Health: A Comprehensive Review

et al. 2021

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“…The biological implication of the gut-derived PC metabolites of JPP remains unknown as previous studies on JPP fermentation were limited to the description of PC transformation during simulated digestion [ 12 ]. Although the antiproliferative effect of JPP extract in HT29 monolayer cells has been recently reported [ 13 ], no studies were found regarding the antiproliferative effects in CRC 3D cell models or the effects of colonic fermented JPP (FJPP).…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Effect of Colonic Fermented Phenolic Compounds from Jaboticaba (Myrciaria trunciflora) Fruit Peel in a 3D Cell Model of Colorectal Cancer

et al. 2021

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Jaboticaba is a Brazilian native berry described as a rich source of phenolic compounds (PC) with health promoting effects. PC from jaboticaba peel powder (JPP) have low intestinal bio-accessibility and are catabolized by gut microbiota. However, the biological implication of PC-derived metabolites produced during JPP digestion remains unclear. This study aimed to evaluate the antiproliferative effects of colonic fermented JPP (FJPP) in a 3D model of colorectal cancer (CRC) composed by HT29 spheroids. JPP samples fermented with human feces during 0, 2, 8, 24 or 48 h were incubated (10,000 µg mL−1) with spheroids, and cell viability was assessed after 72 h. Chemometric analyses (cluster and principal component analyses) were used to identify the main compounds responsible for the bioactive effect. The antiproliferative effect of FJPP in the CRC 3D model was increased between 8 h and 24 h of incubation, and this effect was associated with HHDP-digalloylglucose isomer and dihydroxyphenyl-γ-valerolactone. At 48 h of fermentation, the antiproliferative effect of FJPP was negligible, indicating that the presence of urolithins did not improve the bioactivity of JPP. These findings provide relevant knowledge on the role of colonic microbiota fermentation to generate active phenolic metabolites from JPP with positive impact on CRC.

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“…Anthocyanins could have both chemopreventive and therapeutic effects against various types of cancer. In this Special Issue, four papers explored the anthocyanins’ anti-cancer effects [ 5 , 6 , 7 , 8 ]. Two of those papers report the results of in vitro studies carried out, by the same research group, to evaluate the anticancer effects of Vitis coignetiae Pulliat [ 5 , 6 ].…”

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confidence: 99%

“…This result highlights the need for further research to validate the anti-cancer effects of anthocyanins in highly metastatic cancer or far advanced cancers characterized by high TNF-α levels [ 7 ]. Simas Frauches et al [ 8 ] carried out a study which aimed to characterize and compare the constituents of jabuticaba ( Myrciaria jaboticaba ), Jamun berry ( Syzygium cumini ), and Malay apple ( Syzygium malaccense ) extracts and their effect on antioxidant activity in vitro and antiproliferative effects on human colon adenocarcinoma cells. The results, published in this Special Issue, show a decrease in cell viability of HT-29 cells after treatment with Myrtaceae fruits extracts.…”

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confidence: 99%